메뉴 건너뛰기




Volumn 99, Issue 8, 2004, Pages 831-837

Trypanosoma cruzi: Inhibition of α-hydroxyacid dehydrogenase isozyme II by N-allyl and N-propyl oxamates and their effects on intact epimastigotes

Author keywords

Ethyl N allyl oxamate; Ethyl N propyl oxamate; N allyl oxamate; N propyl oxamate; Trypanosoma cruzi; Trypanosoma cruzi hydroxyacid dehydrogenase isozyme II inhibition; hydroxyacid dehydrogenase

Indexed keywords

2 HYDROXYACID DEHYDROGENASE; ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; ENZYME INHIBITOR; ESTER DERIVATIVE; ETHYL N ALLYLOXAMATE; ETHYL N PROPYLOXAMATE; ISOENZYME; N ALLYLOXAMATE; N PROPYLOXAMATE; NIFURTIMOX; NITROGEN; OXAMIC ACID; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

EID: 13844254062     PISSN: 00740276     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0074-02762004000800009     Document Type: Article
Times cited : (7)

References (35)
  • 3
    • 0033977087 scopus 로고    scopus 로고
    • Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs
    • Bakker BM, Westerhoff HV, Opperdoes FR, Michels PAM 2000. Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs. Mol Biochem Pharmacol 106: 1-10.
    • (2000) Mol Biochem Pharmacol , vol.106 , pp. 1-10
    • Bakker, B.M.1    Westerhoff, H.V.2    Opperdoes, F.R.3    Michels, P.A.M.4
  • 4
    • 0020898943 scopus 로고
    • Effect of gossypol upon motility and ultrastructure of Trypanosoma cruzi
    • Blanco A, Aoqui A, Montamat E, Rovai L 1983. Effect of gossypol upon motility and ultrastructure of Trypanosoma cruzi. J Protozool 30: 643-651.
    • (1983) J Protozool , vol.30 , pp. 643-651
    • Blanco, A.1    Aoqui, A.2    Montamat, E.3    Rovai, L.4
  • 6
    • 73649161135 scopus 로고
    • Therapeutic activity and criterion of cure in mice experimentally infected with Trypanosoma cruzi
    • Brener Z 1962. Therapeutic activity and criterion of cure in mice experimentally infected with Trypanosoma cruzi. Rev Inst Med Trop São Paulo 4: 389-396.
    • (1962) Rev Inst Med Trop São Paulo , vol.4 , pp. 389-396
    • Brener, Z.1
  • 8
    • 0024828846 scopus 로고
    • Hemocultures for the parasitological diagnosis of human chronic Chagas' disease
    • Chiari E, Diaz J C, Lana M, Chiari C A 1989. Hemocultures for the parasitological diagnosis of human chronic Chagas' disease. Rev Soc Bras Med Trop 22: 19-23.
    • (1989) Rev Soc Bras Med Trop , vol.22 , pp. 19-23
    • Chiari, E.1    Diaz, J.C.2    Lana, M.3    Chiari, C.A.4
  • 9
    • 0020724496 scopus 로고
    • Catalytic properties of the sperm specific lactate dehydrogenase (LDH-x or C4) from different species
    • Coronel CE, Burgos C, Gerez de Burgos NMC, Rovai E, Blanco A 1983. Catalytic properties of the sperm specific lactate dehydrogenase (LDH-x or C4) from different species. J Exp Zool 225: 379-385.
    • (1983) J Exp Zool , vol.225 , pp. 379-385
    • Coronel, C.E.1    Burgos, C.2    Gerez De Burgos, N.M.C.3    Rovai, E.4    Blanco, A.5
  • 10
    • 0022529027 scopus 로고
    • Properties of the branched-chain-2-hydroxyacid/ 2-oxoacid shuttle in mouse spermatozoa
