A role for CagA/VacA in Helicobacter pylori inhibition of murine duodenal mucosal bicarbonate secretion

Digestive Diseases and Sciences

Volumn 49, Issue 11-12, 2004, Pages 1845-1852

  Tuo, Bi Guang ^a,b   Sellers, Zachary M ^a   Smith, Anders J ^a   Barrett, Kim E ^a   Isenberg, Jon I ^d   Dong, Hui ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UCSD MEDICAL CENTER   (United States)

^d NONE

Author keywords

CagA; Duodenal bicarbonate secretion; Helicobacter pylori; VacA

Indexed keywords

ADENYLATE CYCLASE; BICARBONATE; CAGA PROTEIN; CALCIMYCIN; CALCIUM ION; CARBACHOL; CYCLIC AMP; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; PROSTAGLANDIN E2; VACUOLATING TOXIN; WATER;

ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DUODENUM MUCOSA; DUODENUM ULCER; GASTROINTESTINAL SECRETION; HELICOBACTER PYLORI; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHORT CIRCUIT CURRENT;

EID: 13644271401     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-004-9582-3     Document Type: Article

References (40)

1. 1. Flemström G 1994 Gastric and duodenal mucosal secretion of bicarbonate Johnson L In Physiology of the Gastrointestinal Tract Raven Press New York 1285 1309 Flemström G: Gastric and duodenal mucosal secretion of bicarbonate. In Physiology of the Gastrointestinal Tract. Johnson L (ed). New York, Raven Press, 1994, pp 1285–1309
2. 2. G Flemström J Isenberg 2001 Gastroduodenal mucosal alkaline secretion and mucosal protection News Physiol Sci 16 23 28 11390942 Flemström G, Isenberg J: Gastroduodenal mucosal alkaline secretion and mucosal protection. News Physiol Sci 16:23–28, 2001
3. 3. D Hogan M Ainsworth J Isenberg 1994 Gastroduodenal bicarbonate secretion Aliment Pharmacol Ther 8 475 488 10.1111/j.1365-2036.1994.tb00319.x 7865639 1:STN:280:DyaK2M7mvFynsg%3D%3D Hogan D, Ainsworth M, Isenberg J: Gastroduodenal bicarbonate secretion. Aliment Pharmacol Ther 8:475–488, 1994
4. 4. L Hojgaard A Mertz-Nielson S Rune 1996 Peptic ulcer pathophysiology: Acid, bicarbonate, and mucosal function Scand J Gastroenterol 216 10 15 1:STN:280:DyaK283psVygug%3D%3D Hojgaard L, Mertz-Nielson A, Rune S: Peptic ulcer pathophysiology: Acid, bicarbonate, and mucosal function. Scand J Gastroenterol 216:10–15, 1996
5. 5. M Guba M Kuhn W Forssmann 1996 Guanylin strongly stimulates rat duodenal HCO 3 − secretion: Proposed mechanism and comparison with other secretagogues Gastroenterology 111 1558 1568 8942735 1:CAS:528:DyaK2sXisVWjtQ%3D%3D Guba M, Kuhn M, Forssmann W, et al.: Guanylin strongly stimulates rat duodenal HCO3− secretion: Proposed mechanism and comparison with other secretagogues. Gastroenterology 111:1558–1568, 1996
6. 6. J Heylings H Garner G Flemstrom 1984 Regulation of gastroduodenal HCO 3 − transport by luminal acid in the frog in vitro Am J Physiol 246 G235 G240 6608277 1:CAS:528:DyaL2cXhs1ykt70%3D Heylings J, Garner H, Flemstrom G: Regulation of gastroduodenal HCO3− transport by luminal acid in the frog in vitro. Am J Physiol 246:G235–G240, 1984
