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Volumn 8, Issue 5, 2003, Pages 555-558
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Development of a screening assay to measure the loss of antibacterial activity in the presence of proteins: Its use in optimizing compound structure
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Author keywords
Albumin; Antibacterials; Lead optimization; Protein binding; S. aureus
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Indexed keywords
ANTIINFECTIVE AGENT;
BOVINE SERUM ALBUMIN;
HUMAN SERUM ALBUMIN;
PENICILLIN G;
PROTEIN;
ANTIBACTERIAL ACTIVITY;
ARTICLE;
ASSAY;
DRUG DETERMINATION;
DRUG SCREENING;
HIGH THROUGHPUT SCREENING;
HYDROPHOBICITY;
MACROMOLECULE;
MEASUREMENT;
MINIMUM INHIBITORY CONCENTRATION;
PRIORITY JOURNAL;
PROTEIN BINDING;
PROTEIN STRUCTURE;
PROTEIN TARGETING;
STAPHYLOCOCCUS AUREUS;
STOICHIOMETRY;
CHEMISTRY;
DOSE RESPONSE;
DRUG EFFECT;
METABOLISM;
METHODOLOGY;
MICROBIOLOGICAL EXAMINATION;
STATISTICAL MODEL;
STRUCTURE ACTIVITY RELATION;
BOVINAE;
STAPHYLOCOCCUS AUREUS;
ANTI-BACTERIAL AGENTS;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DRUG EVALUATION, PRECLINICAL;
LINEAR MODELS;
MICROBIAL SENSITIVITY TESTS;
PROTEINS;
SERUM ALBUMIN, BOVINE;
STAPHYLOCOCCUS AUREUS;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 1442317136
PISSN: 10870571
EISSN: None
Source Type: Journal
DOI: 10.1177/1087057103256917 Document Type: Article |
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Times cited : (8)
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References (8)
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