Mechanism of the stimulatory effect of native fucoidan, highly sulfated fucoidan and heparin on plasminogen activation by tissue plasminogen activator: The role of chloride

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 29, Issue 4, 2004, Pages 269-275

  Lang, DeShawn ^a   Williams, Talya ^a   Phillips, Altovise ^a   Doctor, V M ^a  

^a PRAIRIE VIEW A AND M UNIVERSITY   (United States)

Author keywords

Fucoidan; Heparin; Plasminogen; Sodium chloride; Tissue plasminogen activator

Indexed keywords

ALTEPLASE; AMINOCAPROIC ACID; CHLORIDE; FUCOIDIN; GLUTAMIC PLASMINOGEN; HEPARIN; PLASMIN; SODIUM CHLORIDE; SULFATE; SULFATED FUCOIDIN; TISSUE PLASMINOGEN ACTIVATOR; TROMETAMOL; UNCLASSIFIED DRUG;

ANTICOAGULATION; ARTICLE; CIRCULAR DICHROISM; DRUG MECHANISM; DRUG POTENTIATION; IN VITRO STUDY; PH; PLASMINOGEN ACTIVATION; ULTRAVIOLET RADIATION;

EID: 13844255319     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190610     Document Type: Article

References (26)

1. Rosenberg D., Damus P.S. (1973) The purification and mechanism of action of human antithrombin-heparin cofactor. J. Biol. Chem.; 248:6490-6505.
2. Olson S.T. (1988) Transient kinetics of heparin-catalyzed protease inactivation by anitithrombin III. J. Biol. Chem.; 263:1689-1708.
3. Barrowcliffe T.W., Thomas O.P. (1987) Antithrombin III and heparin. In: Bloom A.L., Thomas O.P. (editors): Haemostasis md thrombosis. 2nd ed. Edinburgh: Churchill Livingstone. pp. 849-869.
4. Andrade-Gordon P., Strickland S. (1986) Interaction of heparin with plasminogen activators and plasminogen: effects on the activation of plasminogen. Biochemistry. 25:4033-4040.
5. Pagues E.P., Stohr H.A., Heimburger N. (1986) Study on the mechanism of action of heparin and related substance on the fibrinolytic system. Relationship between plasminogen activators and heparin. Thromb Res; 42:797-807.
6. Edelberg J.M., Pizzo S.V. (1990) Kinetic analysis of the effects of heparin and lipoproteins on tissue plasminogen activator mediated plasminogen activation. Biochemistry. 29:5906-5911.
7. Takada Y., Urano T., Takada A. (1994) Effects of heparan sulfate analogue or other sulfated polysaccharides on the activation of plasminogen by t-PA or u-PA. Thromb Res; 73:301-311.
8. plasminogen activators. Biochem. J; 249:77-81.
9. Springer G.R., Wurzel H.A., McNeil G.M. Jr., Ansell N., Doughty M.F. (1957) Isolation of anticoagulant fraction from crude fucoidan. Proc Soc Exp Biol Med; 94:404-409.
10. Bernardi G., Springer G. (1962) Properties of highly purified fucan. J Biol Chem.; 237:75-80.
11. Church F.C., Meade J.B., Treanor R.E., Whinmi H.C. (1989) Antithrombin activity of fucoidan. J Biol Chem.; 264:3618-3623.
12. Minix R., Doctor V.M. (1997) Interaction of fucoidan with proteases and inhibitors of coagulation and fibrinolysis. Thromb Res; 87:419-429.
13. Hogg P.J., Jackson C.M. (1989) Fibrin monomer protects thrombin from inactivation by heparin antithrombin III. Implications for heparin efficacy. Proc Nat Acad Sci USA; 86:3619-3623.
14. Hogg P.J., Jackson C.M. (1990) Heparin promotes the binding of thrombin to fibrin polymer. J Biol Chem.; 265:241-247.
15. Chauvet P., Bienvenu J.G., Theuret J.F., Latour J.G., Merhi Y. (1999) Inhibition of platelet-neutrophil interactions by fucoidan reduces adhesion and vasoconstriction after acute injury by angioplasty in pigs. J Cardiovasc Pharmacol; 34:597-603.
16. Soeda S., Sakaguchi S., Shimen H., Nagamatsu A. (1992) Fibrinolytic and anticoagulant activities of highly sulfated fucoidan. Biochem. Pharmacol; 43:1853-1858.
17. Liang J.F., Li Y., Yang V.C. (2000) The potential mechanism for the effect of heparin on tissue plasminogen activator-mediated plasminogen activation. Thromb Res; 97:349-358.
18. Dace R., McBride E., Brooks K., Gander J., Buszko M., Doctor V.M. (1997) Comparison of the anticoagulant action of sulfated and phosphorylated polysaccharides. Thrombosis Research. 87:113-121.
19. Doctor V.M., Hill C., Jackson GJ. (1995) Effect of fucoidan during activation of human plasminogen. Thrombosis Research. 70:237-247.
20. Bell J., Duhon S., Doctor V.M. (2003) The effect of fucoidan, heparin, and cyanogens bromide-fibrinogen on the activation of human glutamic-plasminogen by tissue plasminogen activator. Blood Coagulation and Fibrinolysis. 14:229-234.
21. Markus G., Depasquale J.L., Wissler F.C. (1978) Quantitative determination of the binding of epsilon-amino caproic acid to native plasminogen. J Biol Chem.; 253:723-732.
22. Sioholm I., Wiman B., Wallen P. (1973) Studies on the conformational changes of plasminogen induced during activation to plasmin and by 6-aminohexanoicacid. Euro J Biochem.; 39:471-479.
23. Mangel W.F., Lin B.H., Ramakrishnan V. (1990) Characterization of an extremely large ligand-induced conformational change in plasminogen. Science. 248:69-73.
24. McCance S.G., Castellino F.C. (1995) Contributions of individual kringle domains towards maintenance of the chloride-induced tight conformation of human glutamic acid-plasminogen. Biochemistry. 34:9581-9586.
25. Urano T., Bakshy A., Chibber K., Castellino F.J. (1987) The reciprocal effects of ε-aminohexanoic acid and chloride ion on the activation of human [Glu] plasminogen by human urokinase. Proc Natl Acad Sci USA; 84:4031-4034.
26. Guinn L., Johnson J., Doctor V.M. (2003) Ionic modulation of the effects of heparin and 6-aminohexanoic acid on plasminogen activation by streptokinase: The role of ionic strength, divalent cations and chloride. Euro J Drug Metabolism and Pharmacokinetics. 28:161-166.