메뉴 건너뛰기




Volumn 18, Issue 1, 2004, Pages 63-67

Spotlight on Lamotrigine in Bipolar Disorder

Author keywords

Bipolar Depression; Bipolar Disorder; Bodyweight Gain; Lamotrigine; Valproate Semisodium

Indexed keywords

CARBAMAZEPINE; LAMOTRIGINE; LITHIUM; VALPROATE SEMISODIUM; ANTIDEPRESSANT AGENT; TRIAZINE DERIVATIVE;

EID: 1442354104     PISSN: 11727047     EISSN: 11791934     Source Type: Journal    
DOI: 10.2165/00023210-200418010-00007     Document Type: Article
Times cited : (45)

References (47)
  • 1
    • 0027179598 scopus 로고
    • Lamotrigine: a review of its pharmacological properties and clinical efficacy in epilepsy
    • COI: 1:STN:280:DyaK2c%2FgvVGltg%3D%3D, PID: 7691504
    • Goa KL, Ross SR, Chrisp P, et al. Lamotrigine: a review of its pharmacological properties and clinical efficacy in epilepsy. Drugs 1993; 46(1): 152–76
    • (1993) Drugs , vol.46 , Issue.1 , pp. 152-176
    • Goa, K.L.1    Ross, S.R.2    Chrisp, P.3
  • 2
    • 0036018480 scopus 로고    scopus 로고
    • Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?
    • COI: 1:CAS:528:DC%2BD38XkvFymtb8%3D, PID: 12103447
    • Li X, Ketter TA, Frye MA. Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders? J Affect Disord 2002 May; 69(1–3): 1–14
    • (2002) J Affect Disord , vol.69 , Issue.1-3 , pp. 1-14
    • Li, X.1    Ketter, T.A.2    Frye, M.A.3
  • 3
    • 0029125093 scopus 로고
    • Lamotrigine: an update of its pharmacology and therapeutic use in epilepsy
    • COI: 1:CAS:528:DyaK2MXptlalsLY%3D, PID: 8536554
    • Fitton A, Goa KL. Lamotrigine: an update of its pharmacology and therapeutic use in epilepsy. Drugs 1995 Oct; 50: 691–713
    • (1995) Drugs , vol.50 , pp. 691-713
    • Fitton, A.1    Goa, K.L.2
  • 4
    • 0030594562 scopus 로고    scopus 로고
    • 2+ currents in cortical neurons: functional implications
    • COI: 1:CAS:528:DyaK28XjvFGisrg%3D, PID: 8831112
    • 2+ currents in cortical neurons: functional implications. Eur J Pharmacol 1996; 307: 113–6
    • (1996) Eur J Pharmacol , vol.307 , pp. 113-116
    • Stefani, A.1    Spadoni, F.2    Siniscalchi, A.3
  • 5
    • 0030454477 scopus 로고    scopus 로고
    • Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones
    • COI: 1:CAS:528:DyaK2sXitFSns74%3D, PID: 9116235
    • Wang S-J, Huang C-C, Hsu K-S, et al. Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones. Neuroreport 1996; 7: 3037–40
    • (1996) Neuroreport , vol.7 , pp. 3037-3040
    • Wang, S.-J.1    Huang, C.-C.2    Hsu, K.-S.3
  • 6
    • 0343472060 scopus 로고    scopus 로고
    • A calcium antagonistic effect of the new antiepileptic drug lamotrigine
    • von Wegerer J, Hesslinger B, Berger M, et al. A calcium antagonistic effect of the new antiepileptic drug lamotrigine. Eur Neuropsychopharmacol 1997 May; 7(2): 77–81
    • (1997) Eur Neuropsychopharmacol , vol.7 , Issue.2 , pp. 77-81
    • von Wegerer, J.1    Hesslinger, B.2    Berger, M.3
  • 7
    • 0031733873 scopus 로고    scopus 로고
    • An electrophysiological analysis of the protective effects of felbamate, lamotrigine, and lidocaine on the functional recovery from in vitro ischemia in rat neocortical slices
    • COI: 1:CAS:528:DyaK1cXnt1Oqsbg%3D, PID: 9826229
