Factor Va Is Inactivated by Activated Protein C in the Absence of Cleavage Sites at Arg-306, Arg-506, and Arg-679

Journal of Biological Chemistry

Volumn 279, Issue 8, 2004, Pages 6567-6575

  Van Der Neut Kolfschoten, Marijn ^a   Dirven, Richard J ^a   Vos, Hans L ^a   Tans, Guido ^b   Rosing, Jan ^b   Bertina, Rogier M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ACTIVATION; CHEMICAL RESISTANCE; MONOCLONAL ANTIBODIES; MUTAGENESIS; PHOSPHOLIPIDS; PROTEINS;

CLEAVAGE SITES; EPITOPE;

BIOCHEMISTRY;

ACTIVATED PROTEIN C; ARGININE; BLOOD CLOTTING FACTOR 5A;

ANALYTIC METHOD; ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA CLEAVAGE; GENE INACTIVATION; GENE MUTATION; GENETIC RISK; HERITABILITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ARGININE; BINDING SITES; COS CELLS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITOPES; FACTOR VA; FACTOR VIIIA; GLUTAMINE; GLYCINE; HUMANS; IMMUNOBLOTTING; KINETICS; MUTAGENESIS; MUTATION; PHOSPHOLIPIDS; PROTEIN BINDING; PROTEIN C; PROTEIN S; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TEMPERATURE; THROMBIN; TIME FACTORS;

EID: 1342304122     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308574200     Document Type: Article

References (43)

