Effect of granulocyte-macrophage colony-stimulating factor on post-weaning multisystemic wasting syndrome in porcine circovirus type-2-transfected piglets

International Journal of Experimental Pathology

Volumn 86, Issue 1, 2005, Pages 33-43

  Loizel, Christophe ^a   Blanchard, Philippe ^a   Grasland, Béatrice ^a   Dory, Daniel ^a   Oger, Aurélie ^a   Nignol, Anne Cécile ^a   Cariolet, Roland ^a   Jestin, André ^a  

^a Healthy Pigs Production and Experimentation Section   (France)

Author keywords

GM CSF; In vivo transfection; Infectious DNA; Intramuscular route; PCV2; PMWS

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; VIRULENCE FACTOR; VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCOVIRIDAE; CONTROLLED STUDY; DNA TRANSFECTION; GENETIC TRANSDUCTION; HOST; IMMUNE SYSTEM; IMMUNOSTIMULATION; MOLECULAR CLONING; NONHUMAN; PATHOGENESIS; PLASMID; PORCINE CIRCOVIRUS TYPE 2; POST WEANING MULTISYSTEMIC WASTING SYNDROME; PRIORITY JOURNAL; SWINE; SWINE DISEASE; TISSUE DISTRIBUTION; VIRUS DETECTION; VIRUS GENOME; VIRUS INFECTION; VIRUS LOAD; VIRUS REPLICATION; VIRUS VIRULENCE; WASTING SYNDROME;

ANIMALS; CIRCOVIRIDAE INFECTIONS; CIRCOVIRUS; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENETIC VECTORS; GENOME, VIRAL; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; LYMPH NODES; PLASMIDS; POLYMERASE CHAIN REACTION; SWINE; SWINE DISEASES; TRANSFECTION; WASTING SYNDROME; WEANING;

EID: 13444304126     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0959-9673.2005.00409.x     Document Type: Article

References (57)

