Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals

Cytogenetic and Genome Research

Volumn 102, Issue 1-4, 2003, Pages 42-47

  Winter, A ^a   Van Eckeveld, M ^a   Bininda Emonds, O R P ^a   Habermann, F A ^a   Fries, R ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; DIACYLGLYCEROL DERIVATIVE; DIACYLGLYCEROL TRANSFERASE 2; LYSINE; MILK FAT; MONOACYLGLYCEROL; MONOACYLGLYCEROL TRANSFERASE 1; MONOACYLGLYCEROL TRANSFERASE 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BREEDING; CATTLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME; CHROMOSOME 15Q; CONTROLLED STUDY; DAIRY PRODUCT; DNA POLYMORPHISM; DNA STRUCTURE; EXON; FAT INTAKE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DUPLICATION; GENE FREQUENCY; GENE LOCATION; GENE LOSS; GENE MAPPING; GENE SILENCING; GENE STRUCTURE; GENETIC CODE; GENETIC ORGANIZATION; GENOME ANALYSIS; HUMAN; HUMAN CELL; HUMAN VERSUS ANIMAL COMPARISON; HYDROPHILICITY; HYDROPHOBICITY; INTRON; LIPID STORAGE; LIPOGENESIS; MAMMAL; MISSENSE MUTATION; MOLECULAR CLONING; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; RODENT; TANDEM REPEAT;

ACYLTRANSFERASES; ANIMALS; CATTLE; CHROMOSOMES, ARTIFICIAL, BACTERIAL; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; DATABASES, GENETIC; DIACYLGLYCEROL O-ACYLTRANSFERASE; EXONS; GENOME; HUMANS; INTRONS; MICE; MOLECULAR SEQUENCE DATA; PHYSICAL CHROMOSOME MAPPING; POLYMORPHISM, GENETIC; RATS; SEQUENCE ANALYSIS, DNA;

BOS; BOS TAURUS; BOVINAE; MAMMALIA; RODENTIA;

EID: 1442274754     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000075723     Document Type: Article

References (26)

1. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ: Basic local alignment search tool. J molec Biol 215:403-410 (1990).
2. Boguski MS, Lowe TM, Tolstoshev CM: dbEST database for "expressed sequence tags". Nature Genet 4:332-333 (1993).
3. Breathnach R, Benoist C, O'Hare K, Gannon F, Chambon P: Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc natl Acad Sci, USA 75:4853-4857 (1978).
4. Cao J, Lockwood J, Burn P, Shi Y: Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2. J biol Chem 278:13860-13866 (2003).
5. Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV Jr: Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc natl Acad Sci, USA 95:13018-13023 (1998).
6. Cases S, Stone SJ, Zhou P, Yen E, Tow B, Lardizabal KD, Voelker T, Farese RV Jr: Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J biol Chem 276:38870-38876 (2001).
7. Cheng D, Nelson TC, Chen J, Walker SG, Wardwell-Swanson J, Meegalla R, Taub R, Billheimer JT, Ramaker M, Feder JN: Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption. J biol Chem 278:13611-13614 (2003).
8. Ewing B, Green P: Base-calling of automated sequencer traces using phred. II. Error probabilities. Genome Res 8:186-194 (1998).
9. Ewing B, Hillier L, Wendl MC, Green P: Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res 8:175-185 (1998).
10. Fries R, Durstewitz G: Digital DNA signatures for animal tagging. Nature Biotechnol 19:508 (2001).
11. Frönicke L, Wienberg J: Comparative chromosome painting defines the high rate of karyotype changes between pigs and bovids. Mammal Genome 12: 442-449 (2001).
12. Gordon D, Abajian C, Green P: Consed: a graphical tool for sequence finishing. Genome Res 8:195-202 (1998).
13. Grisart B, Coppieters W, Farnir F, Karim L, Ford C, Berzi P, Cambisano N, Mni M, Reid S, Simon P, Spelman R, Georges M, Snell R: Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Res 12:222-231 (2002).
14. ISCNDB (2000): International System for Chromosome Nomenclature of Domestic Bovids, Di Berardino D, Di Meo GP, Gallagher DS, Hayes H, Iannuzzi L (coordinator) (eds). Cytogenet Cell Genet 92:283-299 (2001).
15. Mayorek N, Grinstein I, Bar-Tana J: Triacylglycerol synthesis in cultured rat hepatocytes. The rate-limiting role of diacylglycerol acyltransferase. Eur J Biochem 182:395-400 (1989).
16. Meegalla RL, Billheimer JT, Cheng D: Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin. Biochem biophys Res Commun 298:317-323 (2002).
17. Nickerson DA, Tobe VO, Taylor SL: PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing. Nucl Acids Res 25:2745-2751 (1997).
18. Oelkers P, Behari A, Cromley D, Billheimer JT, Sturley SL: Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. J biol Chem 273:26765-26771 (1998).
19. Reeves A, Tear J: MicroMeasure for Windows, version 3.3. (Free program, distributed by the authors via http://www.colostate.edu/Depts/Biology/Micro- Measure, 2000).
20. Rozen S, Skaletsky HJ: Primer3. Code available at http://www-genome.wi. mit.edu/genome_software/ other/primer3.htm (1998).
21. Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV Jr: Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nature Genet 25:87-90 (2000).
22. Wain HM, Lush M, Ducluzeau F, Povey S: Genew: the Human Gene Nomenclature Database. Nucl Acids Res 30:169-171 (2002).
23. Warren W, Smith TP, Rexroad CE 3rd, Fahrenkrug SC, Allison T, Shu CL, Catanese J, de Jong PJ: Construction and characterization of a new bovine bacterial artificial chromosome library with 10 genome-equivalent coverage. Mammal Genome 11:662-663 (2000).
24. Winter A, Kramer W, Werner FA, Kollers S, Kata S, Durstewitz G, Buitkamp J, Womack JE, Thaller G, Fries R: Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content. Proc natl Acad Sci, USA 20:20 (2002).
25. Yen CL, Stone SJ, Cases S, Zhou P, Farese RV Jr: Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. Proc natl Acad Sci, USA 99:8512-8517 (2002).
26. Yen CL, Farese RV Jr: MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. J biol Chem 278:18532-18537 (2003).