One-Carbon Chain Extension of Esters to α-Chloroketones: A Safer Route without Diazomethane

Journal of Organic Chemistry

Volumn 69, Issue 5, 2004, Pages 1629-1633

  Wang, Dengjin ^a   Schwinden, Mark D ^a,b   Radesca, Lilian ^a,c   Patel, Bharat ^a   Kronenthal, David ^a   Huang, Ming Hsing ^a   Nugent, William A ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b SCYNEXIS Inc   (United States)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; CHLORINE COMPOUNDS; DRUG PRODUCTS; METHANE;

EPIMERIZATION; ONE-CARBON CHAIN EXTENSION; PHARMACEUTICAL INTERMEDIATES;

ESTERS;

ALANINE; ALPHA CHLOROKETONE DERIVATIVE; CARBON; DIAZOMETHANE; DIMETHYL SULFOXIDE; DIMETHYLSULFOXONIUM METHYLIDE; EPOXIDE; HYDROCHLORIC ACID; KETONE DERIVATIVE; PHENYLALANINE METHYL ESTER; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; EPIMERIZATION; ORGANIC CHEMISTRY; SYNTHESIS;

AMINO ACID CHLOROMETHYL KETONES; DIAZOMETHANE; ESTERS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE;

EID: 1442275482     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo035733r     Document Type: Article

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