1. Ahmed S.A., Gogal R.M., Walsh J.E. (1994) A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay. J. Immunol. Methods 170, 211-224.
2. Albina E., Cariolet R., Eveno E. (1996) Premiers résultats du CNEVA sur le dépérissement fatal du porcelet en fin de post-sevrage. Suppl. Sem. Vet. 834, 1-2.
3. Albina E., Truong C., Hutet E. et al. (2001) An experimental model for post-weaning multisystemic wasting syndrome (PMWS) in growing piglets. J. Comp. Pathol. 125, 292-303.
4. Allan G.M., McNeilly F., Kennedy S. et al. (1998) Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe. J. Vet. Diagn. Invest. 10, 3-10.
5. Allan G.M., McNeilly F., Kennedy S., Meehan B., Ellis J., Krakowka S. (2000) Immunostimulation, PCV-2 and PMWS. Vet. Rec. 147, 170-171.
6. Balasch M., Segales J., Resell C. et al (1999) Experimental inoculation of conventional pigs with tissue homogenates from pigs with post-weaning multisystemic wasting syndrome. J. Comp. Pathol. 121, 139-148.
7. Blanchard P., Loizel C., Baudouard M.A. et al. (2004) Quantification du génome du circovirus porcin de type 2 (PCV2) par PCR en temps réel et corrélation avec la maladie d'amaigrissement du porcelet (MAP). Journées de la Recherche Porcine 36, 327-332.
8. Blanchard P., Mahe D., Cariolet R. et al. (2003a) Protection of swine against post-weaning multisystemic wasting syndrome (PMWS) by porcine circovirus type 2 (PCV2) proteins. Vaccine 21, 4565-4575.
9. Blanchard P., Mahe D., Cariolet R. et al. (2003b) An ORF2 protein-based ELISA for porcine circovirus type 2 antibodies in post-weaning multisystemic wasting syndrome. Vet. Microbiol. 94, 183-194.
10. de Boisseson C., Beven V., Bigarre L. et al. (2004) Molecular characterization of porcine circovirus type 2 isolates from post-weaning multisystemic wasting syndrome-affected and non-affected pigs. J. Gen. Virol. 85, 293-304.
11. Cariolet R., Marie P., Moreau G., Robert H. (1994) Summary of the different methods for producing, maintaining and benefitting from piglets of high health status. Journée de la Recherche Porcine en France 26, 1-12.
12. Choi C. & Chae C. (2000) Distribution of porcine parvovirus in porcine circovirus 2-infected pigs with postweaning multisystemic wasting syndrome as shown by in situ hybridization. J. Comp. Pathol. 123, 302-305.
13. Clark E. (1997) Post-weaning multisystemic wasting syndrome. Proceedings of the American Association of Swine Practitioners, 499-501.
14. Corley M.M. & Giambrone J.J. (2002) Immunosuppression in specific-pathogen-free broilers administered infectious bursal disease virus vaccines by in ovo route. Avian. Dis. 46, 810-815.
15. Daft B., Nordhausen R.W., Latimer K.S., Niagro F.D. (1996) Interstitial pneumonia and lymphadenopathy associated with circoviral infection in a six week-old pig. Proc. Am Assioc Vet Lab Diagn 39, 32.
16. Dufour V., Chevallier S., Cariolet R. et al. (2000) Induction of porcine cytokine mRNA expression after DNA immunization and pseudorabies virus infection. J. Interferon Cytokine Res. 20, 889-895.
17. Ellis J., Hassard L., Clark E. et al. (1998) Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome. Can. Vet. J. 39, 44-51.
18. Ellis J., Krakowka S., Lairmore M. et al. (1999) Reproduction of lesions of postweaning multisystemic wasting syndrome in gnotobiotic piglets. J. Vet. Diagn. Invest. 11, 3-14.
19. Fenaux M., Halbur P.G., Gill M., Toth T.E., Meng X.J. (2000) Genetic characterization of type 2 porcine circovirus (PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2. J. Clin. Microbiol 38, 2494-2503.
20. Fenaux M., Halbur P.G., Haqshenas G. et al. (2002) Cloned genomic DNA of type 2 porcine circovirus is infectious when injected directly into the liver and lymph nodes of pigs: characterization of clinical disease, virus distribution, and pathologic lesions. J. Virol. 76, 541-551.
21. Fenaux M., Opriessnig T., Halbur P.G., Elvinger F., Meng X.J. (2004) A chimeric porcine circovirus (PCV) with the immunogenic capsid gene of the pathogenic PCV type 2 (PCV2) cloned into the genomic backbone of the nonpathogenic PCV1 induces protective immunity against PCV2 infection in pigs. J. Virol. 78, 6297-6303.
22. Flo J., Beatriz Perez A., Tisminetzky S., Baralle F. (2000) Superiority of intramuscular route and full length glycoprotein D for DNA vaccination against herpes simplex 2. Enhancement of protection by the co-delivery of the GM-CSF gene. Vaccine 18, 3242-3253.
23. Gerloni M., Lo D., Ballou W.R., Zanetti M. (1998) Immunological memory after somatic transgene immunization is positively affected by priming with GM-CSF and does not require bone marrow-derived dendritic cells. Eur. J. Immunol. 28, 1832-1838.
24. Gilpin D.F., McCullough K., Meehan B.M. et al. (2003) In vitro studies on the infection and replication of porcine circovirus type 2 in cells of the porcine immune system. Vet. Immunol. Immunopathol. 94, 149-161.
25. Gilpin D., Stevenson L.S., McCullough K. et al. (2001) Studies on the in vitro and vivo effect of porcine circovirus type 2 in cells of porcine monocytic cells. In: Proceedings of the Ss DNA Viruses of Plants, Birds, Pigs and Primates, pp. 97. St Malo, France: ISPAIA.
26. Gogal R.M., Ahmed S.A., Larsen C.T. (1997) Analysis of avian lymphocyte proliferation by a new, simple, nonradioactive assay (lympho-pro). Avian Dis. 41, 714-725.
27. Grasland B., Blanchard P., Loizel C. et al. (2004) Experimental reproduction of PMWS in immuno-stimulated SPF piglets infected with cloned genomic DNA of type-2 porcine circovirus. In: 18th International Pig Veterinary Society Congress. Germany: Hamburg.
28. Harding J. (1997a) Post-weaning multisystemic wasting syndrome (PMWS): preliminary epidemiology and clinical presentation. Proceedings of the American Association of Swine Practitioners, 503.