    • Siniscalchi A, Zona C, Guatteo E, et al. An electrophysiological analysis of the protective effects of felbamate, lamotrigine, and lidocaine on the functional recovery from in vitro ischemia in rat neocortical slices. Synapse 1998 Dec; 30(4): 371–9
    • (1998) Synapse , vol.30 , Issue.4 , pp. 371-379
    • Siniscalchi, A.1    Zona, C.2    Guatteo, E.3
  • 8
    • 0026304850 scopus 로고
    • Neurochemical and behavioral aspects of lamotrigine
    • COI: 1:CAS:528:DyaK38XitVOlsbY%3D, PID: 1685439
    • Leach MJ, Baxter MG, Critchley MAE, et al. Neurochemical and behavioral aspects of lamotrigine. Epilepsia 1991; 32Suppl 2: S4–8
    • (1991) Epilepsia , vol.32 , pp. S4-S8
    • Leach, M.J.1    Baxter, M.G.2    Critchley, M.A.E.3
  • 9
    • 0028246507 scopus 로고
    • Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents
    • COI: 1:CAS:528:DyaK2cXlsVyku7g%3D, PID: 8084530
    • Rataud J, Debarnot F, Mary V, et al. Comparative study of voltage-sensitive sodium channel blockers in focal ischaemia and electric convulsions in rodents. Neurosci Lett 1994; 172: 19–23
    • (1994) Neurosci Lett , vol.172 , pp. 19-23
    • Rataud, J.1    Debarnot, F.2    Mary, V.3
  • 11
    • 0028959228 scopus 로고
    • Cerebroprotective effect of lamotrigine after focal ischemia in rats
    • COI: 1:CAS:528:DyaK2MXkvF2gs7g%3D, PID: 7839380
    • Smith SE, Meldrum BS. Cerebroprotective effect of lamotrigine after focal ischemia in rats. Stroke 1995; 26: 117–22
    • (1995) Stroke , vol.26 , pp. 117-122
    • Smith, S.E.1    Meldrum, B.S.2
  • 12
    • 0028939058 scopus 로고
    • Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia
    • COI: 1:CAS:528:DyaK2MXkvF2hurc%3D, PID: 7886726
    • Wiard RP, Dickerson MC, Beek O, et al. Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. Stroke 1995; 26: 466–72
    • (1995) Stroke , vol.26 , pp. 466-472
    • Wiard, R.P.1    Dickerson, M.C.2    Beek, O.3
  • 13
    • 0030024979 scopus 로고    scopus 로고
    • w-nitro-L-arginine methyl ester of motoneuron cell death after neonatal axotomy
    • COI: 1:CAS:528:DyaK28XhsVGntb0%3D, PID: 9053787
    • w-nitro-L-arginine methyl ester of motoneuron cell death after neonatal axotomy. Neuroscience 1996; 71(2): 313–25
    • (1996) Neuroscience , vol.71 , Issue.2 , pp. 313-325
    • Casanovas, A.1    Ribera, J.2    Hukkanen, M.3
  • 14
    • 0029879056 scopus 로고    scopus 로고
    • Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases
    • COI: 1:CAS:528:DyaK28XhvFKnsrs%3D, PID: 8684608
    • Schulz JB, Matthews RT, Henshaw DR, et al. Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. Neuroscience 1996; 71(4): 1043–8
    • (1996) Neuroscience , vol.71 , Issue.4 , pp. 1043-1048
    • Schulz, J.B.1    Matthews, R.T.2    Henshaw, D.R.3
  • 15
    • 0030031692 scopus 로고    scopus 로고
    • Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation
    • COI: 1:CAS:528:DyaK2MXhtVSns73F, PID: 8522990
    • Adams J, Collaço-Moraes Y, de Belleroche J, et al. Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation. J Neurochem 1996; 66: 6–13
    • (1996) J Neurochem , vol.66 , pp. 6-13
    • Adams, J.1    Collaço-Moraes, Y.2    de Belleroche, J.3
  • 16
    • 85079127674 scopus 로고    scopus 로고
    • Accessed, Jun 25
    • Prescribing information: Lamictal® (lamotrigine) [online]. Available from URL: http://us.gsk.com/products/assets/us_lamictal.pdf [Accessed 2003 Jun 25]
