Artificial Cell Bioencapsulation in Macro, Micro, Nano, and Molecular Dimensions: Keynote Lecture

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

Volumn 32, Issue 1, 2004, Pages 1-23

  Chang, Thomas Ming Swi ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Artificial cells; Bioencapsulation; Blood substitutes; Cell therapy; Drug delivery; Encapsulation; Enzyme therapy; Gene therapy; Macrocapsules; Microcapsules; Nanocapsules

Indexed keywords

CELLS; CROSSLINKING; ENZYMES; MICROORGANISMS; TISSUE;

BIOENCAPSULATION; BIOREACTANTS;

BIOTECHNOLOGY;

ANTIOXIDANT; BLOOD SUBSTITUTE;

BIOTECHNOLOGY; CELL ENCAPSULATION; CONFERENCE PAPER; CROSS LINKING; DRUG DELIVERY SYSTEM; ENZYME THERAPY; GENETIC ENGINEERING; HEMOPERFUSION; MOLECULAR DYNAMICS; PHENYLKETONURIA;

ANIMALS; ARTIFICIAL ORGANS; BLOOD SUBSTITUTES; CAPSULES; CELL TRANSPLANTATION; DRUG DELIVERY SYSTEMS; ENZYMES; HUMANS;

EID: 1442324438     PISSN: 10731199     EISSN: None     Source Type: Journal    
DOI: 10.1081/BIO-120028665     Document Type: Conference Paper

References (61)