29. Harding J.C.E. (1997b) Recognizing and diagnosing post-weaning wasting syndrome (PMWS). Swine Health Prod. 5, 201-203.
30. Hoogland M., Opriessnig T., Meng X.J., Halbur P. (2004) Effect of commonly used bacterin adjuvants on PCV-2 associated lesions. In: 18th international Pig Veterinary Society Congress. Germany: Hamburg.
31. Kaerber G. (1931) Beitrag zur kollektiven Behandlung pharmakologiscer. Archiv Fuer Pharmakologie und Experimentelle Pathologie 162, 480-483.
32. Kennedy S., Moffett D., McNeilly F et al (2000) Reproduction of lesions of postweaning multisystemic wasting syndrome by infection of conventional pigs with porcine circovirus type 2 alone or in combination with porcine parvovirus. J. Comp. Pathol. 122, 9-24.
33. Kitamura T., Tange T., Terasawa T. et al. (1989) Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J. Cell Physiol. 140, 323-334.
34. Krakowka S., Ellis J.A., McNeilly F., Ringler S., Rings D.M., Allan G. (2001) Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2). Vet. Pathol. 38, 31-42.
35. Krakowka S., Ellis J.A., Meehan B., Kennedy S., McNeilly F., Allan G. (2000) Viral wasting syndrome of swine: experimental reproduction of postweaning multisystemic wasting syndrome in gnotobiotic swine by coinfection with porcine circovirus 2 and porcine parvovirus. Vet. Pathol. 37, 254-263.
36. Kusakabe K., Xin K.Q., Katoh H. et al. (2000) The timing of GM-CSF expression plasmid administration influences the Th1/Th2 response induced by an HIV-1-specific DNA vaccine. J. Immunol. 164, 3102-3111.
37. Kyriakis S.C., Saoulidis, K., Lekkas S., Miliotis Ch C., Papoutsis P.A., Kennedy S. (2002) The effects of immuno-modulation on the clinical and pathological expression of postweaning multisystemic wasting syndrome. J. Comp. Pathol. 126, 38-46.
38. Ladekjaer-Mikkelsen A.S., Nielsen J., Stadejek T. et al. (2002) Reproduction of postweaning multisystemic wasting syndrome (PMWS) in immunostimulated and non-immunostimulated 3-week-old piglets experimentally infected with porcine circovirus type 2 (PCV2). Vet. Microbiol. 89, 97-114.
39. LeCann P., Albina E., Madec F., Cariolet R., Jestin A. (1997) Piglet wasting disease. Vet. Rec. 141, 660.
40. Magar R., Larochelle R., Thibault S., Lamontagne L. (2000) Experimental transmission of porcine circovirus type 2 (PCV2) in weaned pigs: a sequential study. J. Comp. Pathol. 123, 258-269.
41. McNeilly F., Allan G.M., Foster J.C., Adair B.M., McNutty M.S., Pollock J. (1996) Effect of porcine circovirus infection on porcine alveolar macrophage function. Vet. Immunol. Immunopathol. 49, 295-306.
42. Meehan B., Gilpin D., Krakowa S., Ellis J., McNeilly F., Allan G. (2001) In vivo quantification analyses of PCV2 DNAs: correlation of virus load measurements with disease reproduction. Proceedings of the ssDNA Viruses of Plants, Birds, Pigs and Primates. p 103. France: St Malo.
43. Meehan B.M., McNeilly F., Todd D. et al. (1998) Characterization of novel circovirus DNAs associated with wasting syndromes in pigs. J. Gen. Virol. 79, 2171-2179.
44. Morozov I., Sirinarumitr T., Sorden S.D. et al. (1998) Detection of a novel strain of porcine circovirus in pigs with postweaning multisystemic wasting syndrome. J. Clin. Microbiol. 36, 2535-2541.
45. Olvera A., Sibila M., Calsamiglia M., Segales J., Domingo M. (2004) Comparison of porcine circovirus type 2 load in serum quantified by a real time PCR in postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome naturally affected pigs. J. Virol. Methods 117, 75-80.
46. Opriessnig T., Fenaux M., Yu S. et al. (2004) Effect of porcine parvovirus vaccination on the development of PMWS in segregated early weaned pigs coinfected with type 2 porcine circovirus and porcine parvovirus. Vet. Microbiol. 98, 209-220.
47. Quintana J., Segales J., Rosell C. et al. (2001) Clinical and pathological observations on pigs with postweaning multisystemic wasting syndrome. Vet. Rec. 149, 357-361.
48. Resendes A., Segales J., Balasch M. et al. (2004) Lack of an effect of a commercial vaccine adjuvant on the development of postweaning multisystemic wasting syndrome (PMWS) in porcine circovirus type 2 (PCV2) experimentally infected conventional pigs. Vet. Res. 35, 83-90.
49. Roca M., Balasch M., Segales J. et al. (2004) In vitro and in vivo characterization of an infectious clone of a European strain of porcine circovirus type 2. J. Gen. Virol. 85, 1259-1266.
50. Rosell C., Segales J., Domingo M. (2000) Hepatitis and staging of hepatic damage in pigs naturally infected with porcine circovirus type 2. Vet. Pathol. 37, 687-692.
51. Rosell C., Segales J., Plana-Duran J. et al. (1999) Pathological, immunohistochemical, and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs. J. Comp. Pathol. 120, 59-78.
52. Rovira A., Balasch M., Segales J. et al (2002) Experimental inoculation of conventional pigs with porcine reproductive and respiratory syndrome virus and porcine circovirus 2. J. Virol. 76, 3232-3239.
53. Scheerlinck J.Y. (2001) Genetic adjuvants for DNA vaccines. Vaccine 19, 2647-2656.
54. Segales J., Sitjar M., Domingo M. et al. (1997) First report of post-weaning multisystemic wasting syndrome in pigs in Spain. Vet. Rec. 141, 600-601.
55. Sibila M., Olvera A., Calsamiglia M., Segales J., Domingo M. (2003) Quantification of PCV2 load by real time PCR in PMWS and PDNS naturally affected pigs. In: Proceedings for the 4th International Symposium on Emerging and Re-Emerging Pig Diseases. pp. 207-208. Italy: Rome.
56. Somasundaram C., Takamatsu H., Andreoni C. et al. (1999) Enhanced protective response and immuno-adjuvant effects of porcine GM-CSF on DNA vaccination of pigs against Aujeszky's disease virus. Vet. Immunol. Immunopathol. 70, 277-287.
57. Tischer I., Peters D., Rasch R., Pociuli S. (1987) Replication of porcine circovirus: induction by glucosamine and cell cycle dependence. Arch. Virol. 96, 39-57.