Overexpression of the human interleukin 1α gene causes osteopenia in mice

Journal of Rheumatology

Volumn 32, Issue 2, 2005, Pages 320-324

  Aoki, Yoshihiro ^a   Ichimura, Shoichi ^a   Kikuchi, Toshiyuki ^a   Yoshihara, Yasuo ^a   Kogawa, Masakazu ^a   Tada, Norihiro ^b   Nemoto, Koichi ^a   Fujikawa, Kyosuke ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

Interleukin 1; Osteopenia; Rheumatoid arthritis; Transgenic mice

Indexed keywords

ALKALINE PHOSPHATASE; INTERLEUKIN 1; INTERLEUKIN 1ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MINERALIZATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; ENZYME BLOOD LEVEL; FEMUR; GENE OVEREXPRESSION; HUMAN; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; OSTEOPENIA; PRIORITY JOURNAL; SPECIES COMPARISON; TRABECULAR BONE; TRANSGENIC MOUSE; WILD TYPE;

ALKALINE PHOSPHATASE; ANIMALS; ARTHRITIS, RHEUMATOID; BONE DENSITY; BONE DISEASES, METABOLIC; CALCIUM; DISEASE MODELS, ANIMAL; FEMUR; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-1; MICE; MICE, TRANSGENIC; TOMOGRAPHY, X-RAY COMPUTED;

EID: 13444283328     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Hooyman JR, Melton LJ III, Nelson AM, O'Fallon WM, Riggs BL. Fractures after rheumatoid arthritis: a population-based study. Arthritis Rheum 1984;27:1353-7.
2. Michel BA, Bloch DA, Wolfe F, Fries JF. Fractures in rheumatoid arthritis: an evaluation of associated risk factors. J Rheumatol 1993;20:1666-9.
3. Spector TD, Hall GM, McCloskey EV, Kanis JA. Risk of vertebral fractures in women with rheumatoid arthritis. BMJ 1993;306:558.
4. Cooper C, Coupland C, Mitchel M. Rheumatoid arthritis, corticosteroid therapy, and hip fracture. Ann Rheum Dis 1995;54:49-52.
5. Laan RF, van Riel PL, van de Putte LB. Bone mass in patients with rheumatoid arthritis. Ann Rheum Dis 1992;51:826-32.
6. Gough AK, Lilley J, Eyre S, Holder RL, Emery P. Generalized bone loss in patients with early rheumatoid arthritis. Lancet 1994;344:23-7.
7. Gravallese EM, Goldring SR. Cellular mechanisms and the role of cytokines in bone erosions in rheumatoid arthritis. Arthritis Rheum 2000;43:2143-51.
8. Arend WP, Dayer J. Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. Arthritis Rheum 1990;33:305-15.
9. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996;87:2095-147.
10. Eastgate JA, Symons JA, Nigel CW, et al. Correlation of plasma interleukin 1 levels and disease activity in rheumatoid arthritis. Lancet 1988;2:706-9.
11. Peck WA, Woods WL. The cells of bone. In: Riggs BL, Melton LJ III, editors. Osteoporosis: etiology, diagnosis, and management. New York: Raven Press; 1988:1-44.
12. Boyce BF, Aufdemorte TB, Garrett IR, Yates AJ, Mundy GR. Effects of interleukin-1 on bone turnover in normal mice. Endocrinology 1989;125:1142-50.
13. Sabatini M, Boyce B, Aufdemorte T, Bonewald L, Mundy GR. Infusions of recombinant human interleukins 1α and 1β cause hypercalcemia in normal mice. Proc Natl Acad Sci USA 1988;85:5235-9.
14. Morony S, Capparelli C, Lee R, et al. A chimeric form of osteoprotegerin inhibits hypercalcemia and bone resorption induced by IL-1β, TNF-α, PTH, PTHrP, and 1,25(OH)2D3. J Bone Miner Res 1999;14:1478-85.
15. Niki Y, Yamada H, Seki S, et al. Macrophage- and neutrophil-dominant arthritis in human IL-1α transgenic mice. J Clin Invest 2001;107:1127-35.
16. Parfitt AM, Drezner MK, Gloroeux FH, et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. J Bone Miner Res 1987;2:595-610.
17. Miyamoto T, Ohneda O, Arai F, et al. Bifurcation of osteoclasts and dendritic cells from common progenitors. Blood 2001;98:2544-54.
18. Jimi E, Nakamura I, Duong LT, et al. Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells. Exp Cell Res 1999;247:84-93.
19. Kobayashi K, Takahashi N, Jimi E, et al. Tumor necrosis factor α stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med 2000;191:275-85.
20. Werman A, Werman-Venkert R, White R, et al. The precursor form of IL-1 alpha is an intracrine proinflammatory activator of transcription. Proc Natl Acad Sci USA 2004;101:2434-9.
21. Canalis E. Interleukin-1 has independent effects on DNA and collagen synthesis in cultures of rat calvariae. Endocrinology 1986;118:74-81.
22. Kuroki T, Shingu M, Koshihara Y, Nobunaga M. Effect of cytokines on alkaline phosphatase and osteocalcin production, calcification and calcium release by human osteoblastic cells. Br J Rheumatol 1994;33:224-30.
23. Katz MS, Gutierrez GE, Mundy GR, Hymer TK, Caufiels MP, McKee RL. Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by downregulating parathyroid hormone receptors. J Cell Physiol 1992;153:206-13.
24. Moss DW, Eaton H, Smith JK, Whitby LG. Association of inorganic-pyrophosphatase activity with human alkaline phosphatase preparations. Biochem J 1967;102:53-7.
25. Anderson HC. Molecular biology of matrix vesicles. Clin Orthop 1995;314:266-80.
26. Goldring SR. Pathogenesis of bone erosions in rheumatoid arthritis. Curr Opin Rheumatol 2002;14:406-10.
27. Saville PD, Kharmosh O. Osteoporosis of rheumatoid arthritis: Influence of age, sex, and corticosteroids. Arthritis Rheum 1967;10:423-30.
28. Sambrook PN, Ansell BM, Foster S, Gumpel JM, Hesp R, Reeve J. Bone turnover in early rheumatoid arthritis: 2. Longitudinal bone density studies. Ann Rheum Dis 1985;44:580-4.
29. Laan RF, Buijs WC, Verbeek AL, et al. Bone mineral density in patients with recent onset rheumatoid arthritis: Influence of disease activity and functional capacity. Ann Rheum Dis 1993;52:21-6.
30. Weinreb M, Rodan GA, Thompson DD. Osteopenia in the immobilized rat hind limb is associated with increased bone resorption and decreased bone formation. Bone 1989;10:187-94.
31. Rantakokko J, Uusitalo H, Jamsa T, Tuukkanen J, Aro HT, Vuorio E. Expression profiles of mRNAs for osteoblast and osteoclast proteins as indicators of bone loss in mouse immobilization osteopenia model. J Bone Miner Res 1999;14:1934-42.
32. Compston JE, Vedi S, Mellish RW, Croucher P, O'Sullivan MM. Reduced bone formation in non-steroid treated patients with rheumatoid arthritis. Ann Rheum Dis 1989;48:483-7.
33. Compston JE, Vedi S, Croucher PI, Garrahan NJ, O'Sullivan MM. Bone turnover in non-steroid treated patients with rheumatoid arthritis. Ann Rheum Dis 1994;53:163-6.
34. Hirayama T, Danks L, Sabokbar A, Athanasou NA. Osteoclast formation and activity in the pathogenesis of osteoporosis in rheumatoid arthritis. Rheumatology Oxford 2002;41:1232-9.