1. Aebischer, P., Schluep, M., Deglon, N., Joseph, J. M, Hirt, L., Heyd, B., Goddard, M., Hammang, J. P., Zurn, A. D., Kato, A. C., Regli, F., Baetge, E. E. (1996). Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nat. Med. 2:696-699.
2. Bourget, L., Chang, T. M. S. (1986). Phenylalanine ammonia-lyase immobilized in microcapsules for the depleture of phenylalanine in plasma in phenylketonuric rat model. Biochim. Biophys. Acta 883:432-438.
3. Bruni, S., Chang, T. M. S. (1989). Hepatocytes immobilized by microencapsulation in artificial cells: Effects on hyperbiliru-binemia in Gunn Rats. J. Biomat. Artif. Cells and Artif. Org. 17:403-412.
4. Chang, T. M. S. (1957). "Hemoglobin Corpuscles", Report of a research project for Honours Physiology, Medical Library, McGill University. Also reprinted as part of "30 anniversary in artificial red blood cells research". J. Biomaterials. Artificial Cells & Artificial Organs 16:1-9, 1988.
5. Chang, T. M. S. (1964). Semipermeable microcapsules. Science 146:524-525.
6. Chang, T. M. S. (1966). Semipermeable aqueous microcapsules ["artificial cells"]: with emphasis on experiments in an extracorporeal shunt system. Trans. Am. Soc. Artif. Intern. Organs 12:13-19.
7. Chang, T. M. S. (1971a). The in vivo effects of semipermeable microcapsules containing L-asparaginase on 6C3HED lymphosarcoma. Nature 229(528):117-118.
8. Chang, T. M. S. (1971b). Stabilization of enzyme by microencapsulation with a concentrated protein solution or by crosslinking with glutaraldehyde. Biochem. Biophys. Res. Com. 44:1531-1533.
9. Chang, T. M. S. (1972). Artificial Cells. (Available for free online viewing at www.artcell.mcgill.ca), Springfield, C.C.: Thomas Publisher, pp. 1-207.
10. Chang, T. M. S. (1975). Microencapsulated adsorbent hemoperfusion for uremia, intoxication and hepatic failure. Kidney Int. 7:S387-S392.
11. Chang, T. M. S. (1976). Biodegradable semipermeable microcapsules containing enzymes, hormones, vaccines, and other biologicals. J. Bioengineering 1:25-32.
12. Chang, T. M. S. (1995). Artificial cells with emphasis on bioencapsulation in biotechnology. Biotechnology Annual Review 1:267-295.
13. Chang, T. M. S. (1997a). Artificial cells. In: Dulbecco, Renals, editor-in-chief. Encyclopedia of Human Biology. 2nd Ed. San Diego, CA: Academic Press Inc., pp. 457-463.
14. Chang, T. M. S. (1997b). Live E. coli cells to treatment uremia: replies to letters to the editor. Nature Medicine 3:2-3.
15. Chang, T. M. S. (1997c). Blood Substitutes: Principles, Methods, Products and Clinical Trials. (available for free online viewing at www. artcell.mcgill.ca), Vol. 1. Basel: Karger, pp. 1-138.
16. Chang, T. M. S. (1999). Artificial blood: a prospective. Trends in Biotechnology 17:61-67.
17. Chang, T. M. S. (2001). Bioencapsulated hepatocytes for experimental liver support. Journal of Hepatology 34:148-149.
18. Chang, T. M. S. (2002). Oxygen carriers. Current Opinion in Investigational Drugs 3(8):1187-1190.
19. Chang, T. M. S. (2003). New generations of red blood cell substitutes. J. Internal Medicine. 253:527-535.
20. Chang, T. M. S., Poznansky, M. J. (1968). Semipermeable microcapsules containing catalase for enzyme replacement in acatalsaemic mice. Nature 218(5138):242-245.
21. Chang, T. M. S., Prakash, S. (1998). Therapeutic uses of microencapsulated genetically engineered cells. Molecular Medicine Today 4:221-227.
22. Chang, T. M. S., Prakash, S. (2001). Procedure for microencapsulation of enzymes, cells and genetically engineered microorganisms. Molecular Biotechnology 17:249-260.
23. Chang, T. M. S., Yu, W. P. (1998). Nanoencapsulation of hemoglobin and red blood cell enzymes based on nanotechnology and biodegradable polymer. In: Chang, T. M. S., ed. Blood Substitutes: Principles, Methods, Products and Clinical Trials. Vol. 2. Basel: Karger, pp. 216-231.
24. Chang, T. M. S., Bourget, L., Lister, C. (1995). New theory of enterorecirculation of amino acids and its use for depleting unwanted amino acids using oral enzyme-artificial cells, as in removing phenylalanine in phenylketonuria. Artificial Cells, Blood Substitutes & Immobilization Biotechnology 25:1-23.
