Permanent motor activity and learning disorders induced by exposure to phenytoin during gestation and early infancy in the rat

Neurotoxicology and Teratology

Volumn 27, Issue 2, 2005, Pages 299-310

  Wolansky, Marcelo Javier ^a,c   Azcurra, Julio Marcos ^a,b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Neurobehavioral Toxicology Branch ^*  (Argentina)

^c Neurotoxicology Division   (United States)

Author keywords

Behavioral teratology; Infancy; Phenytoin

Indexed keywords

PHENYTOIN; SODIUM CHLORIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR TERATOLOGY; CIRCLING BEHAVIOR; CONTROLLED STUDY; FEMALE; GESTATION PERIOD; GESTATIONAL AGE; LEARNING DISORDER; MOTOR ACTIVITY; NEUROTOXICITY; NONHUMAN; PERINATAL DRUG EXPOSURE; POSTNATAL GROWTH; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROGENY; RAT; REINFORCEMENT; REWARD;

EID: 14044267014     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ntt.2004.12.006     Document Type: Article

References (58)

1. J. Adams, C.V. Vorhees, and L.D. Middaugh Developmental neurotoxicity of anticonvulsants: human and animal evidence on phenytoin Neurotoxicol. Teratol. 12 3 1990 203 214
2. R. Appleton, T. Martland, and B. Phillips Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children Cochrane Database Syst. Rev. 4 2002 CD001095
3. P. Bittigau, M. Sirfringer, and C. Ikonomidou Antiepileptic drugs and apoptosis in the developing brain Ann. N.Y. Acad. Sci. 993 2003 103 114
4. B.F.D. Bourgeois Pharmacologic intervention and treatment of childhood seizure disorders: relative efficacy and safety of antiepileptic drugs Epilepsia 35 Suppl. 2 1994 S18 S23
5. J.L. Brusés, and J.M. Azcurra The Circling Training: a behavioral paradigm for functional teratology testing P.M. Conn Paradigms for the study of behavior Meth. Neurosci. vol. 14 1993 Acad. Press New York 166 179
6. J.L. Brusés, P.M. Berninsone, S. Ojea, and J.M. Azcurra The circling training rat model as a behavioral teratology test Pharmacol. Biochem. Behav. 38 1991 739 745
7. M. Buck Phenytoin: optimizing therapy in children Pediatr. Pharmacother. 2 8 1996 1 7 (http://www.people.virginia.edu/~smb4v/pedpharm/v2n8)
8. J. Burguer, and M. Gochfeld Lead and neurobehavioral development in gulls: a model for understanding effects in the laboratory and the field Neurotoxicology 18 2 1997 495 506
9. H.M. Carman, R.M. Booze, and C.F. Mactutus Long-term retention of spatial navigation by preweanling rats Dev. Psychobiol. 40 1 2002 68 77
10. J.C. Dean, H. Hailey, S.J. Moore, D.J. Lloyd, P.D. Turnpenny, and J. Little Long-term health and neurodevelopment in children exposed to antiepileptic drugs before birth J. Med. Genet. 39 4 2002 251 259
11. W.E. Dodson Aspects of antiepileptic treatment in children Epilepsia 29 Suppl. 3 1988 S10 S14
12. M.M.A. Elmazar, and F.M. Sullivan Effect of prenatal phenytoin administration on postnatal development of the rat: a behavioral teratology study Teratology 24 1981 115 124
13. E.M. Faustman, and G.S. Oinenn Risk assessment C.D. Klassen Casarett and Doull's toxicology, the basic science of poisons Sixth edition 2001 McGraw-Hill NewYork 93 94
14. T. Fujii, H. Ikeda, and N. Yamamoto Prenatal exposure of rats to phenytoin develops supersensitivity to haloperidol in adulthood Proc. Jpn. Acad., Ser. B Phys. Biol. Sci. 58 3 1982 78 82
15. D.W. Gallager, and P. Mallorga Diphenylhydantoin: pre- and postnatal administration alters diazepam binding in developing rat cerebral cortex Science 208 4439 1980 64 66
16. J.W. Hanson, N.C. Myrianthopoulos, M.A.S. Harvey, and D.W. Smith Risks to the offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndrome J. Pediatr. 89 1976 662 668
17. R.J. Harvey Cerebellar regulation in movement control TINS 3 1980 281 284
18. W.A. Hauser Status epilepticus: frequency, etiology and neurological sequelae Adv. Neurol. 34 1983 3 14
