Reversal of the detrimental effects of chronic protein malnutrition on long bone fracture healing

Journal of Orthopaedic Trauma

Volumn 15, Issue 1, 2001, Pages 47-53

  Day, Susan M ^a   DeHeer, David H ^b  

^a Orthoped Associates of Grand Rapids   (United States)

^b CALVIN COLLEGE   (United States)

Author keywords

Animal model; Dietary intervention; Fracture healing; Protein malnutrition

Indexed keywords

ANIMAL; ARTICLE; CALLUS; CHRONIC DISEASE; COMPARATIVE STUDY; DIET; DISEASE MODEL; FEMALE; FEMUR FRACTURE; FRACTURE FIXATION; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN CALORIE MALNUTRITION; RANDOMIZATION; RAT; REFERENCE VALUE; RISK ASSESSMENT; SPRAGUE DAWLEY RAT;

ANIMALS; BONY CALLUS; CHRONIC DISEASE; DIET; DISEASE MODELS, ANIMAL; FEMALE; FEMORAL FRACTURES; FRACTURE FIXATION; PROTEIN-ENERGY MALNUTRITION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; RISK ASSESSMENT;

EID: 0035219306     PISSN: 08905339     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005131-200101000-00009     Document Type: Article

References (23)

1. Bak B, Andreassen TT. Reduced energy absorption of healed fracture in the rat. Acta Orthop Scand 1988;59:548-551.
2. Bonjour J, Schurch MA, Rizzoli R. Proteins and bone health. Pathol Biol 1997;45:57-59.
3. Brighton CT. Principles of fracture healing: part I: the biology of fracture repair. In: American Academy of Orthopaedic Surgeons Instructional Course Lectures XXXIII, ed by Murray JA. St Louis, MO, CV Mosby, 1984, pp 60-82.
4. Einhorn TA, Bonnarens F, Burstein AH. The contributions of dietary protein and mineral to the healing of experimental fractures. J Bone Joint Surg Am 1986;68:1389-1395.
5. Ekeland A, Engesaeter LB, Langeland N. Mechanical properties of fractured and intact rat femora evaluated by bending, torsional and tensile tests. Acta Orthop Scand 1981;52:605-613.
6. Engesaeter LB, Ekeland A, Langeland N. Methods for testing the mechanical properties of the rat femur. Acta Orthop Scand 1978;49:512-518.
7. Golden NH, Kreitzer P, Jacobson MS, et al. Disturbances in growth hormone secretion and action in adolescents with anorexia nervosa. J Pediatr 1994;125:655-660.
8. Goldring MB, Goldring SR. Skeletal response to cytokines. Clin Orthop 1990;258:245-278.
9. Guarniero R, De Barros Fo TEP, Tannuri U, et al. Study of fracture healing in protein malnutrition. Rev Paul Med 1992;110:63-68.
10. Heard CW, Griffith RB, Smith TK, et al. The effect of nutrition on fracture healing. Orthop Trans 1982;6:102.
11. Henderson CT. Nutrition. In: Geriatrics, 2nd ed, ed by Cassel CK. New York, Springer-Verlag, 1990.
12. Hessov H. Energy and protein intake in elderly patients in an orthopaedic surgical ward. Acta Chir Scand 1977;143:145-149.
13. Jensen JE, Jensen TG, Smith TK, et al. Nutrition in orthopaedic surgery. J Bone Joint Surg Am 1982;64:1263-1272.
14. Jha GJ, Ramalingaswami V. Bone growth in protein deficiency. Am J Pathol 1968;53:111-1123.
15. Long CL, Geiger JW, Richards EW, et al. Plasma amino acid concentrations in geriatric control and hip fracture patients. Am J Clin Nutr 1978;60B:150-162.
16. Macey LR, Kana SM, Jingushi S, et al. Defects of early fracture-healing in experimental diabetes. J Bone Joint Surg Am 1989;71: 720-733.
17. Patterson BM, Cornell CN, Carbone B, et al. Protein depletion and metabolic stress in elderly patients who have a fracture of the hip. J Bone Joint Surg Am 1992;74:152-160.
18. Pollak D, Roman Y, Simkin A, et al. The effect of protein malnutrition and nutritional support on the mechanical properties of fracture healing in the injured rat. J Parenter Enteral Nutr 1986;10:564-567.
19. Schurch MA, Rizzoli R, Slosman D, et al. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture: a randomized, double-blind, placebo-controlled trial Ann Intern Med 1998;128:801-809.
20. Shires R, Avioli LV, Bergfeld MA, et al. Effects of semistarvation on skeletal homeostasis. Endocrinology 1980;107:1530-1534.
21. Smith TK. Prevention of complications in orthopedic surgery sec-ondary to nutritional depletion. Clin Orthop 1987;222:91-97.
22. Sullivan DH, Carter WJ. Insulinlike growth factor I as an indicator of proteinenergy undemutrition among metabolically stable hospitalized elderly. J Am Coll Nutr 1994;13:184-191.
23. Tkatch L, Rapin CH, Rizzoli R, et al. Benefits of oral protein supplementation in elderly patients with fracture of the proximal femur. J Am Coll Nutr 1992;11:519-525.