7. 7. D Hogan B Yao J Isenberg 1998 Modulation of bicarbonate secretion in rabbit duodenum: the role of calcium Dig Dis Sci 43 120 125 10.1023/A:1018836407044 9508512 1:CAS:528:DyaK1cXhsVKjtr8%3D Hogan D, Yao B, Isenberg J: Modulation of bicarbonate secretion in rabbit duodenum: the role of calcium. Dig Dis Sci 43:120–125, 1998
8. 8. J Isenberg D Hogan M Koss 1986 Human duodenal mucosal bicarbonate secretion. Evidence for basal secretion and stimulation by hydrochloric acid and a synthetic E 1 analogue Gastroenterology 91 370 378 3087810 1:CAS:528:DyaL28XltlWhur8%3D Isenberg J, Hogan D, Koss M, et al.: Human duodenal mucosal bicarbonate secretion. Evidence for basal secretion and stimulation by hydrochloric acid and a synthetic E1 analogue. Gastroenterology 91:370–378, 1986
9. 9. H Odes R Muallem R Reimer 1993 Cholinergic regulation of guinea pig duodenal bicarbonate secretion Am J Physiol 265 G270 G276 8368310 1:CAS:528:DyaK3sXmsVWru7g%3D Odes H, Muallem R, Reimer R, et al.: Cholinergic regulation of guinea pig duodenal bicarbonate secretion. Am J Physiol 265:G270–G276, 1993
10. 10. B Yao D Hogan K Bukhave 1993 Bicarbonate transport by rabbit duodenum in vitro: effect of casoactive intestinal polypeptide, prostaglandin E 2, and cyclic adenosine monophosphate Gastroenterology 104 732 740 8382644 1:CAS:528:DyaK3sXisVyisro%3D Yao B, Hogan D, Bukhave K, et al.: Bicarbonate transport by rabbit duodenum in vitro: effect of casoactive intestinal polypeptide, prostaglandin E2, and cyclic adenosine monophosphate. Gastroenterology 104:732–740, 1993
11. 11. D Hogan B Yao K Barrett 1995 Histamine inhibits prostaglandin E 2 2 receptors and enteric nerves Gastroenterology 108 1676 1682 7768371 1:CAS:528:DyaK2MXmsVKitbk%3D Hogan D, Yao B, Barrett K, et al.: Histamine inhibits prostaglandin E2-stimulated rabbit duodenal bicarbonate secretion via H2 receptors and enteric nerves. Gastroenterology 108:1676–1682, 1995
12. 12. A Mertz-Nielson J Hillingso K Bukhave 1995 Indomethacin decreases gastroduodenal mucosal bicarbonate secretion in humans Scand J Gastroenterol 30 1160 1165 Mertz-Nielson A, Hillingso J, Bukhave K, et al.: Indomethacin decreases gastroduodenal mucosal bicarbonate secretion in humans. Scand J Gastroenterol 30:1160–1165, 1995
13. 13. C Myers D Hogan B Yao 1998 Inhibition of rabbit duodenal bicarbonate by ulcerogenic agents: Histamine-dependent and-independent effects Gastroenterology 114 527 535 9496943 1:CAS:528:DyaK1cXhvVygsrk%3D Myers C, Hogan D, Yao B, et al.: Inhibition of rabbit duodenal bicarbonate by ulcerogenic agents: Histamine-dependent and-independent effects. Gastroenterology 114:527–535, 1998
14. 14. K Bukhave J Rask-Madsen D Hogan 1990 Proximal duodenal prostaglandin E 2 release and mucosal bicarbonate secretion are altered in patients with duodenal ulcer Gastroenterology 99 951 955 2394348 1:STN:280:DyaK3czmsl2gtQ%3D%3D Bukhave K, Rask-Madsen J, Hogan D, et al.: Proximal duodenal prostaglandin E2 release and mucosal bicarbonate secretion are altered in patients with duodenal ulcer. Gastroenterology 99:951–955, 1990
15. 15. J Isenberg J Selling D Hogan 1987 Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer N Engl J Med 316 374 379 10.1056/NEJM198702123160704 3807974 1:STN:280:DyaL2s7hsFKltA%3D%3D Isenberg J, Selling J, Hogan D, et al.: Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. N Engl J Med 316:374–379, 1987
