Modafinil treatment for fatigue in HIV+ patients: A pilot study

Journal of Clinical Psychiatry

Volumn 65, Issue 12, 2004, Pages 1688-1695

  Rabkin, Judith G ^a,b   McElhiney, Martin C ^a,b   Rabkin, Richard ^a   Ferrando, Stephen J ^c  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; BENZHYDRYL DERIVATIVE; CENTRAL STIMULANT AGENT; MODAFINIL; VIRUS RNA;

ADULT; AGED; ARTICLE; BLOOD; CD4 LYMPHOCYTE COUNT; CLINICAL TRIAL; COMORBIDITY; DEPRESSION; DRUG COMBINATION; DRUG EFFECT; FATIGUE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PERSONALITY TEST; PILOT STUDY; PSYCHOLOGICAL RATING SCALE; STATISTICS; TREATMENT OUTCOME; VIRUS LOAD;

ADULT; AGED; ANTI-RETROVIRAL AGENTS; BENZHYDRYL COMPOUNDS; CD4 LYMPHOCYTE COUNT; CENTRAL NERVOUS SYSTEM STIMULANTS; COMORBIDITY; DEPRESSIVE DISORDER; DRUG THERAPY, COMBINATION; FATIGUE; FEMALE; HIV; HIV INFECTIONS; HIV SEROPOSITIVITY; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PERSONALITY INVENTORY; PILOT PROJECTS; PSYCHIATRIC STATUS RATING SCALES; RNA, VIRAL; TREATMENT OUTCOME; VIRAL LOAD;

EID: 13744250926     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.v65n1215     Document Type: Article

References (41)

