Treatment with tetrahydrobiopterin reduces blood pressure in male SHR by reducing testosterone synthesis

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 288, Issue 3 57-3, 2005, Pages

  Fortepiani, Lourdes A ^a   Reckelhoff, Jane F ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Androgens; Castration; Hypertension; Nitric oxide; Oxidative stress

Indexed keywords

ANDROGEN; NITRIC OXIDE; SODIUM NITRITE; TESTOSTERONE; TETRAHYDROBIOPTERIN;

ADOLESCENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CASTRATION; CONTROLLED STUDY; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SPONTANEOUSLY HYPERTENSIVE RAT; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS;

ANIMALS; BIOPTERIN; BLOOD PRESSURE; DRUG ADMINISTRATION SCHEDULE; HYPERTENSION; MALE; NITRIC OXIDE DONORS; ORCHIECTOMY; RATS; RATS, INBRED SHR; SODIUM NITRITE; TESTOSTERONE;

EID: 13844256294     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00500.2004     Document Type: Article

References (20)

1. Cosentino F, Barker J, Brand M, Heales S, Werner E, Tippins J, West N, Channon K, Volpe M, and Luscher T. Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice. Arterioscler Thromb Vasc Biol 21: 496-502, 2001.
2. Csaba Z, Csernus V, and Gerendai I. Intratesticular serotonin affects steroidogenesis in the rat testis. J Neuroendocrinol 10: 371-376, 1998.
3. DelPunta K, Charreau E, and Pignataro O. Nitric oxide inhibits Leydig cell steroidogenesis. Endocrinology 137: 5337-5343, 1996.
4. Du J and Hull E. Effects of testosterone on neuronal nitic oxide synthase and tyrosine hydroxylase. Brain Res 836: 90-98, 1999.
5. Dunnett CW. A multiple comparison procedure for comparing several treatments with a control. J Am Statist Assoc 50: 1096-1121, 1955.
6. Elman I, Goldstein D, Adler C, Shoaf S, and Breier A. Inverse relationship between plasma epinephrine and testosterone levels during acute glucoprivation in healthy men. Life Sci: 1889-1898, 2001.
7. Hagag P, Hertzianu I, Ben-Schlomo A, and Weiss M. Androgen suppression and clinical improvement with dopamine agonists in hyperandrogenic- hyperprolactinemic women. J Reprod Med 46, 2001.
8. Hong H, Hsiao G, Cheng T, and Yen M. Supplementation with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. Hypertension 38: 1044-1048, 2001.
9. Ide T, Tsutsui H, Ohashi N, Hayashidani S, Suematsu N, Tsuchihyasm M, Tamai H, and Takeshita A. Greater oxidative stress in healthy young men compared with premenopausal women. Arterioscler Thromb Vasc Biol 22: 1239-1242, 2002.
10. Iliescu R, Campos L, Schlegel W, Morano I, Baltatu O, and Bader M. Androgen receptor independent cardiovascular action of the antiandrogen flutamide. J Mol Med 81: 420-427, 2003.
11. Kostic T, Andric S, Maric D, and Kovacevic R. Inhibitory effects of stress-activated nitric oxide on antioxidant enzymes and testicular steroidogenesis. J Steroid Biochem Mol Biol 75: 299-306, 2000.
12. Landmesser U, Dikalov S, Price S, McCann L, Fukai T, Holland S, Mitch W, and Harrison D. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 111: 1201-1209, 2003.
13. Reckelhoff JF, Kanji V, Racusen LC, Schmidt AM, Yan SD, Morrow JD, Roberts LJ, II, and Salahudeen AK. Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys. Am J Physiol Regul Integr Comp Physiol 274: R767-R774, 1998.
14. Reckelhoff JF and Kellum J. Changes in nitric oxide precursor, L-arginine, and metabolites, nitrate and nitrite, with aging. Life Sci 55: 1895-1902, 1994.
15. Reckelhoff JF, Zhang H, and Granger JP. Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats. Hypertension 31: 435-439, 1998.
16. Reckelhoff JF, Zhang H, and Srivastava K. Gender differences in the development of hypertension in SHR: Role of the renin-angiotensin system. Hypertension 35: 480-483, 2000.
17. Reckelhoff JF, Zhang H, Srivastava K, Granger JP. Gender differences in hypertension in spontaneously hypertensive rats. Role of androgens and androgen receptor. Hypertension 34: 920-923, 1999.
18. Rehavi M, Attali G, Gil-Ad I, and Weizman A. Suppression of serum gonadal steroids in rats by chronic treatment with dopamine and serotonin reuptake inhibitors. Eur Neuropsychopharmacol 10: 145-150, 2000.
19. Romeo R, Pellitteri R, Russo A, and Marcello M. Catecholaminergic phenotype of human Leydig cells. Itl J Anat Ebryol 109, 2004.
20. Thony B, Auerbach G, and Blau N. Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem J 347: 1-16, 2000.