1. Owren P. A. (1947) Lancet 446-448
2. Suzuki, K., Dahlback, B., and Stenflo, J. (1982) J. Biol. Chem. 267, 6556-6564
3. Nesheim, M. E., Taswell, J. B., and Mann, K. G. (1979) J. Biol. Chem. 254, 10952-10962
4. Rosing, J., Tans, G., Govers-Riemslag, J. W., Zwaal, R. F., and Hemker, H. C. (1980) J. Biol. Chem. 255, 274-283
5. van Rijn, J. L., Govers-Riemslag, J. W., Zwaal, R. F., and Rosing, J. (1984) Biochemistry 23, 4557-4564
6. Esmon, C. T. (2000) Biochim. Biophys. Acta 1477, 349-360
7. Esmon, C. T. (2001) Thromb. Haemostasis 86, 51-56
8. Griffin, J. H., Evatt, B., Zimmerman, T. S., Kleiss, A. J., and Wideman, C. (1981) J. Clin. Investig. 68, 1370-1373
9. Comp, P. C., Nixon, R. R., Cooper, M. R., and Esmon, C. T. (1984) J. Clin. Investig. 74, 2082-2088
10. Kalafatis, M., Rand, M. D., and Mann, K. G. (1994) J. Biol. Chem. 269, 31869-31880
11. Bertina, R. M., Koeleman, B. P., Koster, T., Rosendaal, F. R., Dirven, R. J., de Ronde, H., van der Velden, P. A., and Reitsma, P. H. (1994) Nature 369, 64-67
12. Greengard, J. S., Sun, X., Xu, X., Fernandez, J. A., Griffin, J. H., and Evatt, B. (1994) Lancet 343, 1361-1362
13. Voorberg, J., Roelse, J., Koopman, R., Buller, H., Berends, F., ten Cate, J. W., Mertens, K., and van Mourik, J. A. (1994) Lancet 343, 1535-1536
14. Rosendaal, F. R., Koster, T., Vandenbroucke, J. P., and Reitsma, P. H. (1995) Blood 85, 1504-1508
15. Ridker, P. M., Hennekens, C. H., Lindpaintner, K., Stampfer, M. J., Eisenberg, P. R., and Miletich, J. P. (1995) N. Engl. J. Med. 332, 912-917
16. Rees, D. C., Cox, M., and Clegg, J. B. (1995) Lancet 346, 1133-1134
17. Williamson, D., Brown, K., Luddington, R., Baglin, C., and Baglin, T. (1998) Blood 91, 1140-1144
18. Chan, W. P., Lee, C. K., Kwong, Y. L., Lam, C. K., and Liang, R. (1998) Blood 91, 1135-1139
19. Chen, F., Zheng, Y., Xie, Q., Jian, Z., Pu, X., Xiao, B., and Liu, W. (1999) Thromb. Haemostasis 82, 105
20. Franco, R. F., Elion, J., Tavella, M. H., Santos, S. E., and Zago, M. A. (1999) Thromb. Haemostasis 81, 312-313
21. Franco, R. F., Maffei, F. H., Lourenco, D., Morelli, V., Thomazini, I. A., Piccinato, C. E., Tavella, M. H., and Zago, M. A. (1998) Br. J. Haematol. 103, 888-890
22. Heeb, M. J., Rehemtulla, A., Moussalli, M., Kojima, Y., and Kaufman, R. J. (1999) Eur. J. Biochem. 260, 64-75
23. van der Neut Kolfschoten M., Dirven, R. J., Tans, G., Rosing, J., Vos, H. L., and Bertina, R. M. (2002) Blood Coagul. Fibrinolysis 13, 207-215
24. Norstrom, E., Thorelli, E., and Dahlback, B. (2002) Blood 100, 524-530
25. Walker, F. J., Sexton, P. W., and Esmon, C. T. (1979) Biochim Biophys. Acta 571, 333-342
26. Suzuki, K., Stenflo, J., Dahlback, B., and Teodorsson, B. (1983) J. Biol. Chem. 258, 1914-1920
27. Bakker, H. M., Tans, G., Janssen-Claessen, T., Thomassen, M. C., Hemker, H. C., Griffin, J. H., and Rosing, J. (1992) Eur. J. Biochem. 208, 171-178
28. Walker, F. J. (1980) J. Biol. Chem 255, 5521-5524
29. Solymoss, S., Tucker, M. M., and Tracy, P. B. (1988) J. Biol. Chem. 263, 14884-14890
30. Nicolaes, G. A., Tans, G., Thomassen, M. C., Hemker, H. C., Pabinger, I., Varadi, K., Schwarz, H. P., and Rosing, J. (1995) J. Biol. Chem. 270, 21158-21166
31. Rosing, J., Hoekema, L., Nicolaes, G. A., Thomassen, M. C., Hemker, H. C., Varadi, K., Schwarz, H. P., and Tans, G. (1995) J. Biol. Chem. 270, 27852-27858
32. Sala, N., Owen, W. G., and Collen, D. (1984) Blood 63, 671-675
33. Guasch, J. F., Cannegieter, S., Reitsma, P. H., Van't Veer-Korthof, E. T., and Bertina, R. M. (1998) Br. J. Haematol. 101, 32-39
34. Kaufman, R. J. (1990) Methods Enzymol. 185, 487-511
35. van der Neut Kolfschoten M., Dirven, R. J., Vos, H. L., and Bertina, R. M. (2003) Thromb. Haemostasis 89, 429-437
36. Laemmli, U. K. (1970) Nature 227, 680-685
37. Hockin, M. F., Kalafatis, M., Shatos, M., and Mann, K. G. (1997) Arterioscler. Thromb. Vasc. Biol. 17, 2765-2775
38. Pellequer, J. L., Gale, A. J., Getzoff, E. D., and Griffin, J. H. (2000) Thromb. Haemostasis 84, 849-857
39. Mann, K. G., Hockin, M. F., Bean, K. J., and Kalafatis, M. (1997) J. Biol. Chem. 272, 20678-20683
40. Kane, W. H., Devore-Carter, D., and Ortel, T. L. (1990) Biochemistry 29, 6762-6768
41. Norstrom, E. A., Steen, M., Tran, S., and Dahlback, B. (2003) J. Biol. Chem. 278, 24904-24911
42. Heeb, M. J., Kojima, Y., Hackeng, T. M., and Griffin, J. H. (1996) Protein Sci. 5, 1883-1889
43. Egan, J. O., Kalafatis, M., and Mann, K. G. (1997) Protein Sci. 6, 2016-2027