Up-regulation of interleukin-8, interleukin-10, monocyte chemotactic protein-1, and monocyte chemotactic protein-3 in peripheral blood monocytes in stable lung transplant recipients: Are immunosuppression regimens working?

Transplantation

Volumn 79, Issue 4, 2005, Pages 387-391

  Hodge, Greg ^a,b   Hodge, Sandra ^a   Reynolds, Paul N ^a   Holmes, Mark ^a  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b WOMEN S AND CHILDREN S HOSPITAL   (Australia)

Author keywords

Flow cytometry; Immunosuppression; Intracellular cytokines chemokines; Lung transplant; MCP 3; Monocytes

Indexed keywords

AZATHIOPRINE; CHEMOKINE; CYCLOSPORIN A; CYTOKINE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; PREDNISONE; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; LEUKOCYTE; LUNG TRANSPLANTATION; MONOCYTE; PRIORITY JOURNAL; UPREGULATION;

ADULT; CHEMOKINE CCL2; CYTOKINES; HUMANS; IMMUNOSUPPRESSION; INTERLEUKIN-10; INTERLEUKIN-8; LUNG TRANSPLANTATION; MIDDLE AGED; MONOCYTE CHEMOATTRACTANT PROTEINS; MONOCYTES; UP-REGULATION;

EID: 14044256567     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000151631.66884.2E     Document Type: Article

References (23)

1. Sundaresan S, Alevy YG, Steward N, et al. Cytokine gene transcripts for tumor necrosis factor-alpha, interleukin-2, and interferon-gamma in human pulmonary allografts. J Heart Lung Transplant 1995; 14: 512.
2. Sekine Y, Yasufuku K, Heidler KM, et al. Monocyte chemotactic protein-1 and RANTES are chemotactic for graft infiltrating lymphocytes during acute allograft rejection. Am J Respir Cell Mol Biol 2000; 23: 719.
3. Huang DR, Wang J, Kivisakk P, et al. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J Exp Med 2001; 19: 713.
4. Wain JH, Kirby JA, Ali S. Leucocyte chemotaxis: examination of mitogen-activated protein kinase and phosphoinositide 3-kinase activation by monocyte chemoattractant proteins-1, -2, -3 and -4. Clin Exp Immunol 2002; 127: 436.
5. Taub DD, Proost P, Murphy WJ, et al. Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes. J Clin Invest 1995; 95: 1370.
6. Reynaud-Gaubert M, Marvin V, Thirion X, et al. Upregulation of chemokines in bronchiolar lavage fluid as a predictor of post-transplant airway obliteration. J Heart Lung Transplant 2002; 21: 721.
7. Belperio JA, Keane MP, Burdick MD, et al. Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. J Clin Invest 2001; 108: 547.
8. Franci C, Wong LM, van Damme J, et al. Monocyte chemotactic protein-3, but not monocyte chemotactic protein-2 is a functional ligand of the monocyte chemoattractant protein-1 receptor. J Immunol 1995; 154: 6511.
9. Yoshida Y, Iwaki Y, Pham S, et al. Benefits of posttransplantation monitoring of interleukin 6 in lung transplantation. Ann Thorac Surg 1993; 55: 89.
10. Jordan SC, Kondo T, Prehn J, et al. Cytokine gene activation in rat lung allografts: analysis by Northern blotting. Transplant Proc 1991; 23: 604.
11. Hodge G, Flower R, Han P. Australian plasma-derived factor VIII concentrate inhibits Th1 type cytokines but increases Th2 type cytokine, IL-10. Br J Haematol 2000; 109: 902.
12. Hodge G, Han P. Factor VIII concentrate inhibits T-helper-type 2 (Th2) cytokine production in vitro: relevance to inhibitor antibody formation. Haemophilia 2001; 7: 490.
13. Ong VH, Evans LA, Shiwen X, et al. Monocyte chemoattractant protein 3 as a mediator of fibrosis: overexpression in systemic sclerosis and the type 1 tight-skin mouse. Arthritis Rheum 2003; 48: 1979.
14. Boehler A. The role of interleukin-10 in lung transplantation. Transpl Immunol 2002; 9: 121.
15. Romagnani S. The Th1/Th2 paradigm. Immunol Today 1997; 18: 263.
16. Gonnella PA, Kondali D, Weiner HL. Induction of low dose tolerance in monocyte chemotactic protein-1 and CCR2 deficient mice. J Immunol 2003; 170: 2316.
17. Rose CE, Sund SS, Fu SM. Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lung. Microcirculation 2003; 10: 273.
18. Hodge S, Hodge G, Flower R, et al. Methyl prednisolone upregulates monocyte IL-10 production in stimulated whole blood. Scand J Immunol 1999; 49: 548.
19. Hodge G, Hodge S, Han P. Allium sativum (garlic) suppresses leucocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry 2002; 48: 209.
20. Tsiavou A, Degiannis D, Hatzigelaki E, et al. Flow cytometric detection of intracellular IL-12 release: in vitro effect of widely used immunosuppressants. Int Pharmacol 2002; 12: 1713.
21. Kitayama T, Hayamizu K, Egi H, et al. Facilitation of tacrolimus-induced heart-allograft acceptability by pretransplant host treatment with granulocyte colony-stimulating factor: interleukin-12-restricted suppression of intragraft monokine mRNA expression. Transplantation 2003; 75: 553.
22. Brach MA, Gruss HJ, Riedel D, et al. Effect of antiinflammatory agents on synthesis of MCP-1/JE transcripts by human blood monocytes. Mol Pharmacol 1992; 42: 63.
23. Wong PK, Cuello C, Bertouch JV, et al. Effects of pulse methylprednisolone on macrophage chemotactic protein-1 and macrophage inflammatory protein-1alpha in rheumatoid synovium. J Rheumatol 2001; 28: 2634.