    • (2003)
  • 17
    • 0036160581 scopus 로고    scopus 로고
    • 1 receptor mediated response in rat brain
    • COI: 1:CAS:528:DC%2BD38XktVOjsw%3D%3D, PID: 11792461
    • 1 receptor mediated response in rat brain. Neurochem Int 2002 Apr; 40(4): 315–9
    • (2002) Neurochem Int , vol.40 , Issue.4 , pp. 315-319
    • Vinod, K.Y.1    Subhash, M.N.2
  • 18
    • 0033871120 scopus 로고    scopus 로고
    • Lamotrigine: a review of its use in childhood epilepsy
    • COI: 1:STN:280:DC%2BD3M%2FmtVSiuw%3D%3D, PID: 10946418
    • Culy CR, Goa KL. Lamotrigine: a review of its use in childhood epilepsy. Paediatr Drugs 2000 Jul; 2(4): 299–330
    • (2000) Paediatr Drugs , vol.2 , Issue.4 , pp. 299-330
    • Culy, C.R.1    Goa, K.L.2
  • 19
    • 0031756758 scopus 로고    scopus 로고
    • Cellular and molecular actions of lamotrigine: possible mechanisms of efficacy in bipolar disorder
    • COI: 1:CAS:528:DyaK1cXns1Srtr8%3D, PID: 9778599
    • Xie X, Hagan RM. Cellular and molecular actions of lamotrigine: possible mechanisms of efficacy in bipolar disorder. Neuropsychobiology 1998 Oct; 38(3): 119–30
    • (1998) Neuropsychobiology , vol.38 , Issue.3 , pp. 119-130
    • Xie, X.1    Hagan, R.M.2
  • 20
    • 0027305506 scopus 로고
    • Seizure severity and the quality of life
    • PID: 8339714
    • Smith D, Chadwick D, Baker G, et al. Seizure severity and the quality of life. Epilepsia 1993; 34Suppl. 5: S31–5
    • (1993) Epilepsia , vol.34 , pp. S31-S35
    • Smith, D.1    Chadwick, D.2    Baker, G.3
  • 21
    • 0027534819 scopus 로고
    • Outcomes of add-on treatment with lamotrigine in partial epilepsy
    • COI: 1:STN:280:DyaK3s3gt1Srtg%3D%3D, PID: 8453943
    • Smith D, Baker G, Davies G, et al. Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia 1993; 34(2): 312–22
    • (1993) Epilepsia , vol.34 , Issue.2 , pp. 312-322
    • Smith, D.1    Baker, G.2    Davies, G.3
  • 22
    • 85079185701 scopus 로고    scopus 로고
    • Lamotrigine add-on therapy is associated with improvement in mood in patients with severe epilepsy [abstract no
    • Jacoby A, Baker G, Bryant-Comstock L, et al. Lamotrigine add-on therapy is associated with improvement in mood in patients with severe epilepsy [abstract no. I.4]. Epilepsia 1996; 37 Suppl. 5: 202
    • (1996) I.4]. Epilepsia , vol.5 , pp. 202
    • Jacoby, A.1    Baker, G.2    Bryant-Comstock, L.3
  • 26
    • 0031422928 scopus 로고    scopus 로고
    • Lamotrigine: pharmacokinetics
    • PID: 9429124
    • Garnett WR. Lamotrigine: pharmacokinetics. J Child Neurol 1997 Nov; 12Suppl. 1: S10–5
    • (1997) J Child Neurol , vol.12 , pp. S10-S15
    • Garnett, W.R.1
  • 27
    • 0023475125 scopus 로고
    • Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans
    • COI: 1:CAS:528:DyaL1cXkvVKmug%3D%3D, PID: 3677542
    • Cohen AF, Land GS, Breimer DD, et al. Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans. Clin Pharmacol Ther 1987; 42: 535–41
    • (1987) Clin Pharmacol Ther , vol.42 , pp. 535-541
    • Cohen, A.F.1    Land, G.S.2    Breimer, D.D.3
  • 28
    • 0026005583 scopus 로고
    • Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy
    • COI: 1:STN:280:DyaK383ovFKlsg%3D%3D
    • Ramsay RE, Pellock JM, Garnett WR, et al. Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy. Epilep Res 1991; 10: 191–200
