Pharmacokinetics of a novel antiangiogenic agent KR-31831 in rats

Biopharmaceutics and Drug Disposition

Volumn 26, Issue 1, 2005, Pages 21-26

  Kim, Sook J ^a   Lee, Hong I ^a   Ji, Hye Y ^a   Moon, Ya ^a   Paek, In B ^a   Lee, Sunkyung ^b   Yi, Kyu Y ^b   Yoo, Sun D ^c   Lee, Hye S ^a  

^a Wonkwang University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

Antiangiogenesis; Bioavailability; KR 31831; Pharmacokinetics

Indexed keywords

6 AMINO 4 [[N (4 CHLOROPHENYL) N (2 METHYL 2H TETRAZOL 5 YLMETHYL)AMINO] 3,4 DIHYDRO 2 DIMETHOXYMETHYL 3 HYDROXY 2 METHYL 2H 1 BENZOPYRAN]; ANGIOGENESIS INHIBITOR; KR 31831; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG URINE LEVEL; LIQUID CHROMATOGRAPHY; LIVER MICROSOME METABOLISM; LOW DRUG DOSE; MALE; MASS SPECTROMETRY; NONHUMAN; PLASMA PROTEIN BINDING; RAT; STATISTICAL SIGNIFICANCE; STRUCTURE ANALYSIS; URINARY EXCRETION;

ADMINISTRATION, ORAL; ANGIOGENESIS INHIBITORS; ANIMALS; AREA UNDER CURVE; BENZOPYRANS; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; INJECTIONS, INTRAVENOUS; MEN; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 13444309689     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.427     Document Type: Article

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