In Vitro Evolution Predicts that the IMP-1 Metallo-β-Lactamase Does Not Have the Potential to Evolve Increased Activity against Imipenem

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 3, 2004, Pages 1032-1033

  Hall, Barry G ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; ENZYME VARIANT; IMIPENEM; INOSINE PHOSPHATE; INOSINE PHOSPHATE 1 METALLO BETA LACTAMASE; METALLOPROTEIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; GENE LIBRARY; GENE MUTATION; GENETIC SELECTION; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; SCREENING; SERRATIA MARCESCENS;

BETA-LACTAMASES; DRUG RESISTANCE, BACTERIAL; EVOLUTION; GENE LIBRARY; IMIPENEM; MUTATION; PLASMIDS; SERRATIA MARCESCENS; THIENAMYCINS;

EID: 1442275597     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.3.1032-1033.2004     Document Type: Article

References (12)

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3. Barlow, M., and B. G. Hall. 2003. Experimental prediction of the natural evolution of antibiotic resistance. Genetics 163:1237-1241.
4. Barlow, M., and B. G. Hall. 2002. Predicting evolutionary potential: in vitro evolution accurately reproduces natural evolution of the TEM β-lactamase. Genetics 160:823-832.
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6. Hall, B. G. 2002. In vitro Evolution Simulator, version 1.2. University of Rochester, Rochester, N.Y.
7. IMP among clinically isolated strains of Serratia marcescens. Antimicrob. Agents Chemother. 39:824-829.
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10. IMP allelic variants carried by gene cassettes of different phylogeny. Antimicrob. Agents Chemother. 44:1229-1235.
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