Apoptotic GSH Extrusion Is Associated with Free Radical Generation

Annals of the New York Academy of Sciences

Volumn 1010, Issue , 2003, Pages 449-452

  D'Alessio, M ^a   Cerella, C ^a   De Nicola, M ^a   Bergamaschi, A ^a   Magrini, A ^a   Gualandi, G ^b   Alfonsi, A M ^b   Ghibelli, L ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF TUSCIA   (Italy)

Author keywords

Apoptosis; Glutathione; Mitochondrial transmembrane potential; Reactive oxygen species; ROS

Indexed keywords

FREE RADICAL; GLUTATHIONE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; BIOCHEMICAL COMPOSITION; CELL LEVEL; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE;

EID: 1342326764     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1299.082     Document Type: Conference Paper

References (6)

1. COPPOLA, S. & L. GHIBELLI. 2000. GSH extrusion and the mitochondrial pathway of apoptotic signalling. Biochem. Soc. Trans. 28: 56-61.
2. SUZUKI, Y.S., H.J. FORMAN & A. SEVANIAN. 1997. Oxidants as stimulators of signal transduction. Free Radical Biol. Med. 22: 269-285.
3. MARCHETTI, P. T. HIRSCH, N. ZAMZAMI, et al. 1996. Mitochondrial permeability transition triggers lymphocyte apoptosis. J. Immunol. 157(11): 4830-4836.
4. GHIBELLI, L. C. FANELLI, G. ROTILIO, et al. 1998. Rescue of cells from apoptosis by inhibition of active GSH extrusion. FASEB J. 12: 479-486.
5. GHIBELLI, L. S. COPPOLA, C. FANELLI, et al. 1999. Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis. FASEB J. 13: 2031-2036.
6. DE NICCOLA, F., C. LIUZZI, M. CERELLA, et al. 2003. Hypoxia stress stably alters apoptotic parameters on U937 cells. Ann. N.Y. Acad. Sci 1010: this volume.