Gains and optimal design in signaling pathways

Proceedings of the IEEE Conference on Decision and Control

Volumn 1, Issue , 2004, Pages 596-601

  Chaves, Madalena ^a,b   Sontag, Eduardo D ^a   Dinerstein, Robert J ^b  

^a RUTGERS UNIVERSITY   (United States)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRAL EQUATIONS; MATHEMATICAL OPERATORS; MATRIX ALGEBRA; SIGNALING; THEOREM PROVING; TRANSFER FUNCTIONS; VECTORS;

SIGNAL AMPLIFICATION; SIGNAL TRANSDUCTION; SIGNALING CASCADES; SIGNALING PATHWAYS;

LINEAR CONTROL SYSTEMS;

EID: 14344264702     PISSN: 07431546     EISSN: 25762370     Source Type: Conference Proceeding    
DOI: 10.1109/cdc.2004.1428697     Document Type: Conference Paper

References (12)

1. D. Angeli and E.D. Sontag, Monotone Control Systems, IEEE Trans. Autom. Control, 48(2003): 1684-1698.
2. A. R. Asthagiri and D.A. Lauffenburger, A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model, Biotechnology Progress, 17(2)(2001) 227-239.
3. U.S. Bhalla, P.T. Ram and R. Iyengar, MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network, Science 297(2002) 1018-1023.
4. F.J. Bruggeman, H.V. Westerhoff, J.B. Hoek and B.N. Kholodenko, Modular response analysis of cellular regulatory networks, J. Theor. Biol., 218(4)(2002) 507-520.
5. M. Chaves, E.D. Sontag and R.J. Dinerstein, Optimal length and signal amplification in weakly activated signal transduction cascades. J. Physical Chemistry B (2004) in press.
6. P. Cohen, Protein kinases - the major drug targets of the twenty-first century?, Nature Reviews Drug Discovery, 1(2002) 309-315.
7. M.L. Foster, F. Halley and J.E. Souness, Potential of p38 inhibitors in the treatment of rheumatoid arthritis Drug News & Perspectives, 13(8)(2000) 488-497.
8. R. Heinrich, B.G. Neel and T.A. Rapoport, Mathematical Models of Protein Kinase Signal Transduction, Molecular Cell, 9(2002) 957-970.
9. C-Y. F. Huang and J.E. Ferrell Jr., Untrasensitivity in the mitogen-activated protein kinase cascade, Proc. Natl. Acad. Sci. USA, 93(1996) 10078-10083.
10. P. Pouyssegur and P. Lenormand, Fidelity and spatio-temporal control in MAP kinase (ERKs) signaling, Eur. J. Biohem., 270(2003) 3291-3299.
11. nd edition), Springer, NY, 1998.
12. E.D. Sontag and M. Chaves, Computation of amplification for systems arising from cellular signaling pathways, submitted. Also available at http://arXiv.org/as q-bio.QM/0408012.