Ionic modulation of the effects of heparin and 6-aminohexanoic acid on plasminogen activation by streptokinase: The role of ionic strength, divalent cations and chloride

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 28, Issue 2, 2003, Pages 161-166

  Guinn, L ^a   Johnson, J ^a   Doctor, V M ^a,b  

^a Praide View A and M University   (United States)

^b PRAIRIE VIEW A AND M UNIVERSITY   (United States)

Author keywords

6 aminohexanoic acid; Heparin; Plasminogen; Sodium chloride; Streptokinase

Indexed keywords

AMINOCAPROIC ACID; BUFFER; CHLORIDE; DIVALENT CATION; HEPARIN; HYDROCHLORIC ACID; PLASMINOGEN; SODIUM CHLORIDE;

ARTICLE; CIRCULAR DICHROISM; DILUTION; DRUG MECHANISM; ENZYME ACTIVATION; FIBRINOLYSIS; IONIC STRENGTH; PH MEASUREMENT; PLASMINOGEN ACTIVATION; SPECTROSCOPY; ULTRAVIOLET RADIATION;

EID: 0038780865     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190506     Document Type: Article

References (17)

1. Caplan L.R., Mohr J.P., Kistler J.P., Koroshetz D.J. (1997): Should thrombolytic therapy be the first line of treatment for acute ischemic stroke? N. England Journal of Medicine, 337, 1309-1310.
2. Brogden R.N., Speight T.M., Avery G.S. (1973): Streptokinase: A review of clinical pharmacology, mechanism of action and therapeutic uses. Drugs., 5, 357-445.
3. Kosow D.P. (1975): Kinetic mechanism of the activation of human plasminogen by streptokinase. Biochemistry, 14, 4459-4465.
4. Topol E.J., Barry S.G., Kereiakes D.J. (1989): A randomized controlled trial of intravenous tissue plasminogen activator and early intravenous heparin in acute myocardial infarction. Circulation, 79, 281-286.
5. Serrano R.L., Rodriquez P., Salvatore V.P., Gonzales-Gronow M. (1996): ATP-regulated activity of the plasmin-streptokinase complex; a novel mechanism involving phosphorylation of streptokinase. Biochemical Journal, 313, 155-161.
6. Doctor V.M., Hill C., Jackson G.J. (1995): Effect of fucoidan during activation of human plasminogen. Thrombosis Research, 79, 237-247.
7. Sjoholm I., Wiman B., Wallen P. (1973): Studies on conformational changes of plasminogen induced during activation to plasmin by 6-aminohexanoic acid. European Journal of Biochemistry, 39, 471-479.
8. Brockway W.J., Castellino F.J. (1971): The mechanism of inhibition of plasmin activity by ε-aminocaproic acid. Journal of Biological Chemistry, 246, 4641-4644.
9. Bakshy A., Chibber K., Castellino F.J. (1986): Regulation of streptokinase-mediated activation of human plasminogen by fibrinogen and chloride ions. Journal of Biological Chemistry, 261, 5289-5295.
10. Urano T., Bakshy A., Chibber K., Castellino F.J. (1987): The reciprocal effects of ε-aminohexanoic acid and chloride ion on the activation of human [Glu] plasminogen by human urokinase. Proc. Nat'l. Acad. Sci., 84, 4031-4034.
11. Taylor F.B., Botts J. (1968): Purification and characterization of streptokinase with studies of streptokinase activation of plasminogen. Biochemistry, 7, 232-238.
12. Brockway W.J., Castellino F.J. (1974): Characterization of native streptokinase and altered streptokinase isolated from a human plasminogen activator complex. Biochemistry, 13, 2063-2070.
13. Jackson K.W., Tang J. (1982): Complete amino acid sequence of streptokinase and its homology with serine proteases. Biochemistry, 21, 6620-6625.
14. Wang X., Lin X., Loy J.A., Tang J., Zhang X.C. (1998): Crystal structure of the catalytic domain of human plasmin complexed with streptokinase. Science, 281, 1662-1665.
15. Kornblatt J.A., Rajotte I., Heitz F. (2001): Reaction of canine plasminogen with 6-aminohexanoate; A thermodynamic study combining fluorescence, circular dichroism, and isothermal titration calorimetry. Biochemistry, 40, 3639-3647.
16. Ray M.J., Hales M., March N. (2001): Epsilon-aminocaproic acid promotes the release of α2-antiplasmin during and after cardiopulmonary bypass. Blood Coagulation and Fibrinolysis, 12, 129-135.
17. Harris G., Doctor V.M. (2002): The effect of 6-aminohexanoic acid and fucoidan on the activation of glutamic plasminogen by streptokinase. Blood Coagulation and Fibrinolysis, 13, 355-359.