Insulin Resistance as a Link between Affective Disorder and Alzheimer's Disease: A Hypothesis in Need of Further Refinement

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 59, Issue 2, 2004, Pages 185-187

  Lyketsos, Constantine G ^a,b   Lee, Hochang ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; BRAIN DISEASE; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; DISEASE ASSOCIATION; HUMAN; INSULIN RESISTANCE; MAJOR DEPRESSION; MOOD DISORDER; NOTE; PRIORITY JOURNAL;

EID: 1442306971     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note

References (35)

1. Rasgon N, Jarvik L. Insulin resistance, affective disorders, and Alzheimer's disease: review and hypothesis. J Gerontol Med Sci. 2004;59A:178-183.
2. Eaton WW, Anthony JC, Gallo J, et al. Natural history of Diagnostic Interview Schedule DSM-IV major depression. Arch Gen Psychiatry. 1997;54:993-999.
3. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease: the Nun Study. JAMA. 1997;277:813-817.
4. Adecola C, Gorelick PB. Converging pathogenic mechanisms in vascular and neurodegenerative dementia. Stroke. 2003;34:335-337.
5. Grippo AJ, Johnson AK. Biological mechanisms in the relationship between depression and heart disease. Neurosci Biobehav Rev. 2002; 26:941-962.
6. Jorm AF. Is depression a risk factor for dementia or cognitive decline? A review. Gerontology. 2000;46:219-227.
7. Agbayewa MO. Earlier psychiatric morbidity in patients with Alzheimer's disease. J Am Geriatr Soc. 1986;34:561-564.
8. Wetherell JL, Gatz M, Johansson B, Pedersen NL. History of depression and other psychiatric illness as risk factors for Alzheimer disease in a twin sample. Alzheimer Dis Assoc Disord. 1999;13:47-52.
9. Speck CE, Kukull WA, Brenner DE, et al. History of depression as a risk factor for Alzheimer's disease. Epidemiology. 1995;6:366-369.
10. Green RC, Cupples AC, Kurz A, et al. Depression as a risk factor for Alzheimer Disease: the MIRAGE study. Arch Neurol. 2003;60: 753-759.
11. Lyketsos CG, Nestadt G, Cwi J, Heithoff K, Eaton WW. The Life Chart Interview: a life calendar interview method to describe the course of psychopathology. Intl J Meth Psychiatr Res. 1994;4:143-155.
12. Buntinx F, Kester A, Bergers J, Knottnerus JA. Is depression in elderly people followed by dementia? A retrospective cohort study based in general practice. Age Ageing. 1996;25:231-233.
13. Devanand DP, Sano M, Tang MX, et al. Depressed mood and the incidence of Alzheimer's disease in the elderly living in the community. Arch Gen Psychiatry. 1996:53:175-182.
14. Chen P, Ganguli M, Mulsant BH, Dekosky ST. The temporal relationship between depressive symptoms and dementia: a community based prospective study. Arch Gen Psychiatry. 1999;56:261-266.
15. Geerlings MI, Schoeveers RA, Beekman ATF, et al. Depression and risk of cognitive decline and Alzheimer's disease. Br J Psychiatry. 2000;176:568-575.
16. Palsson S, Aevarsson O, Skoog I. Depression, cerebral atrophy, cognitive performance and incidence of dementia. Br J Psychiatry. 1999; 174:249-253.
17. Kessing LV, Mortensen PB, Bolgwig TG. Clinical consequences of sensitization in affective disorder: a case register study. J Affect Disord. 1998;47:41-47.
18. Lee HB, Lyketsos CG. Depression in Alzheimer's disease: heterogeneity and related issues. Biol Psychiatry. 2003;54:353-362.
19. Musselman DL, Betan E, Larsen H, Phillips LS. Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment. Biol Psychiatry. 2003;54:317-329.
20. Gasparini L, Netzer WJ, Greengard P, Xu H. Does insulin dysfunction play a role in Alzheimer's disease? Trends Pharm Sci. 2002;23: 288-293.
21. Bohrmann B. Endogenous proteins controlling amyloid β polymerization. Possible implications for β-amyloid formation in the central nervous system and in peripheral tissues. J Biol Chem. 1999;274: 15990-15995.
22. Glumer C, Jorgensen T, Borch-Johnsen K, for the Inter99 study. Prevalences of diabetes and impaired glucose regulation in a Danish population: the Inter99 study. Diabetes Care. 2003;26:2335-2340.
23. Alexopoulos GS. Vascular disease, depression, and dementia. J Am Geriatr Soc. 2003;51:1178-1180.
24. Glassman AH, Shapiro PA. Depression and the course of coronary artery disease. Am J Psychiatry. 1998;155:4-11.
25. Musselman DL, Evans DL, Nemeroff CB. The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment. Arch Gen Psychiatry. 1998;55:580-592.
26. Bjorkerud S. Effect of adrenocortical hormones on the integrity of rat aortic endothelium. In: Schettler G, Weizel A, eds. Proceedings of the 3rd International Symposium on Atherosclerosis. Berlin, Germany: Springer-Verlag; 1973:245.
27. Nahas GG, Brunson JG, King WM, Cavert HM. Functional and morphologic changes in heart lung preparations following administration of adrenal hormones. Am J Clin Pathol. 1958;34:717-729.
28. Kemper JW, Baggenstoss AH, Slocumb CH. The relationship of therapy with cortisone to the incidence of vascular lesions in rheumatoid arthritis. Ann Intern Med. 1957;46:831-851.
29. Ross R, Harker L. Hyperlipidemia and atherosclerosis. Science. 1976; 193:1094-1100.
30. Ohira T, Iso H, Satoh S, et al. Prospective study of depressive symptoms and risk of stroke among Japanese. Stroke. 2001;32:903-908.
31. Simons LA, McCallum J, Friendlander Y, Simons J. Risk factors for ischemic stroke: Dubbo Study of the Elderly. Stroke. 1998;29: 1341-1346.
32. Simons LA. Is depression a risk factor for ischemic stroke? Stroke. 2001;32:907-908.
33. Jonas BS, Mussolino ME. Symptoms of depression as a prospective risk factor for stroke. Psychosom Med. 2000;62:463-471.
34. Everson S, Robert R, Goldberg D, Kaplan G. Depressive symptoms and increased risk of stroke mortality over a 29-year period. Arch Intern Med. 1998;158:1133-1138.
35. Larson SL, Owens PL, Ford D, Eaton WW. Depressive disorder, dysthymia, and risk of stroke: thirteen-year follow-up from the Baltimore Epidemiologic Catchment Area Study. Stroke. 2001:32:1979-1983.