16. 16. D Taylor J Parsonnet 1995 Epidemiology and natural history of H. pylori infections M Blaser P Smith J Ravdin In Infections of the Gastrointestinal Tract Raven New York 551 564 Taylor D, Parsonnet J: Epidemiology and natural history of H. pylori infections. In Infections of the Gastrointestinal Tract. Blaser M, Smith P, Ravdin J, et al. (eds). New York, Raven, 1995, pp 551–564
17. 17. Marshall B: Helicobacter pylori: The etiologic agent for peptic ulcer. JAMA 1064–1066, 1995
18. 18. D Hogan R Rapier A Dreilinger 1996 Duodenal bicarbonate secretion: Eradication of Helicobacter pylori and duodenal structure and function in humans Gastroenterology 110 705 716 8608879 1:CAS:528:DyaK28XhvFCmtLk%3D Hogan D, Rapier R, Dreilinger A, et al.: Duodenal bicarbonate secretion: Eradication of Helicobacter pylori and duodenal structure and function in humans. Gastroenterology 110:705–716, 1996
19. 19. V Pratha D Hogan R Zhou 1999 Helicobacter pylori water extract alters PGE 2 3 − secretion in the human duodenum Gastroenterology 116 A285 Pratha V, Hogan D, Zhou R, et al.: Helicobacter pylori water extract alters PGE2-stimulated HCO3− secretion in the human duodenum. Gastroenterology 116:A285, 1999
20. 20. L Fandriks C Bothmer B Johannon 1997 Water extract of Helicobacter pylori inhibits duodenal mucosal alkaline secretion in anesthetized rats Gastroenterology 113 1570 1575 9352859 1:CAS:528:DyaK2sXnt1Olt74%3D Fandriks L, Bothmer C, Johannon B, et al.: Water extract of Helicobacter pylori inhibits duodenal mucosal alkaline secretion in anesthetized rats. Gastroenterology 113:1570–1575, 1997
21. 21. I Beales M Blaser S Srinivasan 1997 Effect of Helicobacter pylori products and recombinant cytokines on gastrin release from cultured canine G-cells Gastroenterology 113 465 471 9247465 1:CAS:528:DyaK2sXls1Wgu7c%3D Beales I, Blaser M, Srinivasan S, et al.: Effect of Helicobacter pylori products and recombinant cytokines on gastrin release from cultured canine G-cells. Gastroenterology 113:465–471, 1997
22. 22. DL Hogan DL Crombie JI Isenberg 1997 Acid-stimulated duodenal bicarbonate secretion involves a CFTR-mediated transport pathway in mice Gastroenterology 113 533 541 9247473 1:CAS:528:DyaK2sXls1Wnsrk%3D Hogan DL, Crombie DL, Isenberg JI, et al.: Acid-stimulated duodenal bicarbonate secretion involves a CFTR-mediated transport pathway in mice. Gastroenterology 113:533–541, 1997
23. 23. U Seidler I Blumenstein A Kretz 1997 A functional CFTR protein is required for mouse intestinal cAMP-, cGMP-, and Ca 2 + 3 − secretion J Physiol 505 411 423 10.1111/j.1469-7793.1997.411bb.x 9423183 1:CAS:528:DyaK1cXmtFOh Seidler U, Blumenstein I, Kretz A, et al.: A functional CFTR protein is required for mouse intestinal cAMP-, cGMP-, and Ca2 +-dependent HCO3− secretion. J Physiol 505:411–423, 1997
24. 24. C Chew B Safsten 1998 Flemström G: Calcium signaling in cultured human rat duodenal enterocytes Am J Physiol 275 G296 G304 9688657 1:CAS:528:DyaK1cXlsVCktbw%3D Chew C, Safsten B, Flemström G: Calcium signaling in cultured human rat duodenal enterocytes. Am J Physiol 275:G296–G304, 1998
