A Poorly Differentiated Synovial Sarcoma (SYT/SSX1) Expresses Neuroectodermal Markers: A Xenografts and in Vitro Culture Study

Diagnostic Molecular Pathology

Volumn 13, Issue 1, 2004, Pages 52-59

  Noguera, Rosa ^a   Navarro, Samuel ^a   Lopez Guerrero, ^a   Jose, Antonio ^a   Carda, Carmen ^a   Pellín, Antonio ^a   Llombart Bosch, Antonio ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Malignant peripheral nerve sheath tumor; Primitive neuroectodermal tumor; Synovial sarcoma; SYT SSX; T(1; 16); T(1; 22); T(X; 18)

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; COMPLEMENTARY DNA; ETOPOSIDE; IFOSFAMIDE; RNA;

ANIMAL MODEL; ARTICLE; CASE REPORT; CHROMOSOME TRANSLOCATION; CYTOGENETICS; DIFFERENTIAL DIAGNOSIS; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE SHEATH TUMOR; NEUROECTODERM TUMOR; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNOVIAL SARCOMA; TUMOR CELL CULTURE; TUMOR DIAGNOSIS; XENOGRAFT;

ADULT; ANIMALS; BIOLOGICAL MARKERS; BUTTOCKS; CELL DIFFERENTIATION; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOCHEMISTRY; IN SITU HYBRIDIZATION; KARYOTYPING; MALE; MICE; MICE, NUDE; NEUROECTODERMAL TUMORS; ONCOGENE PROTEINS, FUSION; POLYMERASE CHAIN REACTION; SARCOMA, SYNOVIAL; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 1342302329     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-200403000-00009     Document Type: Article

References (45)