    • Coronel CE, Gallina FG, Gerez de Burgos NM, Burgos C, Blanco A 1986. Properties of the branched-chain-2-hydroxyacid/ 2-oxoacid shuttle in mouse spermatozoa. Biochem J 235: 853-858.
    • (1986) Biochem J , vol.235 , pp. 853-858
    • Coronel, C.E.1    Gallina, F.G.2    Gerez De Burgos, N.M.3    Burgos, C.4    Blanco, A.5
  • 11
    • 0037819555 scopus 로고
    • Separación y propiedades catalíticas de las isoenzimas de la α-hidroxiácido deshidrogenasa de Trypanosoma cruzi
    • Coronel C, Gerez de Burgos NM, Burgos C, Blanco A 1980. Separación y propiedades catalíticas de las isoenzimas de la α- hidroxiácido deshidrogenasa de Trypanosoma cruzi. Medicina (Buenos Aires) 40: 159-164.
    • (1980) Medicina (Buenos Aires) , vol.40 , pp. 159-164
    • Coronel, C.1    Gerez De Burgos, N.M.2    Burgos, C.3    Blanco, A.4
  • 14
    • 0001422064 scopus 로고
    • Glucose-6-phosphate dehydrogenase
    • Deutsch J 1995. Glucose-6-phosphate dehydrogenase. Meth Enzym Analysis 3: 190-197.
    • (1995) Meth Enzym Analysis , vol.3 , pp. 190-197
    • Deutsch, J.1
  • 16
    • 0017939092 scopus 로고
    • Formas moleculares de α-hidroxiácido deshidrogenasa en Trypanosoma cruzi
    • Gerez de Burgos NM, Blanco A, Segura EL 1978. Formas moleculares de α-hidroxiácido deshidrogenasa en Trypanosoma cruzi. Medicina (Buenos Aires) 38: 151-154.
    • (1978) Medicina (Buenos Aires) , vol.38 , pp. 151-154
    • Gerez De Burgos, N.M.1    Blanco, A.2    Segura, E.L.3
  • 18
    • 0018192381 scopus 로고
    • Purification and some properties of the NADP-linked glutamate dehydrogenase from Trypanosoma cruzi
    • Juan S, Segura EL, Cazzulo JJ 1978. Purification and some properties of the NADP-linked glutamate dehydrogenase from Trypanosoma cruzi. Int J Biochem 9: 95-400.
    • (1978) Int J Biochem , vol.9 , pp. 95-400
    • Juan, S.1    Segura, E.L.2    Cazzulo, J.J.3
  • 20
    • 0023812484 scopus 로고
    • Compartimentation of glycolysis in trypanosomes: A potential target for new trypanocidal drugs
    • Michels PAM 1988. Compartimentation of glycolysis in trypanosomes: a potential target for new trypanocidal drugs. Biol Cell 64: 157-164.
    • (1988) Biol Cell , vol.64 , pp. 157-164
    • Michels, P.A.M.1
  • 21
    • 0023103912 scopus 로고
    • Subcellular localization of leucin amino transferase and α-hydroxyacid dehydrogenase in Trypanosoma cruzi
    • Montamat EE, Arauzo SS, Blanco A 1987. Subcellular localization of leucin amino transferase and α-hydroxyacid dehydrogenase in Trypanosoma cruzi. Mol Biochem Parasitol 22: 185-193.
    • (1987) Mol Biochem Parasitol , vol.22 , pp. 185-193
    • Montamat, E.E.1    Arauzo, S.S.2    Blanco, A.3
  • 22
    • 0019940628 scopus 로고
    • Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi
    • Montamat EE, Burgos C, Gerez de Burgos NM 1982. Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi. Science 218: 288-289.
    • (1982) Science , vol.218 , pp. 288-289
    • Montamat, E.E.1    Burgos, C.2    Gerez De Burgos, N.M.3
  • 23
    • 0023812367 scopus 로고
    • Subcellular localization of branched-chain aminoacid amino transferase and lactate dehydrogenase C4 in rat and mouse spermatozoa
