Addition of benzylic and allylic organozinc and grignard reagents to resin-bound imines to provide α-branched secondary amines bearing a wide variety of functional groups. Utility in the synthesis of β-3 adrenergic receptor agonists

Journal of Combinatorial Chemistry

Volumn 7, Issue 1, 2005, Pages 99-108

  Wu, Gang ^a   Cai, Zhen Wei ^a   Bednarz, Mark S ^a   Kocy, Octavian R ^a   Gavai, Ashvinikumar V ^a   Godfrey Jr , Jollie D ^a   Washburn, William N ^a   Poss, Michael A ^a   Sher, Philip M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL COMPOUND; AMINE; BENZYL DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; ORGANOMETALLIC COMPOUND; RESIN;

ALLYLATION; AROMATIZATION; ARTICLE; BENZYLATION; COMBINATORIAL LIBRARY; DRUG DESIGN; DRUG SYNTHESIS; GRIGNARD REACTION; REACTION ANALYSIS;

ADRENERGIC BETA-AGONISTS; AMINES; BENZENE; COMBINATORIAL CHEMISTRY TECHNIQUES; IMINES; MOLECULAR STRUCTURE; RECEPTORS, ADRENERGIC, BETA-3; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 13544251631     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc0498682     Document Type: Article

References (37)

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