In vitro and in vivo evaluation of the metabolism and pharmacokinetics of sebacoyl dinalbuphine

Drug Metabolism and Disposition

Volumn 33, Issue 3, 2005, Pages 395-402

  Pao, Li Heng ^a   Hsiong, Cheng Huei ^a   Hu, Oliver Yoa Pu ^a   Wang, Jhi Jung ^c   Ho, Shung Tai ^b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c CHI MEI MEDICAL CENTER   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE DERIVATIVE; NALBUPHINE; PRODRUG; SEBACOYL DINALBUPHINE; SESAME SEED OIL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD; COMPARATIVE STUDY; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DESIGN; DRUG DISPOSITION; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG PENETRATION; DRUG RELEASE; ERYTHROCYTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; MALE; NONHUMAN; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; RABBIT; RAT;

ANALGESICS, OPIOID; ANIMALS; AREA UNDER CURVE; DOGS; ERYTHROCYTES; HUMANS; HYDROLYSIS; MALE; NALBUPHINE; NARCOTIC ANTAGONISTS; PLASMA; PRODRUGS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SESAME OIL; SPECIES SPECIFICITY;

EID: 14044259322     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.002451     Document Type: Article

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