19. N. Herschkowitz, J. Kagan, and K. Zilles Neurobiological bases of development in the second year Neuropediatrics 30 5 1999 221 230
20. C.D. Herzog, R.W. Stackman, and T.J. Walsh Intraseptal flumazenil enhances, while diazepam binding inhibitor impairs, performance in a working memory task Neurobiol. Learn. Mem. 66 3 1996 341 352
21. G.M. Heyman, and B. Beer A new approach for evaluating the behavioral effects of antipsychotic drugs TIPS 8 1987 388 393
22. G.R. Ibarra, G.C. Paratcha, M.J. Wolansky, and J.M. Azcurra Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training Neuroreport 7 15-17 1996 2491 2494
23. S. Kaneko, and T. Kondo Antiepileptic agents and birth defects: incidence, mechanisms and prevention CNS Drugs 3 1995 41 45
24. L. Kokkinidis, and H. Anisman Perseveration and rotational behavior elicited by d-amphetamine in a Y-maze exploratory task: differential effects of intraperitoneal and unilateral intraventricular administration Psychopharmacology 52 1977 123 128
25. A. Latham, and D.H. Paul Combined study of the pattern of spontaneous activity of cerebellar Purkinje cells and phenytoin serum levels in the rat Epilepsia 21 1980 597 610
26. G. Laviola Mouse models of emotional postpartum disorders Ann. Ist. Super. Sanita 29 1 1993 153 162
27. G. Laviola, G. Renna, G. Bignami, and V. Cuomo Ontogenetic and pharmacological dissociation of various components of locomotor activity and habituation in the rat Int. J. Dev. Neurosci. 6 5 1988 431 438
28. T.W. Massinagle, and S. Buttross Survey of treatment practices for neonatal seizures J. Perinatol. 13 2 1993 107 110
29. M.A. McCartney, P.L. Cinto, S.-S. Wang, and S. Altan Developmental effects of phenytoin may differ depending on sex of offspring Neurotoxicol. Teratol. 21 2 1999 119 128
30. J.O. McNamara Drugs effective in the therapy of the epilepsies J.G. Hardman L.E. Limbird A. Goodman Gilman Goodman and Gilman's the pharmacological basis of therapeutics 2001 McGraw-Hill, Co. New York 521 547 Chaper 21
31. J. Maschover Reinisch, S.A. Sanders, E.L. Mortensen, and D.B. Rubin In utero exposure to phenobarbital and intelligence deficits in adult men JAMA 274 19 1995 1518 1525
32. M. Molinari, L. Petrosini, and L.G. Grammaldo Spatial event processing Int. Rev. Neurobiol. 41 1997 217 230
33. H. Ogura, M. Yasuda, S. Nakamura, H. Yamashita, K. Mikoshiba, and H. Ohmori Neurotoxic damage of granule cells in the dentate gyrus and the cerebellum and cognitive deficit following neonatal administration of phenytoin in mice J. Neuropathol. Exp. Neurol. 61 11 2002 956 967
34. C.E. Pfeifle, D.S. Adler, and W.L. Gannaway Phenytoin sodium solubility in three intravenous solutions Am. J. Hosp. Pharm. 38 3 1981 358 362
35. N.K. Phillips, and J.S. Lockard Infant monkey hyperexcitability after prenatal exposure to antiepileptic compounds Epilepsia (USA) 37 10 1996 991 999
36. W.J. Pizzi, and R.M. Jersey Effects of prenatal diphenylhydantoin treatment on reproductive outcome, development, and behavior in rats Neurotoxicol. Teratol. 14 2 1992 111 117
37. H. Rantala, W. Donald Shields, P.D. Christenson, C. Nielsen, D. Buch, V. Jacobsen, B. Zachau-Christiansen, M. Uhari, and J.D. Cherry Risk factors of infantile spasms compared with other seizures in children under 2 years of age Epilepsia 37 4 1996 362 366
38. D. Rice, and S. Barone Jr. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models Environ. Health Perspect. 108 Suppl. 3 2000 511 533
39. M.A. Schilling, S.L. Inman, L.L. Morford, M.S. Moran, and C.V. Vorhees Prenatal phenytoin exposure and spatial navigation in offspring: effects on reference and working memory and on discrimination learning Neurotoxicol. Teratol. 21 5 1999 567 578
40. L.P. Spear, and S.E. File Methodological considerations in neurobehavioral teratology Pharmacol. Biochem. Behav. 55 4 1996 455 477
