Strategies to investigate circulating endothelial cells in cancer

Pathophysiology of Haemostasis and Thrombosis

Volumn 33, Issue 5-6, 2003, Pages 503-506

  Mancuso, Patrizia ^a   Rabascio, Cristina ^a   Bertolini, Francesco ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

Author keywords

Cancer; Circulating endothelial cells

Indexed keywords

CYCLOPHOSPHAMIDE; ENDOSTATIN; TUMOR MARKER;

ANGIOGENESIS; BOLUS INJECTION; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER RECURRENCE; CARCINOMA; CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL MOTILITY; CELL VIABILITY; CONFERENCE PAPER; CONTINUOUS INFUSION; CORRELATION ANALYSIS; DISEASE MARKER; DOSE RESPONSE; DRUG EFFECT; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; LYMPHOMA; MAXIMUM TOLERATED DOSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; TREATMENT OUTCOME; TUMOR GROWTH; TUMOR VOLUME;

ENDOTHELIAL CELLS; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC;

EID: 14044276223     PISSN: 14248832     EISSN: None     Source Type: Journal    
DOI: 10.1159/000083853     Document Type: Conference Paper

References (19)

1. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other diseases. Nat Med 1995;1:27-31.
2. Folkman J, Hahnfeldt P, Hlatky J. Cancer: looking outside the genome. Nat Rev Mol Cell Biol 2000;1:76-79.
3. Hlatky L, Hahnfeldt P, Folkman J. Clinical Application of Antiangiogenic Therapy: Microvessel Density, What it does and doesn't tell us. J Natl Cancer Inst 2002;94:883-893.
4. Weidner N. Angiogenesis as a predictor of clinical outcome in cancer patients. Hum. Pathol 2000;31:403-405.
5. Solovey A, Lin Y, Browne P, Choong S, Wayner E, Hebbel RP. Circulating endothelial cells in sickle cell anemia. New Engl J Med 1997;337:1584-1590.
6. Grefte A, Van der Giessen M, van Son W, The TH. Circulating cytomegalovirus-infected endothelial cells in patients with an active CMV infection. J Infect Dis 1993;167:270-277.
7. Drancourt M, George F, Brouqui P, Sampol J, Raoult D. Diagnosis of Mediterranean spotted fever by indirect immunofluorescence of Rickettsia conorii in circulating endothelial cells isolated with monoclonal antibody-coated immunomagnetic beads. J Infect Dis. 1992;166:660-663.
8. Mutin M, Canavy I, Blann A, Bory M, Sampol J, Dignat-George F. Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells. Blood 1999;93:2951-2958.
9. Lin Y, Weisdorf D.J, Solovey A, Hebbel RP. Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 2000;105:71-77.
10. George F, Poncelet P, Laurent J.C, Massot O, Arnoux D, Lequeux N, Ambrosi P, Chicheportiche C, Sampol J. Cytofluorometric detection of human endothelial cells in whole blood using S-Endo 1 monoclonal antibody. J Immunol Methods 1991;139:65-75.
11. Fusetti L, Gobbi A, Rabascio C, Pruneri G, Carboni N, Peccatori F, Martinelli G, Bertolini F. Human Myeloid and Lymphoid Malignancies in the Non-Obese Diabetic/Severe Combined Immunodeficiency Mouse Model: Frequency of Apoptotic Cells in Solid Tumors and Efficiency and Speed of Engraftment Correlate with Vascular Endothelial Growth Factor Production. Cancer Res 2000;60:2527-2534.
12. Bertolini F, Fusetti L, Mancuso P, Gobbi A, Corsini C, Ferrucci P.F, Martinelli G, Pruneri G. Endostatin, an antiangiogenic drug, induces tumor stabilization after chemotherapy or anti-CD20 therapy in a NOD/SCID mouse model of human high-grade non-Hodgkin's lymphoma. Blood 2000;96:282-287.
13. Philpott NJ, Turner AJC, Scopes J, Westby M, Marsch JCW, Gordon-Smith EC, Dalgleish AG, Gibson FM. The use of 7-amino actinomycin D in identifying apoptosis: Semplicity of use and broad spectrum of application compared with other techniques. Blood 1996;87:2244-2251.
14. Monestiroli S, Mancuso P, Burlini A, Pruneri G, Dell'Agnola C, Gobbi A, Martinelli G, Bertolini F. Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma. Cancer Res 2001;61:4341-4344.
15. Capillo M, Mancuso P, Gobbi A, Monestiroli S, Pruneri G, Dell'Agnola C, Martinelli G, Shultz L, Bertolini F. Continuous infusion of endostatin inhibits differentiation, mobilization and clonogenic potential of endothelial cell progenitors. Clin Cancer Res 2003;9:377-382.
16. Bertolini F, Paul S, Mancuso P, Monestiroli S, Gobbi A, Shaked Y, Kerbel RS. Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells. Cancer Res 2003;63:4342-4346.
17. Mancuso P, Burlini A, Pruneri G, Goldhirsch A, Martinelli G, Bertolini F. Resting and activated endothelial cells are increased in the peripheral blood of cancer patients. Blood 2001;97:3658-3661.
18. Rafii S. Circulating endothelial precursors: mystery, reality, and promise. J Clin Invest 2000;105:17-19.
19. Rabascio C, Muratori E, Mancuso P, Calleri A, Raia V, Fouts T, Cinieri S, Veronesi G, Pruneri G, Lampertico P, Iavarone M, Martinelli G, Goldhirsch A, Bertolini F. Assessing tumor angiogenesis: Increased circulating VE-cadherin RNA in patients with cancer indicates viability of circulating endothelial cells. Cancer Res 2004; in press.