Estrogen treatment for urinary incontinence: Never, now, or in the future?

JAMA

Volumn 293, Issue 8, 2005, Pages 998-1001

  DuBeau, Catherine E ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONJUGATED ESTROGEN; ESTROGEN; GESTAGEN; MEDROXYPROGESTERONE ACETATE; PLACEBO;

CLINICAL TRIAL; DAILY LIFE ACTIVITY; EDITORIAL; ESTROGEN THERAPY; HUMAN; OBESITY; POSTMENOPAUSE; PRIORITY JOURNAL; QUALITY OF LIFE; URINE INCONTINENCE; VAGINA BLEEDING; FEMALE; NOTE;

ESTROGEN REPLACEMENT THERAPY; ESTROGENS, CONJUGATED (USP); FEMALE; HUMANS; MEDROXYPROGESTERONE 17-ACETATE; URINARY INCONTINENCE;

EID: 13944269937     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.293.8.998     Document Type: Editorial

References (30)

1. Moehrer B, Hextall A, Jackson S. Oestrogens for urinary incontinence in women [abstract]. Cochrane Database Syst Rev, Available at: http://www.update- software.com/abstracts/ab001405.htm. Accessed January 21, 2005.
2. Andersson K-E, Appell R, Cardozo L, et al. Pharmacological treatment of urinary incontinence. In: Abrams PC, Khoury S, Wein A, eds. Incontinence: 3rd International Consultation on Incontinence. Plymouth, England: Health Publication Ltd; In press.
3. Grady D, Brown J, Vittinghoff E, et al. Postmenopausal hormones and incontinence: the Heart and Estrogen/Progestin Replacement Study. Obstet Gynecol. 2001;97:116-120.
4. Hendrix SL, Cochrane BB, Nygaard IE, et al. Effects of estrogen with and without progestin on urinary incontinence. JAMA. 2005;293:935-948.
5. Brown J, Nyberg L, Kusek J, et al. Proceedings of the National Institute of Diabetes and Digestive and Kidney Diseases International Symposium on epidemiologic issues in urinary incontinence in women. Am J Obstet Gynecol. 2003;188:S77-S88.
6. Abrams P, Cardozo L, Fall M, et al. The standardisation of terminology in lower urinary tract function. Neurourol Urodyn. 2002;21:167-178.
7. Hunskaar S, Burgio K, Diokno AC, Herzog AR, Hjalmas K, Lapitan MC. Epidemiology and natural history of urinary incontinence. In: Abrams PC, Khoury S, Wein A, eds. Incontinence: 2nd International Consultation on Incontinence. Plymouth, England: Health Publication Ltd; 2002:165-201.
8. McDonough P. The randomized world is not without its imperfections: reflections on the Women's Health Initiative. Fertil Steril. 2002;78:951-956.
9. Women's Health Initiative Steering Committee. Effects of cronjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA. 2004;291:1701-1712.
10. DuBeau C, Khullar V, Versi E. "Unblinding" in randomized controlled drug trial for urinary incontinence: implications for assessing outcomes when adverse effects are evident. Neurourol Urodyn. 2005;24:13-20.
11. Branch L, Walker L, Wetle T, DuBeau C, Resnick N. Urinary incontinence knowledge among community-dwelling people 65 years of age and older. J Am Geriatr Soc. 1994;42:1257-1262.
12. Mattiasson A, Djurhuus JC, Fonda D, Lose G, Nordling J, Støhrer M. Standardisation of outcome studies in patients with lower urinary tract dysfunction: a report on general principles from the Standardisation Committee of the International Continence Society. Neurourol Urodyn. 1998;17:249-253.
13. DuBeau C, Keily DK, Resnick NM. Quality of life impact of urge incontinence in older persons: a new measure and conceptual structure. J Am Geriatr Soc. 1999; 47:989-994.
14. Hays J, Ockene J, Brunner R, et al; WHI Investigators. Effects of estrogen plus progestin on health-related quality of life. N Engl J Med 2003;348:1839-1854.
15. Stenberg Å, Heimer G, Ulmsten U. The prevalence of urogenital symptoms in postmenopausal women. Maturitas. 1995;22:S17-S20.
16. Forsberg J-G. A morphologist's approach to the vagina: age-related changes and estrogen sensitivity. Maturitas. 1995;22:S7-S15.
17. Vereist M, Maltau J, Ørbo A. Computerised morphometric study of the paraurethral tissue in young and elderly women. Neurourol Urodyn. 2002;21:529-533.
18. Carlile A, Davies I, Rigby A, Brocklehurst J. Age changes in the human female urethra: a morphometric study. J Urol. 1988;139:532-535.
19. DeLancey J, Gosling J, Creed K, et al. Gross anatomy and cell biology of the lower urinary tract. In: Abrams PC, Khoury S, Wein A, eds. Incontinence: 2nd International Consultation on Incontinence. Plymouth, England: Health Publication Ltd; 2002:19-82.
20. Andersson K-E, Amer A. Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev. 2004;84:935-986.
21. Zhu Q, Ritchie J, Marouf N, et al. Role of ovarian hormones in the pathogenesis of impaired detrusor contractility: evidence in ovariectomized rodents. J Urol. 2001;166:1136-1141.
22. Zhu Q, Resnick N, Elbadawi A, Kuchel G. Estrogen and postnatal maturation increase caveolar number and caveolin-1 protein in bladder smooth muscle cells. J Urol. 2004;171:467-471.
23. Jackson S, James M, Abrams P. The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence. BJOG. 2002;109:339-344.
24. Keane D, Sims T, Abrams P, Bailey A. Analysis of collagen status in premenopausal nulliparous females with genuine stress incontinence. Br J Obstet Gynaecol. 1997;104:994-998.
25. Kuchel G, Tannenbaum C, Greenspan S, Resnick N. Can variability in the hormonal status of elderly women assist in the decision to administer estrogen? J Womens Health Gender Based Med. 2001;10:109-116.
26. Rossouw JE, Anderson GL, Prentice RL, et al; Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA. 2002;288:321-333.
27. Wassertheil-Smoller S, Hendrix S, Limacher M, et al. Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized controlled trial. JAMA. 2003;289:2673-2684.
28. Cauley JA, Robbins J, Chen Z, et al. Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. JAMA. 2003;290:1729-1738.
29. Espeland M, Rapp S, Shumaker S, et al. Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study. JAMA. 2004;291:2959-2968.
30. Shumaker S, Legault C, Kuller L, et al. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. JAMA. 2004;291:2947-2958.