Solid-phase synthesis of fungitoxic 2-imino-1,3-thiazolines

Journal of Combinatorial Chemistry

Volumn 7, Issue 1, 2005, Pages 7-9

  Bae, Suyeal ^a   Hahn, Hoh Gyu ^a   Nam, Kee Dal ^a   Mah, Heduck ^b  

^a Korea Institute of Science and Technology   (South Korea)

^b Kyonggi University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AGRICULTURAL CHEMICAL; FUNGICIDE; THIAZOLE DERIVATIVE;

ACIDITY; ANTIFUNGAL ACTIVITY; ARTICLE; COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; DEGRADATION; DEGRADATION KINETICS; FUNGICIDAL ACTIVITY; REACTION ANALYSIS; SOLID PHASE SYNTHESIS;

ANTIFUNGAL AGENTS; IMINES; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; THIAZOLES;

EID: 13544260731     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc049854w     Document Type: Article

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22. 3CN (from 8:2 to 3:7), with a flow rate of 2.0 mL/min and UV absorbance at 220 and 254 nm.
23. +).
24. 2 in DCM solution, this solution (800 μmol, 0.585 mmol) was added slowly, and the reactor was shaken for 1.5 h at -10°C. The resin was washed with DCM (3 mL x 2), MeOH (3 mL x 2), and DCM (3 mL x 2) and then dried under vacuum for 3 h. DMF/thiourea 8 (1 mL/0.32 mmol) was added to the reactor, and the reactor was shaken for 12 h at 80°C. The resin was washed with DMF (3 mL x 2), MeOH (3 mL x 2), and DCM (3 mL x 2) and then dried under vacuum for 2 h. Finally, the resin was treated with 50% TFA/DCM for 30 min, from which the reaction mixture was filtered and concentrated within a Genevac model HT-4 evaporator.