    • (1991) Epilep Res , vol.10 , pp. 191-200
    • Ramsay, R.E.1    Pellock, J.M.2    Garnett, W.R.3
  • 29
    • 0032920526 scopus 로고    scopus 로고
    • Lamotrigine concentrations in human serum, brain tissue, and tumor tissue
    • COI: 1:CAS:528:DyaK1MXhvVSnt70%3D, PID: 9924904
    • Meyer FP, Banditt P, Schubert A, et al. Lamotrigine concentrations in human serum, brain tissue, and tumor tissue. Epilepsia 1999 Jan; 40: 68–73
    • (1999) Epilepsia , vol.40 , pp. 68-73
    • Meyer, F.P.1    Banditt, P.2    Schubert, A.3
  • 30
    • 0027440140 scopus 로고
    • Lamotrigine clinical pharmacokinetics
    • COI: 1:STN:280:DyaK2c7mtlykug%3D%3D, PID: 8119045
    • Rambeck B, Wolf P. Lamotrigine clinical pharmacokinetics. Clin Pharmacokinet 1993; 25(6): 433–43
    • (1993) Clin Pharmacokinet , vol.25 , Issue.6 , pp. 433-443
    • Rambeck, B.1    Wolf, P.2
  • 31
    • 0012111395 scopus 로고    scopus 로고
    • The disposition of lamotrigine throughout pregnancy [abstract no
    • Berry DJ. The disposition of lamotrigine throughout pregnancy [abstract no. 90]. Ther Drug Monit 1999 Aug; 21: 450
    • (1999) 90]. Ther Drug Monit , vol.21 , pp. 450
    • Berry, D.J.1
  • 32
    • 0034041253 scopus 로고    scopus 로고
    • Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation
    • COI: 1:CAS:528:DC%2BD3cXksFSisbk%3D, PID: 10840403
    • Ohman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 2000 Jun; 41: 709–3
    • (2000) Epilepsia , vol.41 , pp. 703-709
    • Ohman, I.1    Vitols, S.2    Tomson, T.3
  • 33
    • 0025835171 scopus 로고
    • Comparison of lamotrigine pharmacokinetics in young and elderly healthy volunteers
    • Posner J, Holdich T, Crome P. Comparison of lamotrigine pharmacokinetics in young and elderly healthy volunteers. J Pharm Med 1991; 1: 121–8
    • (1991) J Pharm Med , vol.1 , pp. 121-128
    • Posner, J.1    Holdich, T.2    Crome, P.3
  • 34
    • 0033813124 scopus 로고    scopus 로고
    • The effects of lamotrigine on the pharmacokinetics of lithium
    • COI: 1:CAS:528:DC%2BD3cXnt1Kgtbw%3D, PID: 10971302
    • Chen C, Veronese L, Yin Y. The effects of lamotrigine on the pharmacokinetics of lithium. Br J Clin Pharmacol 2000 Sep; 50(3): 193–5
    • (2000) Br J Clin Pharmacol , vol.50 , Issue.3 , pp. 193-195
    • Chen, C.1    Veronese, L.2    Yin, Y.3
  • 35
    • 0029909431 scopus 로고    scopus 로고
    • Bidirectional interaction of valproate and lamotrigine in healthy subjects
    • COI: 1:CAS:528:DyaK28XmsFSktrY%3D, PID: 8823232
    • Anderson GD, Yau MK, Gidal BE, et al. Bidirectional interaction of valproate and lamotrigine in healthy subjects. Clin Pharmacol Ther 1996 Aug; 60: 145–56
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 145-156
    • Anderson, G.D.1    Yau, M.K.2    Gidal, B.E.3
  • 36
    • 24844469546 scopus 로고    scopus 로고
    • Lamotrigine drug interactions in a TDM material [abstract no
    • Böttiger Y, Ståhle L. Lamotrigine drug interactions in a TDM material [abstract no. 84]. Ther Drug Monit 1997 Oct; 19: 568
    • (1997) 84]. Ther Drug Monit , vol.19 , pp. 568
    • Böttiger, Y.1    Ståhle, L.2
  • 37
    • 0141890372 scopus 로고    scopus 로고
    • Population pharmacokinetics of lamotrigine to evaluate interaction with concommitant antiepileptic drugs