1. Breitbart W, McDonald M, Rosenfeld B, et al. Fatigue in ambulatory AIDS patients. J Pain Symptom Manage 1998;15:159-167
2. Vogl D, Rosenfeld B, Breitbart W, et al. Symptom prevalence, characteristics and distress in AIDS outpatients. J Pain Symptom Manage 1999; 19:253-262
3. Sullivan P, Dworkin M. Prevalence and correlates of fatigue among persons with HIV infection. J Pain Symptom Manage 2003;25:329-333
4. Ferrando S, Evans S, Goggin K, et al. Fatigue in HIV illness: relationship to depression, physical limitations and disability. Psychosom Med 1998; 60:759-764
5. Duran S, Spire B, Raffi F, et al. Self-reported symptoms after initiation of a protease inhibitor in HIV-infected patients and their impact on adherence to HAART. HIV Clin Trials 2001;2:38-45
6. Molassiotis A, Callighan P, Twinn SF, et al. Correlates of quality of life in symptomatic HIV patients living in Hong Kong. AIDS Care 2001;13: 319-334
7. Lieberman HR, Tharion W, Shukitt-Hale B, et al. Effects of caffeine, sleep loss and stress on cognitive performance and mood during US Navy SEAL training: Sea-Air-Land. Psychopharmacology (Berl) 2002;164:250-261
8. Lorist MM, Kernell D, Meijman T, et al. Motor fatigue and cognitive task performance in humans. J Physiol 2002;545(pt 1):313-319
9. Millikin C, Rourke S, Halman M, et al. Fatigue in HIV/AIDS is associated with depression and subjective neurocognitive complaints but not neuropsychological functioning. J Clin Exp Neuropsychol 2003;25: 201-215
10. Breitbart W, Rosenfeld B, Kaim M, et al. A randomized, double-blind, placebo-controlled trial of psychostimulants for the treatment of fatigue in ambulatory patients with HIV disease. Arch Intern Med 2001;161: 411-420
11. Rabkin JG. Psychostimulant medication for depression and lethargy in HIV illness: a pilot study. Newsletter of the Am Soc Clinical Psychopharmacology 1993;4:1
12. Wagner GJ, Rabkin R. Effects of dextroamphetamine on depression and fatigue in men with HIV: a double-blind, placebo-controlled trial. J Clin Psychiatry 2000;61:436-440
13. Rabkin J, Wagner G, Rabkin R. Testosterone therapy for HIV+ men with and without hypogonadism. J Clin Psychopharmacol 1999;19:19-27
14. Rabkin J, Wagner G, Rabkin R. A double-blind, placebo controlled trial of testosterone therapy for HIV+ men with hypogonadal symptoms. Arch Gen Psychiatry 2000;57:141-147
15. Scammell T, Estabrooke I, McCarthy M, et al. Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci 2000;20:8620-8628
16. Stahl SM, Zhang L, Damatarca C, et al. Brain circuits determine destiny in depression: a novel approach to the psychopharmacology of wakefulness, fatigue, and executive dysfunction in major depressive disorder. J Clin Psychiatry 2003;64(suppl 14):6-17
17. Silvestri A, Sanford L, Ross RJ, et al. The central nucleus of the amygdala and the wake-promoting effects of modafinil. Brain Res 2002;94: 43-52
18. Robertson P, Hellriegel E, Arora S, et al. Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers. Clin Pharmacol Ther 2002;71:46-56
19. Wong YN, Simcoe D, Hartman L, et al. A double-blind, placebocontrolled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers. J Clin Pharmacol 1999;39:30-40
20. Rush C, Kelly T, Hays L, et al. Discriminative-stimulus effects of modafinil in cocaine-trained humans. Drug Alcohol Depend 2002; 67:311-322
21. O'Malley M. Neurobiology of fatigue and excessive daytime sleepiness. In: Treating Symptoms of Common Psychiatric Disorders: An Update. Clinical Psychiatry News Supplement 2003:6-8
22. Turner D, Robbins T, Clark L, et al. Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology (Berl) 2003; 165:260-269
23. Rammohan K, Rosenberg J, Lynn D, et al. Efficacy and safety of modafinil (Provigil) for the treatment of fatigue in multiple sclerosis: a two center phase 2 study. J Neurol Neurosurg Psychiatry 2002;72: 179-183
24. Adler C, Caviness J, Hentz J, et al. Effect of modafinil on excessive daytime sleepiness associated with Parkinson disease [abstract]. Sleep 2001;24(abstract suppl):A368
25. Damian M, Gerlach A, Schmidt F, et al. Modafinil for excessive daytime sleepiness in myotonic dystrophy. Neurology 2001;56:794-796
26. DeBattista C. Recognizing and treating patients with executive function deficit syndrome. In: Treating Symptoms of Common Psychiatric Disorders: An Update. Clinical Psychiatry News Supplement 2003: 14-15
27. Krupp L, LaRocca N, Muir-Nash J, et al. The Fatigue Severity Scale. Arch Neurol 1989;46:1121-1123
28. Johns M. A new method for measuring daytime sleepiness: The Epworth Sleepiness Scale. Sleep 1991;14:540-545
29. Chalder T, Berelowitz G, Pawlkowska T, et al. Development of a fatigue scale. J Psychosom Res 1993;37:147-153
30. Guy W. ECDEU Assessment Manual for Psychopharmacology. US Dept Health, Education and Welfare publication (ADM) 76-338. Rockville, Md: National Institute of Mental Health; 1976;218-222
31. First M, Spitzer R, Gibbon M, et al. Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition (SCID I/P, version 2.0). New York, NY: Biometrics Research Department, New York State Psychiatric Institute; 1996
32. Williams JBW. A Structured Interview Guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry 1988;45:742-747
33. Beck AT, Steer R. BDI-II Manual. San Antonio, Tex: Psychological Corp; 1987
34. Rabkin JG, Markowitz J, Ocepek-Welikson K, et al. General vs systematic inquiry about emergent clinical events with SAFTEE: implications for clinical research. J Clin Psychopharmacol 1992;12:3-10
35. Spreen O, Strauss E. A Compendium of Neuropsychological Tests. 2nd ed. New York, NY: Oxford; 1998:326-340
36. Wechsler D. Wechsler Adult Intelligence Scale. 3rd ed. San Antonio, Tex: Psychological Corp; 1997
37. D'Elia L, Satz P, Uchiyama C, et al. Color Trails Test. Odessa, Fla: Psychological Assessment Resources Inc; 1996
38. Golden J. Stroop Color and Word Test. Chicago, Ill: Stoetling; 1978
39. Lezak M. Neuropsychological Assessment. 3rd ed. New York, NY: Oxford; 1995
40. Miller EN, Satz P, Visscher B. Computerized and conventional neuropsychological assessment of HIV-1 infected homosexual men. Neurology 1991;41:1608-1616
41. Rabkin JG, McElhiney M, Ferrando S, et al. Predictors of employment of men with HIV/AIDS: a longitudinal study. Psychosom Med 2004;66: 72-78