25. 25. K Takeuchi K Yagi S Kato 1997 Roles of prostaglandin E-receptor subtypes in gastric and duodenal bicarbonate secretion in rats Gastroenterology 113 1553 1559 9352857 1:CAS:528:DyaK2sXnt1OlsLY%3D Takeuchi K, Yagi K, Kato S, et al.: Roles of prostaglandin E-receptor subtypes in gastric and duodenal bicarbonate secretion in rats. Gastroenterology 113:1553–1559, 1997
26. 26. K Takeuchi H Ukawa S Kato 1999 Impaired duodenal bicarbonate secretion and mucosal integrity in mice lacking prostaglandin E-receptor subtype EP 3 Gastroenterology 117 1128 1135 10535876 1:CAS:528:DyaK1MXnsVCqtr8%3D Takeuchi K, Ukawa H, Kato S, et al.: Impaired duodenal bicarbonate secretion and mucosal integrity in mice lacking prostaglandin E-receptor subtype EP3. Gastroenterology 117:1128–1135, 1999
27. 27. R Reimer H Odes R Muallem 1994 Cyclic adenosine monophosphate is the second messenger of prostaglandin E 2-and vasoactive intestinal polypeptide-stimulated active bicarbonate secretion by guinea-pig duodenum Scand J Gastroenterol 29 153 159 8171284 1:CAS:528:DyaK2cXivFSntLw%3D Reimer R, Odes H, Muallem R, et al.: Cyclic adenosine monophosphate is the second messenger of prostaglandin E2-and vasoactive intestinal polypeptide-stimulated active bicarbonate secretion by guinea-pig duodenum. Scand J Gastroenterol 29:153–159, 1994
28. 28. A Taha W Fraser R Kelly 1991 Inhibition of human gastric cyclic AMP production by Helicobacter pylori protein-possible involvement of mucosal prostaglandin E 2 Aliment Pharmacol Ther 5 379 389 10.1111/j.1365-2036.1991.tb00041.x 1663793 1:CAS:528:DyaK3MXmt12msL0%3D Taha A, Fraser W, Kelly R, et al.: Inhibition of human gastric cyclic AMP production by Helicobacter pylori protein-possible involvement of mucosal prostaglandin E2. Aliment Pharmacol Ther 5:379–389, 1991
29. 29. S Konturek J Bilski J Tasler 1986 Role of endogenous prostaglandins in duodenal alkaline response to luminal hydrochloric acid or arachidonic acid in conscious dogs Digestion 34 268 274 Konturek S, Bilski J, Tasler J, et al.: Role of endogenous prostaglandins in duodenal alkaline response to luminal hydrochloric acid or arachidonic acid in conscious dogs. Digestion 34(268):274, 1986
30. 30. S Sugamoto S Kawauchi O Furukawa 2001 Role of endogenous nitric oxide and prostaglandin in duodenal bicarbonate response induced by mucosal acidification in rats Dig Dis Sci 46 1208 1216 10.1023/A:1010603026913 11414296 1:CAS:528:DC%2BD3MXkvVOhsLc%3D Sugamoto S, Kawauchi S, Furukawa O, et al.: Role of endogenous nitric oxide and prostaglandin in duodenal bicarbonate response induced by mucosal acidification in rats. Dig Dis Sci 46:1208–1216, 2001
31. 31. L Olbe A Hamlet J Dalenback 1996 A mechanism by which Helicobacter pylori infection of the antrum contributes to the development of duodenal ulcer Gastroenterology 110 1386 1394 8613042 1:CAS:528:DyaK28XjtV2ht7Y%3D Olbe L, Hamlet A, Dalenback J, et al.: A mechanism by which Helicobacter pylori infection of the antrum contributes to the development of duodenal ulcer. Gastroenterology 110:1386–1394, 1996
