Two autoimmune diabetes loci influencing T cell apoptosis control susceptibility to experimental autoimmune myocarditis

Journal of Immunology

Volumn 174, Issue 4, 2005, Pages 2167-2173

  Guler, Mehmet L ^a   Ligons, Davinna L ^a   Wang, Yan ^a   Bianco, Michael ^a   Broman, Karl W ^b   Rose, Noel K ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; DEXAMETHASONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CHROMOSOME 1; CHROMOSOME 6; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE PREDISPOSITION; FEMALE; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; MALE; MOUSE; MYOCARDITIS; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

EID: 13544263580     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.4.2167     Document Type: Article

References (33)

1. Brown, C. A., and J. B. O'Connell. 1995. Myocarditis and idiopathic dilated cardiomyopathy. Am. J. Med. 99:309.
2. Drory, Y., Y. Turetz, Y. Hiss, B. Lev, E. Z. Fisman, A. Pines, and M. R. Kramer. 1991. Sudden unexpected death in persons less than 40 years of age. Am. J. Cardiol. 68:1388.
3. Felker, G. M., W. Hu, J. M. Hare, R. H. Hruban, K. L. Baughman, and E. K. Kasper. 1999. The spectrum of dilated cardiomyopathy: The Johns Hopkins experience with 1,278 patients. Medicine 78:270.
4. Rose, N. R., A. Herskowitz, D. A. Neumann, and N. Neu. 1988. Autoimmune myocarditis: a paradigm of post-infection autoimmune disease. Immunol. Today 9:117.
5. Rose, N. R., L. J. Wolfgram, A. Herskowitz, and K. W. Beisel. 1986. Postinfectious autoimmunity: two distinct phases of coxsackievirus B3-induced myocarditis. Ann. NY Acad. Sci. 475:146.
6. Caforio, A. L., J. H. Goldman, A. J. Haven, K. M. Baig, L. D. Libera, and W. J. McKenna. 1997. Circulating cardiac-specific autoantibodies as markers of autoimmunity in clinical and biopsy-proven myocarditis: The Myocarditis Treatment Trial Investigators. Eur. Heart J. 18:270.
7. Caforio, A. L., J. H. Goldman, A. J. Haven, K. M. Baig, and W. J. McKenna. 1996. Evidence for autoimmunity to myosin and other heart-specific autoantigens in patients with dilated cardiomyopathy and their relatives. Int. J. Cardiol. 54:157.
8. Wolfgram, L. J., K. W. Beisel, and N. R. Rose. 1985. Heart-specific autoantibodies following murine coxsackievirus B3 myocarditis. J. Exp. Med. 161:1112.
9. Neu, N., K. W. Beisel, M. D. Traystman, N. R. Rose, and S. W. Craig. 1987. Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to coxsackievirus B3-induced myocarditis. J. Immunol. 138:2488.
10. Neu, N., N. R. Rose, K. W. Beisel, A. Herskowitz, G. Gurri Glass, and S. W. Craig. 1987. Cardiac myosin induces myocarditis in genetically predisposed mice. J. Immunol. 139:3630.
11. Smith, S. C., and P. M. Allen. 1991. Myosin-induced acute myocarditis is a T cell-mediated disease. J. Immunol. 147:2141.
12. Smith, S. C., and P. M. Allen. 1993. The role of T cells in myosin-induced autoimmune myocarditis. Clin. Immunol. Immunopathol. 68:100.
13. Wolfgram, L. J., K. W. Beisel, A. Herskowitz, and N. R. Rose. 1986. Variations in the susceptibility to coxsackievirus B3-induced myocarditis among different strains of mice. J. Immunol. 136:1846.
14. Traystman, M. D., and K. W. Beisel. 1991. Genetic control of coxsackievirus B3-induced heart-specific autoantibodies associated with chronic myocarditis. Clin. Exp. Immunol. 86:291.
15. Neu, N., S. W. Craig, N. R. Rose, F. Alvarez, and K. W. Beisel. 1987. Coxsackievirus induced myocarditis in mice: cardiac myosin autoantibodies do not cross-react with the virus. Clin. Exp. Immunol. 69:566.
16. Gorham, J. D., M. L. Guler, R. G. Steen, A. J. Mackey, M. J. Daly, K. Frederick, W. F. Dietrich, and K. M. Murphy. 1996. Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses. Proc. Natl. Acad. Sci. USA 93:12467.
17. Broman, K. W., H. Wu, S. Sen, and G. A. Churchill. 2003. R/qtl; QTL mapping in experimental crosses. Bioinformatics 19:889.
18. Ihaka, R., and R. Gentleman. 1996. R: a language for data analysis and graphics. J. Comput. Graph. Stat. 5:299.
19. Xu, S., and W. R. Atchley. 1996. Mapping quantitative trait loci for complex binary diseases using line crosses. Genetics 143:1417.
20. Churchill, G. A., and R. W. Doerge. 1994. Empirical threshold values for quantitative trait mapping. Genetics 138:963.
21. Sen, S., and G. A. Churchill. 2001. A statistical framework for quantitative trait mapping. Genetics 159:371.
22. Bergman, M. L., N. Duarte, S. Campino, M. Lundholm, V. Motta, K. Lejon, C. Penha-Goncalves, and D. Holmberg. 2003. Diabetes protection and restoration of thymocyte apoptosis in NOD Idd6 congenic strains. Diabetes 52:1677.
23. Colucci, F., M. L. Bergman, C. Penha-Goncalves, C. M. Cilio, and D. Holmberg. 1997. Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region. Proc. Natl. Acad. Sci. USA 94:8670.
24. Rose, N. R., D. A. Neumann, A. Herskowitz, M. D. Traystman, and K. W. Beisel. 1988. Genetics of susceptibility to viral myocarditis in mice. Pathol. Immunopathol. Res. 7:266.
25. Beisel, K. W., L. Wolfgram, A. Hershkowitz, and N. R. Rose. 1985. Differences in severity of coxsackievirus B3-induced myocarditis among H-2 congenic strains. In Genetic Control of Host Resistance to Infection and Malignancy. E. Skamane, ed. Liss, New York, p. 195.
26. Dupuis, J., and D. Siegmund. 1999. Statistical methods for mapping quantitative trait loci from a dense set of markers. Genetics 151:373.
27. Wicker, L. S., J. A. Todd, and L. B. Peterson. 1995. Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13:179.
28. Vyse, T. J., and J. A. Todd. 1996. Genetic analysis of autoimmune disease. Cell 85:311.
29. Penha-Goncalves, C., K. Leijon, L. Persson, and D. Holmberg. 1995. Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6. Genomics 28:398.
30. Chang, T. T., V. K. Kuchroo, and A. H. Sharpe. 2002. Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. Curr. Dir. Autoimmun. 5:113.
31. Kristiansen, O. P., Z. M. Larsen, and F. Pociot. 2000. CTLA-4 in autoimmune diseases - a general susceptibility gene to autoimmunity? Genes Immun. 1:170.
32. Ueda, H., J. M. Howson, L. Esposito, J. Heward, H. Snook, G. Chamberlain, D. B. Rainbow, K. M. Hunter, A. N. Smith, G. Di Genova, et al. 2003. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423:506.
33. Bergman, M. L., C. Penha-Goncalves, K. Lejon, and D. Holmberg. 2001. Low rate of proliferation in immature thymocytes of the non-obese diabetic mouse maps to the Idd6 diabetes susceptibility region. Diabetologia 44:1054.