Ispaghula (Plantago ovata) seed husk polysaccharides promote proliferation of human epithelial cells (skin keratinocytes and fibroblasts) via enhanced growth factor receptors and energy production

Planta Medica

Volumn 71, Issue 1, 2005, Pages 33-39

  Deters, A M ^a   Schroder K R ^b   Smiatek, T ^a   Hensel, Andreas ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b HENKEL KGAA   (Germany)

Author keywords

Fibroblasts; Growth factors; Ispaghula; Keratinocytes; KGF; Plantaginaceae; Plantago ovata Forskk.; Polysaccharides; Proliferation; Receptors; Signal transduction

Indexed keywords

ARABINOXYLAN; CARBOHYDRATE; GROWTH FACTOR RECEPTOR; INVOLUCRIN; ISPAGULA; KERATIN K1; KERATIN K10; KERATINOCYTE GROWTH FACTOR; OLIGOSACCHARIDE; POLYSACCHARIDE; RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL FUNCTION; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; ENERGY YIELD; EPITHELIUM CELL; FERTILIZATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; KERATINOCYTE; PLANTAGO OVATA; RNA ANALYSIS; SEED HUSK; SIGNAL TRANSDUCTION; SKIN FIBROBLAST;

CELL LINE; CELL PROLIFERATION; DNA PRIMERS; EPITHELIAL CELLS; FIBROBLASTS; HUMANS; KERATINOCYTES; KERATOLYTIC AGENTS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTAGO; POLYSACCHARIDES; RECEPTORS, GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEEDS; SKIN;

EID: 13544267542     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-837748     Document Type: Article

References (20)

1. Brunold C, Deters A, Knoepfl-Sidler F, Hafner J, Müller B, Hensel A. Polysaccharides from Hibiscus sabdariffa flowers stimulate proliferation and differentiation of human keratinocytes. Planta Medica 2004; 70: 370-3
2. Hensel A, Frank B, Hose S. Indische Flohsamenschalen - eine alte Droge für moderne Zivilisationserkrankungen. Zt Phytother, 2001: 309-21
3. Green H. The keratinocyte as differentiated cell type. The Harvey Lectures 1979; 74: 101-39
4. Mitev V, Miteva L. Signal transduction in keratinocytes. Exp Dermatol 1999; 8: 96-108
5. Monsigny M, Petit C, Roche A-C. Colorimetric determination of neutral sugars by a resorcinol sulfuric acid micromethod. Anal Biochem 1988; 175: 525-30
6. Blumenkrantz N, Asboe-Hansen G. New method for quantitative determination of uronic acids. Anal Biochem 1973; 54: 484-9
7. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-53
8. Blakeney AB, Harris PJ, Henry RJ, Stone BA. A simple and rapid preparation of alditol acetates for monosaccharide analysis. Carbohydr Res 1983; 113: 291-9
9. Taylor RT, Conrad HE. Stochiometric depolymerization of polyuronides and glucosaminoglycanes to monosaccharides following reduction of their carbodiimide-activated carboxyl groups. Biochemistry 1972; 11: 1383-8
10. Mosmann M. Rapid colorimetric assay for cellular growth and survival: applications to proliferation and cytotoxicity assays. J Immun Meth 1983; 65: 55-63
11. Rechia CG, Sierakowski MR, Ganter JL, Reicher F. Polysaccharides from the seeds of Senna multijuga. Int J Biol Macromol 1995; 17: 409-12
12. Deters A, Dauer A, Schnetz E, Fartasch M, Hensel A. High-molecular products (proanthocyanidins and polysaccharides) from Hamamelis bark: influence on human keratinocyte proliferation and differentiation. Phytochemistry 2001; 58: 949-58
13. Ebringerova A, Kardosova A, Hromadkova Z, Malovikova A, Hribalova V. Immunomodulatory activity of acidic xylans in relation to their structural and molecular properties. Int J Biol Macromol 2002; 30: 1-6
14. Deters A, Schröder K, Hensel A. Kiwi fruit (Actinidia chinensis L.) polysaccharides exert stimulating effects on cell proliferation via growth factor receptors, energy production and collagen synthesis of human keratinocytes, fibroblasts and skin equivalents. J Cell Physiol, 2004; published online: DOI: 10.1002/jcp.20161
15. Kawada A, Hiura N, Shiraiwa M, Tajima S, Hiruma M, Hara K, Ishibashi A, Takahara H. Stimulation of human keratinocyte growth by alginate oligosaccharides, a possible co-factor for epidermal growth factor in cell culture. FEBS Lett 1997; 408: 43-6
16. 3 enhances the calcium response of keratinocytes. J Cell Physiol 1999; 178: 188-96
17. Takahashi H, Aoki N, Nakamura S, Asano K, Ishida-Yamamoto A, Iizuka H. Cornified cell envelope formation is distinct from apoptosis in epidermal keratinocytes. J Dermatol Sci 2000; 23: 161-9
18. Marlett JA, Fischer MH. The active fraction of Psyllium seed husk. Proc Nutr Soc 2003; 62: 207-9
19. Edwards S, Chaplin MF, Blackwood AD, Dettmar PW. Primary structure of arabinoxylans of ispaghula husk and wheat bran. Proc Nutr Soc 2003; 62: 217-22
20. Yabe T, Huang CC. Effect of lipoteichoic acid on proliferation and differentiation of keratinocytes. Otholaryngol Head Nech Surg 1989; 101: 646-50