Effects of genioglossal response to negative airway pressure on upper airway collapsibility during sleep

Journal of Applied Physiology

Volumn 80, Issue 5, 1996, Pages 1466-1474

  Philip Joët, François ^a   Marc, Isabelle ^a   Sériès, Frédéric ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

critical pressure; sleep apnea hypopnea

Indexed keywords

DIAZEPAM; PLACEBO;

ADULT; AIRWAY PRESSURE; ARTICLE; BREATHING MUSCLE; BREATHING PATTERN; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ELECTROMYOGRAPHY; ESOPHAGUS PRESSURE; HUMAN; HUMAN EXPERIMENT; LUNG VOLUME; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SLEEP; TONGUE; UPPER RESPIRATORY TRACT;

EID: 0029976342     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.80.5.1466     Document Type: Article

References (36)

1. Aronson, R. M., D. W. Carley, E. Önal, J. Wilborn, and M. Lopata. Upper airway activity and the thoracic volume dependence of upper airway resistance. J. Appl. Physiol. 70: 430-438, 1991.
2. Aronson, R. M., E. Önal, D. W. Carley, and M. Lopata. Upper airway and respiratory muscle responses to continuous negative airway pressure. J. Appl. Physiol. 66: 1373-1382, 1989.
3. Baydur, A., P. Behrakis, W. A. Zin, M. Jaeger, and J. Milic-Emili. A simple method for assessing the validity of esophageal balloon technique. Am. Rev. Respir. Dis. 126: 788-791, 1982.
4. Brouillette, E. T., and B. T. Thach. A neuromuscular mechanism maintaining extrathoracic airway patency. J. Appl. Physiol. 46: 772-779, 1979.
5. Doble, E. A., S. L. Knuth, J. A. Daubenspeck, and D. Bartlett. A noninvasive intraoral electromyographic electrode for genioglossus muscle. J. Appl. Physiol. 58: 1378-1382, 1985.
6. Gleadhill, I. C., A. R. Schwartz, N. Schubert, R. A. Wise, A. R. Gold, S. Permutt, and P. Smith. Upper airway collapsibility in snorers and in patients with obstructive hypopnea and apnea. Am. Rev. Respir. Dis. 143: 1300-1303, 1991.
7. Guilleminault, C., M. W. Hill, F. B. Simmons, and W. C. Dement. Obstructive sleep apnea: electromyographic and fiber-optic studies. Exp. Neurol. 62: 48-67, 1978.
8. Hida, W., H. Kurosawa, S. Okabe, Y. T. Chung, J. Midorikawa, C. Shindoh, Y. Kikuchi, and T. Takishima. Effects of hypoglossal nerve stimulation on upper airway pressure-volume behavior in anesthetized dogs (Abstract). Am. Rev. Respir. Dis. 145: A211, 1992.
9. Isono, S., D. L. Morrison, S. H. Launois, T. R. Feroah, W. A. Whitelaw, and J. E. Remmers. Static mechanics of the velopharynx of patients with obstructive sleep apnea. J. Appl. Physiol. 75: 148-154, 1993.
10. Koenig, J. S., and B. T. Thach. Effects of mass loading on the upper airway. J. Appl. Physiol. 64: 2294-2299, 1988.
11. Leiter, J. C. Analysis of pharyngeal resistance and genioglossal EMG activity using a model of orifice flow. J. Appl. Physiol. 73: 576-583, 1992.
12. Leiter, J. C., and J. A. Daubenspeck. Selective activation of the genioglossus in humans. J. Appl. Physiol. 68: 2581-2187, 1990.
13. Leiter, J. C., S. L. Knuth, and D. Bartlett. The effect of sleep deprivation on activity of the genioglossus muscle. Am. Rev. Respir. Dis. 132: 1242-1245, 1985.
14. Leiter, J. C., S. L. Knuth, and D. Bartlett. Dependence of pharyngeal resistance on genioglossal EMG activity, nasal resistance, and airflow. J. Appl. Physiol. 73: 584-590, 1992.
15. Leiter, J. C., S. L. Knuth, R. C. Krol, and D. Bartlett. The effect of diazepam on genioglossal muscle activity in normal human subjects. Am. Rev. Respir. Dis. 132: 216-219, 1985.
16. Mathew, O. Upper airway negative-pressure effects on respiratory activity of upper airway muscles. J. Appl. Physiol. 56: 500-505, 1984.