25. Chang, T. M. S., MacIntosh, F. C., Mason, S. G. (1966). Semipermeable aqueous microcapsules: 1. Preparation and properties. Can. J. Physiol. Pharmacol. 44:115-128.
26. Chang, T. M. S., Powanda, D., Yu, W. P. (2003). Analysis of polyethylene-glycol-polylactide nano-dimension artificial red blood cells in maintaining systemic hemoglobin levels and prevention of methemoglobin formation. Artif. Cells, Blood Substitutes & Biotechnology, An International Journal 31(3):231-248.
27. Chow, K. M., Liu, Z. C., Prakash, S., Chang, T. M. S. (2003). Free and icroencapsulated Lactobacillus and effects of metabolic induction on Urea Removal Artificial Cells. Blood Substitutes & Biotechnology 33:425-434.
28. D'Agnillo, F., Chang, T. M. S. (1998a). Polyhemoglobin-superoxide dismutase, catalase as a blood substitute with antioxidant properties. Nature Biotechnology 16(7):667-671.
29. D'Agnillo, F., Chang, T. M. S. (1998b). Absence of hemoprotein-associated free radical events following oxidant challenge of crosslinked hemoglobin-superoxide dismutase-catalase. Free Radical Biology & Medicine 24(6):906-912.
30. Dionne, K. E., Cain, B. M., Li, R. H., Bell, W. J., Doherty, E. J., Rein, D. H., Lysaght, M. J., Gentile, F. T. (1996). Transport characterization of membranes for immunoisolation. Biomaterials 17:257-266.
31. Gould, S. A., Sehgal, L. R., Sehgal, H. L., DeWoskin, R., Moss, G. S. (1998). The clinical development of human polymerized hemoglobin. In: Chang, T. M. S., ed. Blood Substitutes: Principles, Methods, Products and Clinical Trials. Vol. 2. Basel: Karger, pp. 12-28.
32. Gould, S. A., Moore, E. E., Hoyt, D. B., Ness, P. M., Norris, E. J., Carson, J. L., Hides, GA., Freeman, I. H. G., DeWoskin, R., Moss, G. S. (2002). The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable. Journal of the American College of Surgeons 195:445-452.
33. Hunkeler, D., Prokop, A., A. D., Rajotte, R., Sefton, M., eds. (1999). Bioartificial Organs A: Technology, Medicine and Material. Ann N.Y. Acad. Sci, 1999 Vol. 875 Acad. Sci., 831, pp. 271-279.
34. Kulitreibez, W. M., Lauza, P. P., Cuicks, W. L., eds. (1999). Cell Encaptulation Technology and Therapy, Boston: Burkhauser, pp. 1-450.
35. Lim, F., Sun, A. M. (1980). Microencapsulated islets as bioartificial endocrine pancreas. Science 210:908-909.
36. Liu, Z., Chang, T. M. S. (2000). Effects of bone marrow cells on hepatocytes: when co-cultured or co-encapsulated together. Artif Cells, Blood Substitutes & Immob. Biotechnology, An International Journal 28(4):365-374.
37. Liu, Z. C., Chang, T. M. S. (2002). Transplantation of co-encapsulated hepatocytes and marrow stem and cells into rats. Artificial Cells, Blood Substitutes & Immob. Biotechnology, An International Journal 30:99-112.
38. Liu, Z. C., Chang, T. M. S. (2003). Coencapsulation of stem cells and hepatocytes: in-vitro conversion of ammonia and in-vivo studies on the lowering of bilirubin in gunn rats after transplantation. Interantional Journal of Artificial Organs 26(6):491-497.
39. Liu, J., Jia, X., Zhang, J., Xiang, G., Hu, W., Zhou, Y. (2002). Study on a novel strategy to treatment of phenylketonuria. Artificial Cells, Blood Substitutes & Immobilization Biotechnology 30:243-258.
40. Orive, G., Hernandez, R. M., Gascon, A. R., Calafiore, R., Chang, T. M. S. (2003). Cell encapsulation: promise and progress. Nature Medicine 9:104-107.
41. Palmour, R. M., Goodyer, P., Reade, T., Chang, T. M. S. (1989). Microencapsulated xanthine oxidase as experimental therapy in Lesch-Nyhan Disease. Lancet 2(8664):687-688.
42. Pearce, L. B., Gawryl, M. S. (1998). Overview of preclinical and clinical efficacy of biopure's HBOCs. In: Chang, T. M. S., ed. Blood Substitutes: Principles, Methods, Products and Clinical Trials. Vol. 2. Basel: Karger, pp. 82-98.
43. Philips, W. T., Klpper, R. W., Awasthi, V. D., Rudolph, A. S., Cliff, R., Kwasiborski, V. V., Goins, B. A. (1999). Polyethylene glycomodified liposome-encapsulated hemoglobin: a long circulating red cell substitute. J. Pharm. Exp. Therapeutics 288:665-670.
