Psychotomimetic Effects of Drugs - A Common Pathway to Schizophrenia?

New England Journal of Medicine

Volumn 350, Issue 10, 2004, Pages 1047-1048

  Gerber, David J ^a   Tonegawa, Susumu ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; LYSERGIDE; PHENCYCLIDINE; PHOSPHOPROTEIN DARPP 32; PSYCHEDELIC AGENT;

ANIMAL EXPERIMENT; CORPUS STRIATUM; DISEASE ASSOCIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA; SHORT SURVEY;

AMPHETAMINE; ANIMALS; CENTRAL NERVOUS SYSTEM AGENTS; CORPUS STRIATUM; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; FRONTAL LOBE; LYSERGIC ACID DIETHYLAMIDE; MICE; MODELS, ANIMAL; NERVE TISSUE PROTEINS; PHENCYCLIDINE; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTORS, DOPAMINE; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

EID: 1442355044     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMcibr033201     Document Type: Short Survey

References (4)

1. Svenningsson P, Tazavara, ET, Carruthers R, et al. Diverse psychotomimetics act through a common signaling pathway. Science 2003;302:1412-5.
2. Ralph-Williams RJ, Lehmann-Masten V, Otero-Corchon V, Low MJ, Geyer MA. Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice. J Neurosci 2002;22:9604-11.
3. Miyakawa T, Leiter LM, Gerber DJ, et al. Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. Proc Natl Acad Sci U S A 2003;100:8987-92.
4. Gerber DJ, Hall D, Miyakawa T, et al. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Proc Natl Acad Sci U S A 2003;100:8993-8.