    • Montamat EE, Vermouth NT, Blanco A 1988. Subcellular localization of branched-chain aminoacid amino transferase and lactate dehydrogenase C4 in rat and mouse spermatozoa. Biochem J 255: 1053-1056.
    • (1988) Biochem J , vol.255 , pp. 1053-1056
    • Montamat, E.E.1    Vermouth, N.T.2    Blanco, A.3
  • 24
    • 0034876644 scopus 로고    scopus 로고
    • Trypanocidal activity of 4-isopropyl salicylaldehyde and 4-isopropyl salicylic acid on Trypanosoma cruzi
    • Nogueda TB, Rodríguez-Páez L, Baeza I, Wong C 2001. Trypanocidal activity of 4-isopropyl salicylaldehyde and 4-isopropyl salicylic acid on Trypanosoma cruzi. Rev Latamer Microbiol 43: 1-6.
    • (2001) Rev Latamer Microbiol , vol.43 , pp. 1-6
    • Nogueda, T.B.1    Rodríguez-Páez, L.2    Baeza, I.3    Wong, C.4
  • 25
    • 0035339822 scopus 로고    scopus 로고
    • Enzymes of carbohydrate metabolism as potential drug targets
    • Opperdoes FR, Michels PA 2001. Enzymes of carbohydrate metabolism as potential drug targets. Int J Parasitol 31: 482-490.
    • (2001) Int J Parasitol , vol.31 , pp. 482-490
    • Opperdoes, F.R.1    Michels, P.A.2
  • 26
    • 0020995450 scopus 로고
    • Trypanosoma cruzi: Carboxylesterase activity in intact epimastigotes
    • Repetto Y, Aldunate J, Morello A 1983. Trypanosoma cruzi: carboxylesterase activity in intact epimastigotes. Comp Biochem Physiol B 76: 61-64.
    • (1983) Comp Biochem Physiol B , vol.76 , pp. 61-64
    • Repetto, Y.1    Aldunate, J.2    Morello, A.3
  • 28
    • 0028203817 scopus 로고
    • Chagas' disease: Carcinogenic activity of the antitrypanocidal nitroarenes in mice
    • Teixeira AR, Clixto MA, Teixeira ML 1994. Chagas' disease: carcinogenic activity of the antitrypanocidal nitroarenes in mice. Mutation Res 305: 189-196.
    • (1994) Mutation Res , vol.305 , pp. 189-196
    • Teixeira, A.R.1    Clixto, M.A.2    Teixeira, M.L.3
  • 32
    • 0028949538 scopus 로고
    • Molecular mechanism and therapeutic approaches to the treatment of African trypanosomiasis
    • Wang CC 1995. Molecular mechanism and therapeutic approaches to the treatment of African trypanosomiasis. Ann Rev Pharmacol Toxicol 35: 93-127.
    • (1995) Ann Rev Pharmacol Toxicol , vol.35 , pp. 93-127
    • Wang, C.C.1
  • 33
    • 0344542034 scopus 로고    scopus 로고
    • Selective inhibition of sperm-specific lactate dehydrogenase isozyme-C4 by N-isopropyl oxamate
    • Wong C, Rodríguez-Páez L, Nogueda B, Pérez A, Baeza I 1997. Selective inhibition of sperm-specific lactate dehydrogenase isozyme-C4 by N-isopropyl oxamate. Biochim Biophys Acta 1343: 16-22.
    • (1997) Biochim Biophys Acta , vol.1343 , pp. 16-22
    • Wong, C.1    Rodríguez-Páez, L.2    Nogueda, B.3    Pérez, A.4    Baeza, I.5
  • 34
    • 0036294520 scopus 로고    scopus 로고
    • Control of Chagas disease
    • WHO Expert Committee
    • WHO-World Health Organization. 2002. Control of Chagas disease. WHO Expert Committee. WHO Tech Rep Ser 905: 1-109.
    • (2002) WHO Tech Rep Ser , vol.905 , pp. 1-109
  • 35
    • 0000770461 scopus 로고
    • L-malate dehydrogenase
    • Yoshida A 1969. L-malate dehydrogenase. Meth Enzymol 13: 141-145.
    • (1969) Meth Enzymol , vol.13 , pp. 141-145
    • Yoshida, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.