Deriving components of genetic variance for multilocus models

Genetic Epidemiology

Volumn 14, Issue 6, 1997, Pages 1131-1136

  Tiwari, Hemant K ^a   Elston, Robert C ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Complex diseases; Dominance; Epistasis; Sibpairs; Variance components

Indexed keywords

ALLELE; CONFERENCE PAPER; GENE FREQUENCY; GENERAL ASPECTS OF DISEASE; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE; INHERITANCE; MODEL; SIBLING; VARIANCE;

ALLELES; CHROMOSOME MAPPING; EPISTASIS, GENETIC; FEMALE; GENE FREQUENCY; GENETIC DISEASES, INBORN; HUMANS; LINKAGE (GENETICS); MALE; MATCHED-PAIR ANALYSIS; MODELS, GENETIC; NUCLEAR FAMILY; PENETRANCE; VARIATION (GENETICS);

EID: 0031442624     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1997)14:6<1131::AID-GEPI95>3.0.CO;2-H     Document Type: Conference Paper

References (10)

1. Cockerham CC (1954): An extension of the concept of partitioning hereditary variance for analysis of covariances among relatives when epistasis is present. Genetics 39:859-882.
2. Eaves LJ (1994): Effect of genetic architecture on the power of human linkage studies to resolve the contribution of quantitative trait loci. Heredity 72:175-192.
3. Greenberg DA, Hodge SE (1989): Linkage analysis under "random" and "genetic" reduced penetrance. Genet Epidemiol 6:259-264.
4. Kojima K (1959): Role of epistasis and overdominance in stability of equilibria with selection. Proc Natl Acad Sci USA 45:984-989.
5. Li CC (1988): "First Course in Population Genetics." Pacific Grove, CA: The Boxwood Press.
6. Neuman RJ, Rice JP (1992): Two-locus models of disease. Genet Epidemiol 9:347-365.
7. Risch N, Zhang H (1995): Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268:1584-1589.
8. Risch N, Zhang H (1996): Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. Am J Hum Genet 58:836-843.
9. Schork NJ, Boehnke M, Terwilliger JD, Ott J (1993): Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. Am J Hum Genet 53:1127-1136.
10. Tiwari HK, Elston RC (in press): Linkage of multilocus components of variance to polymorphic markers. Ann Hum Genet.