CpG-oligodeoxynucleotides inhibit RSV-enhanced allergic sensitisation in guinea pigs

European Respiratory Journal

Volumn 25, Issue 2, 2005, Pages 295-302

  Tayyari, F ^a   Sutton, T C ^a   Manson, H E ^a   Hegele, R G ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Acute bronchiolitis; Allergy; Cytosine phosphate guanine oligodeoxynucleotides; Respiratory syncytial virus

Indexed keywords

CYTOSINE PHOSPHATE GUANINE OLIGODEOXYNUCLEOTIDE DERIVATIVE; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 5; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ALLERGIC REACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; EOSINOPHIL; FEMALE; GUINEA PIG; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; LUNG PARENCHYMA; NONHUMAN; PRIORITY JOURNAL; PROTECTION; QUANTITATIVE ANALYSIS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY TRACT INFLAMMATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH1 CELL; TH2 CELL; VIRUS INFECTION;

ANALYSIS OF VARIANCE; ANIMALS; CPG ISLANDS; FEMALE; GUINEA PIGS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERFERON TYPE II; INTERLEUKIN-5; OVALBUMIN; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 13844276557     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.05.00016304     Document Type: Article

References (32)

1. Hall CB. Respiratory syncytial virus and parainfluenza virus. N Engl J Med 2001; 344: 1917-1928.
2. Sigurs N, Bjarnason R, Sigurbergson F, Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 2000; 161: 1501-1507.
3. Schauer U, Hoffjan S, Bittscheidt J, et al. RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life. Eur Respir J 2002; 20: 1277-1283.
4. Schwarze J, Hamelmann E, Bradley KL, Takeda K, Gelfand EW. Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen. J Clin Invest 1997; 100: 226-233.
5. Hegele RG, Robinson PJ, Gonzalez S, Hogg JC. Production of acute bronchiolitis in guinea-pigs by human respiratory syncytial virus. Eur Respir J 1993; 6: 1324-1331.
6. Ishida K, Kelly LJ, Thomson RJ, Beattie LL, Schellenberg RR. Repeated antigen challenge induces airway hyperresponsiveness with tissue eosinophilia in guinea pigs. J Appl Physiol 1989; 67: 1133-1139.
7. al-Laith M, Weyer A, Havet N, Dumarey C, Vargaftig BB, Bachelet M. Immunoglobulin-G-dependent stimulation of guinea pig lung mast cells and macrophages. Allergy 1993; 48: 608-614.
8. Dakhama A, Bramley AM, Chan NG, McKay KO, Schellenberg RR, Hegele RG. Effects of respiratory syncytial virus on subsequent allergic sensitization to ovalbumin in guinea-pigs. Eur Respir J 1999; 13: 976-982.
9. Bramley AM, Khan MA, Manson HE, Hegele RG. Development of respiratory syncytial "bronchiolitis" in guinea pigs does not reflect an allergic predisposition in the host. Chest 2003; 124: 671-681.
10. Hamid Q, Song Y, Kotsimbos TC, et al. Inflammation of small airways in asthma. J Allergy Clin Immunol 1997; 100: 44-51.
11. Tripp RA. The brume surrounding respiratory syncytial virus persistence. Am J Respir Crit Care Med 2004; 169: 778-779.
12. Constant SL, Bottomly K. Induction of Th1 and Th2 CD4+ T-cell responses: the alternative approaches. Annu Rev Immunol 1997; 15: 297-322.
13. Roman M, Calhoun WJ, Hinton KL, et al. Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response. Am J Respir Crit Care Med 1997; 156: 190-195.
14. Kim CK, Kim SW, Park CS, Kim BI, Kang H, Koh YY. Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis. J Allergy Clin Immunol 2003; 112: 64-71.
15. Legg JP, Hussain IR, Warner JA, Johnston SL, Warner JO. Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med 2003; 168: 633-639.
16. O'Garra A, Arai N. The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol 2000; 10: 542-550.
17. Kline JN, Krieg AM. CpG oligodeoxynucleotides. Prog Respir Res 2001; 31: 229-232.
18. Mutwiri G, Pontarollo R, Babiuk S, et al. Biological activity of immunostimulatory CpG DNA motifs in domestic animals. Vet Immunol Immunopathol 2003; 91: 89-103.
19. Horner AA, Raz E. Immunostimulatory sequence oligodeoxynucleotide-based vaccination and immunomodulation: two unique but complementary strategies for the treatment of allergic diseases. J Allergy Clin Immunol 2002; 110: 706-712.
20. Canadian Council on Animal Care. Guide to the care and use of experimental animals. Ottawa, CCAC, 1980.
21. Kaan PM, Hegele RG. Interaction between respiratory syncytial virus and particulate matter in guinea pig alveolar macrophages. Am J Respir Cell Mol Biol 2003; 28: 697-704.
22. Kitagaki K, Businga TR, Kline JN. Differing effects of CpG-A and CpG-B on antigen stimulated immune responses. Am J Respir Crit Care Med 2004; 169: A717.
23. Tayyari F, Ashfaq MK, Manson HE, Hegele RH. Comparison of dose and route of administration of CpG oligonucleotide (CpG-ODN) on pulmonary Th1/Th2 cytokine balance in guinea-pigs. Am J Respir Crit Care Med 2003; 167: A724.
24. Churg A. An inflation procedure for open lung biopsies. Am J Surg Pathol 1983; 7: 69-71.
25. Nolan CR III, Anger MS, Kelleher SP. Eosinophiluria: a new method of detection and definition of the clinical spectrum. N Engl J Med 1986; 315: 1516-1519.
26. Rozen S, Skaletsky HJ. Primer 3 on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S, eds. Bioinformatics methods and protocols: methods in molecular biology. Totowa, Humana Press, 2000; pp. 365-386.
27. Sachs L. Applied statistics: a handbook of techniques. New York, Springler Verlag Publishers, 1982.
28. Rosner B. Hypothesis testing: categorical data. In: Fundamentals of biostatistics. Boston, Duxbury Press, 1982; pp. 171-224.
29. Estes DM, Brown WC. Type 1 and type 2 responses in regulation of Ig isotope expression in cattle. Vet Immunol Immunopathol 2002; 90: 1-10.
30. Lordan JL, Hellewell PG. Cytokines, chemokines, and adhesion proteins. In: Holgate ST, Church MK, Lichtenstein LM, eds. Allergy. 2nd Edn. London, Mosby, 2001; pp. 283-302.
31. Shirota H, Sano K, Kikuchi T, Tamura G, Shirato K. Regulation of T-helper type 2 cell and airway eosinophilia by transmucosal coadministration of antigen and oligodeoxynucleotides containing CpG motifs. Am J Respir Cell Mol Biol 2000; 22: 176-182.
32. Broide D, Schwarze J, Tighe H, et al. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice. J Immunol 1998; 161: 7054-7062.