    • Edelbroek PM, Segers JP, Gilissen KGPM, et al. Population pharmacokinetics of lamotrigine to evaluate interaction with concommitant antiepileptic drugs. Epilepsia 1996; 37 Suppl. 4: 64
    • (1996) Epilepsia , vol.4 , pp. 64
    • Edelbroek, P.M.1    Segers, J.P.2    Gilissen, K.G.P.M.3
  • 38
    • 24844440287 scopus 로고    scopus 로고
    • Characterization of lamotrigine (LTG) drug interactions using the population approach [abstract no. 3148]
    • Hossain M, Chen C, Ette E. Characterization of lamotrigine (LTG) drug interactions using the population approach [abstract no. 3148]. Pharm Res 1997 Nov; 14(11 Suppl.): S515
    • (1997) Pharm Res , vol.14 , pp. S515
    • Hossain, M.1    Chen, C.2    Ette, E.3
  • 39
    • 0002643323 scopus 로고    scopus 로고
    • Influence of oxcarbazepine and methsuximide on LTG concentrations [abstract]
    • May TW, Rambeck B. Influence of oxcarbazepine and methsuximide on LTG concentrations [abstract]. Epilepsia 1998; 39 Suppl. 2: 25
    • (1998) Epilepsia , vol.2 , pp. 25
    • May, T.W.1    Rambeck, B.2
  • 40
    • 10744229429 scopus 로고    scopus 로고
    • A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder
    • COI: 1:CAS:528:DC%2BD3sXot1Cmsr4%3D
    • Calabrese JR, Bowden CL, Sachs G, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psych 2003; 64(9): 1013–24
    • (2003) J Clin Psych , vol.64 , Issue.9 , pp. 1013-1024
    • Calabrese, J.R.1    Bowden, C.L.2    Sachs, G.3
  • 41
    • 0037385145 scopus 로고    scopus 로고
    • A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder
    • COI: 1:CAS:528:DC%2BD3sXjtlelt74%3D, PID: 12695317
    • Bowden CL, Calabrese JR, Sachs G, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. Arch Gen Psychiatry 2003 Apr; 60(4): 392–400
    • (2003) Arch Gen Psychiatry , vol.60 , Issue.4 , pp. 392-400
    • Bowden, C.L.1    Calabrese, J.R.2    Sachs, G.3
  • 43
    • 0033004838 scopus 로고    scopus 로고
    • A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression
    • COI: 1:CAS:528:DyaK1MXhvVSitbc%3D, PID: 10084633
    • Calabrese JR, Bowden CL, Sachs GS, et al. A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. J Clin Psychiatry 1999 Feb; 60(2): 79–88
    • (1999) J Clin Psychiatry , vol.60 , Issue.2 , pp. 79-88
    • Calabrese, J.R.1    Bowden, C.L.2    Sachs, G.S.3
  • 44
    • 0033697737 scopus 로고    scopus 로고
    • A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders
    • COI: 1:CAS:528:DC%2BD3cXos1Ols7g%3D, PID: 11106131
    • Frye MA, Ketter TA, Kimbrell TA, et al. A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Psychopharmacol 2000 Dec; 20(6): 607–14
    • (2000) J Clin Psychopharmacol , vol.20 , Issue.6 , pp. 607-614
    • Frye, M.A.1    Ketter, T.A.2    Kimbrell, T.A.3
  • 45
    • 85079124938 scopus 로고    scopus 로고
    • (Data on file)
    • GlaxoSmithKline, 2003. (Data on file)
    • (2003)
  • 47
    • 0036854301 scopus 로고    scopus 로고
    • Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management
    • PID: 12444815
    • Calabrese JR, Sullivan JR, Bowden CL, et al. Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management. J Clin Psychiatry 2002 Nov; 63(11): 1012-9
    • (2002) J Clin Psychiatry , vol.63 , Issue.11 , pp. 1012
    • Calabrese, J.R.1    Sullivan, J.R.2    Bowden, C.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.