41. J.M. Spyker Assessing the impact of low level chemicals on development: behavioral and latent effects Fed. Proc. 34 9 1975 1835 1844
42. D.F. Swaab, and M. Mirmiran The influence of chemicals and environment on brain development: "behavioral teratology" Prog. Clin. Biol. Res. 163B 1985 447 451
43. T. Tachibana, T. Yoshiki, K. Fukunishi, and T. Tanimura Estimated magnitude of behavioral effects of phenytoin in rats and its reproducibility: a collaborative behavioral teratology study in Japan Physiol. Behav. 60 3 1996 941 952
44. B. Tonnby, H.L. Nilsson, A.P. Aldenkamp, W.C.J. Alpherts, G. Blennow, D. Elmqvist, J. Heijbel, P. Sandstedt, L. Wåhlander, and E. Wosse Withdrawal of antiepileptic medication in children. Correlation of cognitive function and plasma concentration: the multicentre "Holmfrid" study Epilepsy Res. 19 1994 141 152
45. S. Tsutsumi, M. Akaike, H. Ohno, and N. Kato Learning/memory impairment in rat offspring prenatally exposed to phenytoin Neuroteratol. Toxicol. 20 2 1998 123 132
46. D. Vanoverloop, R.R. Schnell, E.A. Harvey, and L.B. Holmes The effects of prenatal exposure to phenytoin and other anticonvulsants on intellectual function at 4 to 8 years of age Neurotoxicol. Teratol. 14 5 1992 329 335
47. A. Vernadakis, and D.M. Woodbury The developing animal as a model Epilepsia 10 2 1969 163 178
48. C.V. Vorhees Developmental neurotoxicity induced by therapeutic and illicit drugs Environ. Health Perspect. 102 Suppl. 2 1994 145 153
49. C.V. Vorhees Fetal anticonvulsant exposure: effects on behavioral and physical development H.M. Wisniewski D.A. Snider Mental retardation: research, education and technology transfer Annals of the New York Academy of Sciences vol. 477 1986 49 62
50. C.V. Vorhees, and E. Molinow Behavioral teratogenesis: long-term influences on behavior from early exposure to environmental agents J.D. Osofsky Handbook of infant development Second edition 1987 Wiley New York 913 971
51. C.V. Vorhees, J.M. Rindler, and D.R. Minck Effects of exposure period and nutrition on the developmental neurotoxicity of anticonvulsants in rats: short and long-term effects Neurotoxicology 11 2 1990 273 283
52. K.D. Weber, W.A. Fletcher, C.R. Gordon, G. Melvill Jones, and E.W. Block Motor learning in the "podokinetic" system and its role in spatial orientation during locomotion Exp. Brain Res. 120 1998 377 385
53. W.P. Weisenburger, D.R. Minck, K.D. Acuff, and C.V. Vorhees Dose-response effects of prenatal phenytoin exposure in rats: effects on early locomotion, maze learning, and memory as a function of phenytoin-induced circling behavior Neurotoxicol. Teratol. 12 2 1990 145 152
54. K. Wide, E. Henning, T. Tomson, and B. Windladh Psychomotor development in preschool children exposed to antiepileptic drugs in utero Acta Paediatr. 91 4 2002 409 414
55. M.J. Wolansky, L. Mongiat, G.R. Ibarra, G.C. Paratcha, R.J. Cabrera, and J.M. Azcurra Reduction of sample size per experimental group and time per agent examined in a sensitive rat model for behavioral teratology screening routines Third World Congress on Alternatives and Animal Use in the Life Sciences, Bologna, Italy, 29th August-2nd September 1999 Alternatives to Laboratory Animals (ATLA) 165A Suppl.
56. M.J. Wolansky, M. Soiza-Reilly, M. Fossati, and J.M. Azcurra Postnatal haloperidol eliminates the deficit in circling behavior produced by prenatal exposure to the same drug Neurotoxicol. Teratol. 26 4 2004 561 569
57. R.S. Woodworth, H. Schlosberg, J.W. Kling, and L.A. Riggs J.W. Kling L.A. Riggs Woodworth and Schlosberg's experimental psychology Third edition 1971 Holt, Rinehart and Winston, Inc. New York
58. M.S. Yerby, and S. Collins Pregnancy and the mother. Chapter 192, 2027-2035 J. Engel Jr. T. Pedley Epilepsy: a comprehensive textbook 1997 Lippincott Raven Publishers