GABAergic neurons in the central region of the spinal cord: A novel substrate for sympathetic inhibition

Journal of Neuroscience

Volumn 25, Issue 5, 2005, Pages 1063-1070

  Deuchars, Susan A ^a   Milligan, Carol J ^a   Stornetta, Ruth L ^b   Deuchars, Jim ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Bicuculline; Cardiovascular; Electrophysiology; in situ hybridization; Interneuron; Sympathetic preganglionic

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; BICUCULLINE; CHLORIDE; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 67; MESSENGER RNA;

ADRENAL GLAND; ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ELECTROSTIMULATION; HOMEOSTASIS; HYPERPOLARIZATION; IN SITU HYBRIDIZATION; INHIBITORY POSTSYNAPTIC POTENTIAL; INTERNEURON; MALE; MONOSYNAPTIC POTENTIAL; NERVE CELL; NONHUMAN; PREGANGLIONIC NERVE CELL; PRIORITY JOURNAL; PSEUDORABIES HERPETOVIRUS; RAT; SPINAL CORD; SYMPATHETIC BLOCKING; SYNAPTIC INHIBITION;

2-AMINO-5-PHOSPHONOVALERATE; ACTION POTENTIALS; ANIMALS; AUTONOMIC FIBERS, PREGANGLIONIC; AXONAL TRANSPORT; BICUCULLINE; CHLORIDES; ELECTRIC STIMULATION; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; GLUTAMIC ACID; HERPESVIRUS 1, SUID; HOMEOSTASIS; IN SITU HYBRIDIZATION; INTERNEURONS; ISOENZYMES; KYNURENIC ACID; MALE; PATCH-CLAMP TECHNIQUES; QUINOXALINES; RATS; RATS, WISTAR; RNA, MESSENGER; SPINAL CORD; STRYCHNINE;

EID: 13944284457     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3740-04.2005     Document Type: Article

References (35)