17. Mathew, O. P., Y. Abu-Osba, and B. T. Thach. Influence of upper airway pressure changes on genioglossus muscle respiratory activity. J. Appl. Physiol. 52: 438-444, 1982.
18. Mezzanotte, W. S., D. J. Tangel, and D. P. White. Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). J. Clin. Invest. 89: 1571-1579, 1992.
19. Morrison, D. L., S. H. Launois, S. Isono, T. R. Feroah, W. A. Whitelaw, and J. E. Remmers. Pharyngeal narrowing and closing pressures in patients with obstructive sleep apnea. Am. Rev. Respir. Dis. 148: 606-611, 1993.
20. Neter, J., W. Wasserman, and M. H. Kutner. Applied Linear Statistical Models (2nd ed.). Homewood, IL: Irwin, 1985, p. 109-141.
21. Oliven, A., M. Odeh, and N. Gavriely. Effect of hypercapnia on upper airway resistance and collapsibility in anesthetized dogs. Respir. Physiol. 75: 29-38, 1989.
22. Oliven, A., R. Schnall, M. Odeh, and G. Pillar. Reduction of transpharyngeal resistance in sleeping humans by electrically induced genioglossus contraction (Abstract). Am. Rev. Respir. Dis. 145: A170, 1992.
23. Roberts, J. L., W. R. Reed, and B. T. Thach. Assessment of pharyngeal airway stability in normal and micrognathic infants. J. Appl. Physiol. 58: 290-299, 1985.
24. Schwartz, A. R., A. R. Gold, R. A. Wise, S. Permutt, and P. Smith. Effect of weight loss on upper airway collapsibility in obstructive sleep apnea. Am. Rev. Respir. Dis. 144: 494-498, 1992
25. Schwartz, A. R., N. Schubert, W. Rothman, F. Godley, B. Marsh, D. Eisele, J. Nadeau, S. Permutt, I. Gleadhill, and P. Smith. Effect of uvulopalatopharyngoplasty on upper airway collapsibility in obstructive sleep apnea. Am. Rev. Respir. Dis. 145: 527-532, 1992.
26. Schwartz, A. R., P. L. Smith, R. A. Wise, A. R. Gold, I. Bankman, and S. Permutt. Effect of positive nasal pressure on upper airway pressure-flow relationships. J. Appl. Physiol. 66: 1626-1634, 1989.
27. Sériès, F., Y. Cormier, and M. Desmeules. Influence of passive changes of lung volume on upper airways. J. Appl. Physiol. 68: 2159-2164, 1990.
28. Sériès, F., and I. Marc. Effects of continuous negative airway pressure-related lung deflation on upper airway collapsibility. J. Appl. Physiol. 75: 1222-1225, 1993.
29. Sériès, F., and I. Marc. Influence of lung volume dependence of upper airway resistance during continuous negative airway pressure. J. Appl. Physiol. 77: 840-844, 1994.
30. Sériès, F., N. Roy, and I. Marc. Effects of sleep deprivation and sleep fragmentation on upper airway collapsibility in normal subjects. Am. J. Respir. Crit. Care Med. 150: 481-485, 1994.
31. Smith, P. I., R. A. Wise, A. R. Gold, A. R. Schwartz, and S. Permutt. Upper airway pressure-flow relationships in obstructive sleep apnea. J. Appl. Physiol. 64: 789-795, 1988.
32. Strohl, K. P., and S. Redline. Nasal CPAP therapy, upper airway muscle activation, and obstructive sleep apnea. Am. Rev. Respir. Dis. 134: 555-558, 1986.
33. Sullivan, C. E., F. G. Issa, M. Berthon-Jones, and N. A. Saunders. Pathophysiology of sleep apnea. In: Sleep and Breathing, edited by N. A. Saunders and C. E. Sullivan. New York: Dekker, 1984, vol. 21, p. 299-363. (Lung Biol. Health Dis. Ser.)
34. Surrat, P. M., R. F. McTier, and S. C. Wilhoit. Collapsibility of the nasopharyngeal airway in obstructive sleep apnea. Am. Rev. Respir. Dis. 132: 967-971, 1985.
35. Van Der Touw, T., N. O'Neil, A. Brancastisano, T. Amis, J. Wheatley, and L. A. Engel. Respiratory-related activity of soft palate muscles: augmentation by negative upper airway pressure. J. Appl. Physiol. 76: 424-432, 1994.
36. Wasicko, M. J., D. A. Hutt, R. A. Parisi, J. A. Neubaeur, R. Mezrich, and N. H. Edelman. The role of vascular tone in the control of upper airway collapsibility. Am. Rev. Respir. Dis. 141: 1569-1577, 1990.