Synthesis of peptides employing 9-fluorenylmethyl chloroformate as a coupling agent

Letters in Peptide Science

Volumn 10, Issue 1, 2003, Pages 51-55

  Tantry, Subramanyam J ^a   Vasanthakumar, Ganga Ramu ^a   Suresh Babu, Vommina V ^a  

^a BANGALORE UNIVERSITY   (India)

Author keywords

9 fluorenylmethyl chloroformate; Mixed anhydride method; N,O bis trimethylsilyl amino acids; Peptide acids; Racemization free coupling

Indexed keywords

9 FLUORENYLMETHYL CHLOROFORMATE; ACID ANHYDRIDE; AMINO ACID BENZYL ESTER; AMINO ACID DERIVATIVE; AMINO ACID METHYL ESTER; ETHYLDIISOPROPYLAMINE; PEPTIDE; TETRAHYDROFURAN; UNCLASSIFIED DRUG;

ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PEPTIDE SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIZATION;

EID: 1442350564     PISSN: 09295666     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:LIPS.0000014009.88440.14     Document Type: Article

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23. 3): 2.9 (2H, d), 3.7 (3H, s), 4.2 (1H, t), 4.4 (2H, d), 4.8 (1H, m), 5.2 (1H, br), 6.1 (1H, br), 6.2 (1H, br), 7.0-7.8 (18H, ArH).
24. t value 15.39 min).
25. 3): 3.0 (2H, d), 3.6 (3H, s), 4.2 (1H, t), 4.4 (2H, d), 4.7 (1H, t), 6.1 (1H, d), 7.0-7.8 (13H, ArH).