1. Anderson CR, McLachlan EM, Srb-Christie O (1989) Distribution of sympathetic preganglionic neurons and monoaminergic nerve terminals in the spinal cord of the rat. J Comp Neurol 283:269-284.
2. Bacon SJ, Smith AD (1993) A monosynaptic pathway from an identified vasomotor centre in the medial prefrontal cortex to an autonomic area in the thoracic spinal cord. Neuroscience 54:719-728.
3. Brooke RE, Deuchars J, Deuchars SA (2004) Input-specific modulation of neurotransmitter release in the lateral horn of the spinal cord via adenosine receptors. J Neurosci 24:127-137.
4. Cabot JB (1990) Sympathetic preganglionic neurons: cytoarchitecture, ultrastructure, and biophysical properties. In: Central regulation of autonomie functions (Loewy AD, Spyer KM, eds), pp 22-34. New York: Oxford UP.
5. Cabot JB, Alessi V, Carroll J, Ligorio M (1994) Spinal cord lamina V and lamina VII interneuronal projections to sympathetic preganglionic neurons. J Comp Neurol 347:515-530.
6. Caverson MM, Ciriello J, Calaresu FR (1983) Cardiovascular afferent inputs to neurons in the ventrolateral medulla projecting directly to the central autonomic area of the thoracic cord in the cat. Brain Res 274:354-358.
7. Clarke HA, Dekaban GA, Weaver LC (1998) Identification of lamina V and VII interneurons presynaptic to adrenal sympathetic preganglionic neurons in rats using a recombinant herpes simplex virus type 1. Neuroscience 85:863-872.
8. Deuchars SA, Spyer KM, Gilbey MP (1997) Stimulation within the rostral ventrolateral medulla can evoke monosynaptic GABAergic IPSPs in sympathetic preganglionic neurons in vitro. J Neurophysiol 77:229-235.
9. Deuchars SA, Brooke RE, Deuchars J (2001a) Adenosine A1 receptors reduce release from excitatory but not inhibitory synaptic inputs onto lateral horn neurons. J Neurosci 21:6308-6320.
10. Deuchars SA, Brooke RE, Frater B, Deuchars J (2001b) Properties of interneurones in the intermediolateral cell column of the rat spinal cord: role of the potassium channel subunit Kv3.1. Neuroscience 106:433-446.
11. Dun NJ, Mo N (1989) Inhibitory postsynaptic potentials in neonatal rat sympathetic preganglionic neurones in vitro. J Physiol (Lond) 410:267-281.
12. Esclapez M, Tillakaratne NJ, Tobin AJ, Houser CR (1993) Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods. J Comp Neurol 331:339-362.
13. Gaynor RB, Feldman LT, Berk AJ (1985) Transcription of class III genes activated by viral immediate early proteins. Science 230:447-450.
14. Gilbey MP, Spyer KM (1993) Essential organization of the sympathetic nervous system. Baillieres Clin Endocrinol Metab 7:259-278.
15. Joshi S, Levatte MA, Dekaban GA, Weaver LC (1995) Identification of spinal interneurons antecedent to adrenal sympathetic preganglionic neurons using trans-synaptic transport of herpes simplex virus type 1. Neuroscience 65:893-903.
16. Krupp J, Feltz P (1993) Synaptic- and agonist-induced chloride currents in neonatal rat sympathetic preganglionic neurones in vitro. J Physiol (Lond) 471:729-748.
17. Krupp J, Larmet Y, Feltz P (1994) Postnatal change of glydnergic IPSC decay in sympathetic preganglionic neurons. NeuroReport 5:2437-2440.
18. Krupp J, Bordey A, Feltz P (1997) Electrophysiological evidence for multiple glycinergic inputs to neonatal rat sympathetic preganglionic neurons in vitro. Eur J Neurosci 9:1711-1719.
19. Llewellyn-Smith IJ (2002) GABA in the control of sympathetic preganglionic neurons. Clin Exp Pharmacol Physiol 29:507-513.
20. Logan SD, Pickering AE, Gibson IC, Nolan MF, Spanswick D (1996) Electrotonic coupling between rat sympathetic preganglionic neurones in vitro. J Physiol (Lond) 495:491-502.
21. McCall RB, Gebber GL, Barman SM (1977) Spinal interneurons in the baroreceptor reflex arc. Am J Physiol 232:H657-H665.
22. Nolan MF, Logan SD, Spanswick D (1999) Electrophysiological properties of electrical synapses between rat sympathetic preganglionic neurones in vitro. J Physiol (Lond) 519:753-764.
23. Oroskar AA, Read GS (1989) Control of mRNA stability by the virion host shutoff function of herpes simplex virus. J Virol 63:1897-1906.
24. Ottem EN, Godwin JG, Krishnan S, Petersen SL (2004) Dual-phenotype GABA/glutamate neurons in adult preoptic area: sexual dimorphism and function. J Neurosci 24:8097-8105.
25. Pyner S, Coote JH (1998) Rostroventrolateral medulla neurons preferentially project to target-specified sympathetic preganglionic neurons. Neuroscience 83:617-631.
26. Ranson RN, Motawei K, Pyner S, Coote JH (1998) The paraventricular nucleus of the hypothalamus sends efferents to the spinal cord of the rat that closely appose sympathetic preganglionic neurones projecting to the stellate ganglion. Exp Brain Res 120:164-172.
27. Spanswick D, Pickering AE, Gibson IC, Logan SD (1994) Inhibition of sympathetic preganglionic neurons by spinal glycinergic interneurons. Neuroscience 62:205-216.
28. Stornetta RL, Guyenet PG (1999) Distribution of glutamic acid decarboxylase mRNA-containing neurons in rat medulla projecting to thoracic spinal cord in relation to monoaminergic brainstem neurons. J Comp Neurol 407:367-380.
29. Stornetta RL, McQuiston TJ, Guyenet PG (2004) GABAergic and glycinergic presympathetic neurons of rat medulla oblongata identified by retrograde transport of pseudorabies virus and in situ hybridization. J Comp Neurol 479:257-270.
30. Strack AM, Sawyer WB, Marubio LM, Loewy AD (1988) Spinal origin of sympathetic preganglionic neurons in the rat. Brain Res 455:187-191.
31. Strack AM, Sawyer WB, Platt KB, Loewy AD (1989) CNS cell groups regulating the sympathetic outflow to adrenal gland as revealed by transneuronal cell body labeling with pseudorabies virus. Brain Res 491:274-296.
32. Tang X, Neckel ND, Schramm LP (2004) Spinal interneurons infected by renal injection of pseudorabies virus in the rat. Brain Res 1004:1-7.
33. Westerhaus MJ, Loewy AD (1999) Sympathetic-related neurons in the preoptic region of the rat identified by viral transneuronal labeling. J Comp Neurol 414:361-378.
34. Wuenschell CW, Fisher RS, Kaufman DL, Tobin AJ (1986) In situ hybridization to localize mRNA encoding the neurotransmitter synthetic enzyme glutamate decarboxylase in mouse cerebellum. Proc Natl Acad Sci USA 83:6193-6197.
35. Zagon A, Smith AD (1993) Monosynaptic projections from the rostral ventrolateral medulla oblongata to identified sympathetic preganglionic neurons. Neuroscience 54:729-743.