Correlation of in vitro and in vivo paracetamol availability from layered excipient suppositories

International Journal of Pharmaceutics

Volumn 189, Issue 2, 1999, Pages 147-160

  Chicco, D ^a   Grabnar, I ^a   Skerjanec A ^b   Vojnovic, D ^c   Maurich, V ^c   Realdon, N ^d   Ragazzi, E ^d   Belic A ^a   Karba, R ^a   Mrhar, A ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF TRIESTE   (Italy)

^d UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLGLYCEROL; EXCIPIENT; MONOACYLGLYCEROL; PARACETAMOL; PENETRATION ENHANCING AGENT; WITEPSOL H 15; WITEPSOL W 35;

ADULT; ARTICLE; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG FORMULATION; DRUG RELEASE; DRUG URINE LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; KINETICS; MALE; NORMAL HUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECTAL DRUG ADMINISTRATION; RECTUM; SUPPOSITORY; VISCOSITY; VOLUNTEER;

ACETAMINOPHEN; ADMINISTRATION, RECTAL; ADULT; ANALGESICS, NON-NARCOTIC; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG COMPOUNDING; EXCIPIENTS; FEMALE; HUMANS; MALE; RATS; RATS, WISTAR; RECTUM; STATISTICS; SUPPOSITORIES; TIME FACTORS; VISCOSITY;

EID: 0032856017     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00247-1     Document Type: Article

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