44. Powanda, D., Chang, T. M. S. (2002). Cross-linked polyhemoglobin-superoxide dismutase-catalase supplies oxygen without causing blood brain barrier disruption or brain edema in a rat model of transient global brain ischemia-reperfusion. Artificial Cells, Blood Substitutes & Immob. Biotechnology. Ah International Journal 30:25-42.
45. Poznansky, M. J., Chang, T. M. S. (1974). Comparison of the enzyme kinetics and immunological properties of catalase immobilized by microencapsulation and catalase in free solution for enzyme replacement. Biochim. Biophys. Acta 334:103-115.
46. Prakash, S., Chang, T. M. S. (1996). Microencapsulated genetically Engineered live E. coli DH5 cells administered orally to maintain normal plasma urea level in uremic rats. Nature Medicine 2(8):883-887.
47. Razack, S., D'Agnillo, F., Chang, T. M. S. (1997). Effects of Polyhemoglobin-catalase-superoxide dismutase on oxygen radicals in an ischemia-reperfusion rat intestinal model. Artificial Cells, Blood Substitutes and Immobilization Biotechnology. 25:181-192.
48. Rudolph, A. S., Rabinovici, R., Feuerstein, G. Z., eds. (1997). Red Blood Cell Substitutes. N.Y.: Marcel Dekker Inc, pp. 1-485.
49. Sarkissian, C. N., Shao, Z., Blain, F., Peevers, R., Su, H., Heft, R., Chang, T. M. S., Scriver, C. R. (1999). A different approach to treatment of phenylketonuria: phenylalanine degradation with recombinant phenylalanine ammonia lyase. Proc. Natl. Acad. Sci. 96:2339-2344.
50. Sprung, J., Kindscher, J. D., Wahr, J. A., Levy, J. H., Monk, T. G., Moritz, M. W., O'Hara, P. J. (2002). The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized, single-blinded trial. Anesth. Analg. 94:799-808.
51. Tsuchida, E., ed. (1998). Blood Substitutes: Present and Future Perspectives. Amsterdam: Elsevier, pp. 1-267.
52. Winchester, J. F. (1988). Replacement of renal function by dialysis. In: Maher, J. F., ed. Hemoperfusion. Boston: Kluwer Academic Publisher, pp. 439-592.
53. Winslow, R. (2003). Current status of blood substitute research: towards a new paradigm. J. Int. Med. 253:508-517.
54. Wong, H., Chang, T. M. S. (1986). Bioartificial liver: implanted artificial cells microencapsulated living hepatocytes increases survival of liver failure rats. Int. J. Artif Organs 9:335-336.
55. Wong, H., Chang, T. M. S. (1988). The viability and regeneration of artificial cell microencapsulated rat hepatocyte xenograft transplants in mice. J. Biomaterials, Artificial Cells and Artificial Organs 16:731-740.
56. Wong, H., Chang, T. M. S. (1991a). Microencapsulation of cells within alginate poly-L-lysine microcapsules prepared with standard single step drop technique: histologically identified membrane imperfections and the associated graft rejection. Biomaterials, Artificial Cells and Immobilization Biotechnology 19:675-686.
57. Wong, H., Chang, T. M. S. (1991b). A novel two-step procedure for immobilizing living cells in microcapsule for improving xenograft survival. Biomaterials, Artificial Cells and Immobilization Biotechnology 19:687-698.
58. Yu, W. P., Chang, T. M. S. (1994). Submicron biodegradable polymer membrane hemoglobin nanocapsules as potential blood substitutes: A preliminary report. J. of Artificial Cells, Blood Subtitutes and Immobilization Biotechnology (Guest editor: R. Winslow) 22:889-894.
59. Yu, B. L., Chang, T. M. S. (2004). Effects of combined oral administration and intravenous injection on maintaining decreased systemic tyrosine levels in rats. Artificial Cells, Blood Substitutes & Biotechnology, An International Journal 34:129-147.
60. Yu, W. P., Wong, J., Chang, T. M. S. (1998). Preparation and characterization of polylactic acid microcapsules containing ciprofloxacin for controlled release. J. Microencapsulation 15:515-523.
61. Yu, W. P., Wong, J. P., Chang, T. M. S. (1999). Biodegradable polylactic acid nanocapsules containning ciprofloxacin: preparation and characterization. Artif Cells, Blood Substitutes & Immob. Biotechnology, An International Journal 27(3):263-278.