Determination of a Novel Antiangiogenic Agent KR-31831 in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry

Analytical Letters

Volumn 37, Issue 2, 2004, Pages 283-292

  Kim, Sook Jin ^a   Lee, Seung Seok ^a   Ji, Hye Young ^a   Lee, Hong Il ^a   Lee, Seonkyoung ^b   Yi, Kyu Yang ^b   Yoo, Seong Eun ^b   Hwang, Jeongsug ^c   Lee, Hye Suk ^a  

^a Wonkwang University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Daejeon University   (South Korea)

Author keywords

Angiogenesis; KR 31831; LC MS MS; Plasma

Indexed keywords

ACETONITRILE; AMMONIUM FORMATE; ANGIOGENESIS INHIBITOR; DICHLOROMETHANE; KR 31543; KR 31831; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; PH; TANDEM MASS SPECTROMETRY;

EID: 1542285938     PISSN: 00032719     EISSN: None     Source Type: Journal    
DOI: 10.1081/AL-120027793     Document Type: Article

References (3)

1. Semenza, G.L. Angiogenesis in ischemic and neoplastic disorders. Annu. Rev. Med. 2003, 54, 17-28.
2. Kim, N.; Lee, S.; Yi, K.Y.; Yoo, S.; Kim, G.; Lee, C.O.; Park, S.H. Identification of a novel antiangiogenic agent: 4-(N-imidazol-2-ylmethyl) aminobenzopyran analogues. Bioorg. Med. Chem. Lett. 2003, 13, 1661-1663.
3. Guidance for Industry-Bioanalytical Method Validation; US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Center for Veterinary Medicine, May 2001; http://www.fda.gov/cder/guidance/index.htm.