32. 32. L Olbe L Fandriks A Hamlet 2000 Conceivable mechanisms by which Helicobacter pylori provokes duodenal ulcer disease Bailliere’s Clin Gastroenterol 140 1 12 10.1053/bega.1999.0055 Olbe L, Fandriks L, Hamlet A, et al.: Conceivable mechanisms by which Helicobacter pylori provokes duodenal ulcer disease. Bailliere’s Clin Gastroenterol 140:1–12, 2000
33. 33. R Van-der-Hulst C Tytgat 1996 Helicobacter pylori and peptic ulcer disease Scand J Gastroenterol 220 10 18 1:STN:280:DyaK2s%2FlsVSmsw%3D%3D Van-der-Hulst R, Tytgat C: Helicobacter pylori and peptic ulcer disease. Scand J Gastroenterol 220:10–18, 1996
34. 34. M Walker J Crabtree 1998 Helicobacter pylori infection and the pathogenesis of duodenal ulceration Ann NY Acad Sci 859 96 111 9928373 1:STN:280:DyaK1M7islegtg%3D%3D Walker M, Crabtree J: Helicobacter pylori infection and the pathogenesis of duodenal ulceration. Ann NY Acad Sci 859:96–111, 1998
35. 35. T Cover M Blaser 1999 Helicobacter pylori factors associated with disease Gastroenterology 117 257 261 10381935 1:STN:280:DyaK1MzhsFGktA%3D%3D Cover T, Blaser M: Helicobacter pylori factors associated with disease. Gastroenterology 117:257–261, 1999
36. 36. W Dundon M de-Berbard C Montecucco 2001 Virulence factors of Helicobacter pylori Int J Med Microbiol 290 647 658 11310443 1:CAS:528:DC%2BD3MXjsVWgtbY%3D Dundon W, de-Berbard M, Montecucco C: Virulence factors of Helicobacter pylori. Int J Med Microbiol 290:647–658, 2001
37. 37. W Tee J Lambert B Dwyer 1995 Cytotoxin production by Helicobacter pylori from patients with upper gastrointestinal tract disease J Clin Microbiol 33 1203 1205 7615729 1:STN:280:DyaK2MzktVOntQ%3D%3D Tee W, Lambert J, Dwyer B: Cytotoxin production by Helicobacter pylori from patients with upper gastrointestinal tract disease. J Clin Microbiol 33:1203–1205, 1995
38. 38. A Hamlet A Thoreson O Nilsson 1999 Duodenal Helicobacter pylori infection differs in CagA genotype between asymptomatic subjects and patients with duodenal ulcers Gastroenterology 116 259 268 9922305 1:STN:280:DyaK1M7it12nug%3D%3D Hamlet A, Thoreson A, Nilsson O, et al.: Duodenal Helicobacter pylori infection differs in CagA genotype between asymptomatic subjects and patients with duodenal ulcers. Gastroenterology 116:259–268, 1999
39. 39. D Hogan B Yao J Steinbach 1993 The enteric nervous system modulates mammalian duodenal mucosal bicarbonate secretion Gastroenterology 105 410 417 8335196 1:CAS:528:DyaK3sXmtVSmtr8%3D Hogan D, Yao B, Steinbach J, et al.: The enteric nervous system modulates mammalian duodenal mucosal bicarbonate secretion. Gastroenterology 105:410–417, 1993
40. 40. V Pratha D Hogan B Martenssön 2000 Identification of transport abnormalities in duodenal mucosa and duodenal enterocytes from patients with cystic fibrosis Gastroenterology 118 1051 1060 10833480 1:STN:280:DC%2BD3c3psFSgug%3D%3D Pratha V, Hogan D, Martenssön B, et al.: Identification of transport abnormalities in duodenal mucosa and duodenal enterocytes from patients with cystic fibrosis. Gastroenterology 118:1051–1060, 2000