1. rd ed. St. Louis: CV Mosby; 1995:757.
2. Ordoñez NG, Mahfouz SM, MacKay B. Synovial sarcoma: an immunohistochemical and ultrastructural study. Hum Pathol. 1990;21:733-749.
3. Singer S, Baldini EH, Demetri GD, et al. Synovial sarcoma prognostic significance of tumor size, margin of resection, and mitotic activity for survival. J Clin Oncol. 1996;14:1201-1208.
4. Folpe AL, Schmidt RA, Chapman D, et al. Poorly differentiated synovial sarcoma. Immunohistochemical distinction from primitive neuroectodermal tumors and high-grade malignant peripheral nerve sheath tumors. Am J Surg Pathol. 1998;22:673-682.
5. Miettinen M, Cupo W. Neural cell adhesion molecule distribution in soft tissue tumors. Hum Pathol. 1993;24:62-66.
6. Fletcher CDM, Dal Cin P, de Wever I et al. Correlation between clinicopathological features and karyotype in spindle cell sarcomas. A report of 130 cases from the CHAMP Study Group. Am J Pathol. 1999;154:1841-1847.
7. Mitelman F, Johansson B, Mertens F, eds. Mitelman data-base of chromosome aberrations in cancer. http://cgap.nci.nih.gov/Chromosomes/Mitelman; 2000.
8. Noguera R, Navarro S, Cremades A, et al. Translocation (X;18) in a biphasic synovial sarcoma with morphologic features of neural differentiation. Diagn Mol Pathol. 1998;7:16-23.
9. Shipley J, Crew J, Birdsall S, et al. Interphase fluorescence in situ hybridization and reverse transcription polymerase chain reaction as a diagnostic aid for synovial sarcoma. Am J Pathol. 1996;148:559-567.
10. Mandahl N, Limon J, Mertens F, et al. Nonrandom secondary chromosome aberration in synovial sarcoma with t(X;18). Int J Oncol. 1995;7: 495-499.
11. Sandberg AA, Bridge JA. The cytogenetics of bone and soft tissue tumors. Austin, TX: Landes; 1994.
12. Clark J, Crew AJR, Gill S, et al. Identification of novel genes, SYT and SSX involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nature Genet. 1994;7:502-508.
13. Crew AJ, Clark J, Fisher C, et al. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J. 1995;14:2333-2340.
14. Fligman I, Lonardo F, Jhanwar SC, et al. Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. Am J Pathol. 1995;147:1592-1599.
15. van de Rijn M, Barr FG, Collins MH, et al. Absence of SYT-SSX fusion products in soft tissue tumors other than synovial sarcoma. Am J Clin Pathol. 1999;112:43-49.
16. dos Santos NR, de Brujin DRH, van Kessel G. Molecular mechanisms underlying human synovial sarcoma development. Genes Chrom Cancer. 2001;30:1-14.
17. Panagopoulos I, Mertens F, Isaksson M et al. Clinical impact of molecular and cytogenetic findings in synovial sarcoma. Genes Chrom Cancer. 2001;31:362-372.
18. de Leeuw B, Suijkerbuijk RF, Olde Weghuis D, et al. Distinct Xp11.2 breakpoint regions in synovial sarcoma revealed by metaphase and interphase FISH: relationship to histologic subtypes. Cancer Genet Cytogenet. 1994;73:89-94.
19. Ladanyi M, Woodruff JM, Scheithauer BW, et al. Malignant peripheral nerve sheath tumors with t(X;18). A pathologic and molecular genetic study. Mod Pathol 2000;13:1336-46. Mod Pathol. 2001;14:733-737.
20. Ladanyi M, Woodruff JM, Scheithauer BW, et al. Malignant peripheral nerve sheath tumors with t(X;18). A pathologic and molecular genetic study. Mod Pathol 2000;13:1336-46. Mod Pathol. 2001;14:733-737.
21. Mathew S, Dalton J, Riedley S, et al. Complex t(X;18)(p11.2;q11.2) with a pericentric inversion of the X chromosome in an adolescent boy with synovial sarcoma. Cancer. Genet Cytogenet. 2002;132:136-140.
22. Noguera R, Navarro S, Peydro-Olaya A, et al. Patterns of differentiation in extraosseous Ewing's sarcoma cells. Cancer 1994;73:616-624.
23. Allander SV, Illei PB, Chen Y, et al. Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation. Am J Pathol. 2002;161:1587-1595.
24. Nielsen TO, West RB, Linn SC, et al. Molecular characterisation of soft tissue tumours: a gene expression study. Lancet. 2002;359:1301-1307.
25. Smith MEF, Fisher C, Wilkinson LS, et al. Synovial sarcomas lack synovial differentiation. Histopathology. 1995;26:279-281.
26. Vang R, Biddle DA, Harrison WR, et al. Malignant peripheral nerve sheath tumor with a t(X;18). A synovial sarcoma variant? Arch Pathol Lab Med. 2000;124:864-867.
27. ISCN. An international system for human cytogenetic nomenclature, Mitelman F, ed. Basel: S. Karger; 1995.
28. Llombart-Bosch A, Pellín A, Carda C, et al. Soft tissue Ewing sarcoma-peripheral primitive neuroectodermal tumor with atypical clear cell pattern shows a new type of EWS/FEV fusion transcript. Diagn Mol Pathol. 2000;9:137-144.
29. Mastrangelo T, Modena P, Tornielli S, et al. A novel zinc finger gene is fused to EWS in small round cell tumor. Oncogene. 2000;19:3799-3804.
30. Pellín A, Boix J, Blesa JR, et al. EWS/FLI-1 rearrangement in small round cell sarcomas of bone and soft tissue detected by reverse transcriptase polymerase chain reaction amplification. Eur J Cancer. 1994;30:827-831.
31. Noguera R, Triche TJ, Navarro S, et al. Dynamic model of differentiation in Ewing's sarcoma cells. Comparative analysis of morphologic, immunocytochemical, and oncogene expression parameters. Lab Invest. 1992; 66:143-151.
32. Pelmus, M, Guillou L, Hostein I, et al. Monophasic Fibrous and poorly differentiated synovial sarcoma: immunohistochemical reassessment of 60 t(X;18)(SYT-SSX)-positive cases. Am J Surg Pathol. 2002;26:1434-1440.
33. DeiTos AP, Wadden C, Calonje E, et al. Immunohistohemical demonstration of p30/32MIC2 (CD99) in synovial sarcoma. A potential cause of diagnostic confusion. Appl Immumohistochem. 1995;3:168-173.
34. Hirose T, Hasegawa T, Kudo E, et al. Malignant peripheral nerve sheath tumors: an immunohistochemical study in relation to ultrastructural features. Hum Pathol. 1992;23:865-870.
35. Ladanyi M, Heinemann FS, Huvos AG, et al. Neural differentiation in small round cell tumors of bone and soft tissue with the translocation t(11;22)(q24;q12); on immunohistochemical study of 11 cases. Hum Pathol. 1990;231:1245-1251.
36. Llombart-Bosch A, Navarro S. Immunohistochemical detection of EWS and FLI-1 proteins in Ewing sarcoma and primitive neuroectodermal tumors: comparative analysis with CD99 (MIC-2) expression. Appl Immunohist & Mol Morphology. 2001;9:255-260.
37. Coindre JM, Hostein I, Benhattar J, et al. Malignant peripheral nerve sheath tumors are t(X;18)-negative sarcomas. Molecular analysis of 25 cases occurring in neurofibromatosis type 1 patients, using two different RT-PCR-based methods of detection. Mod Pathol. 2002;15:589-592.
38. Tamborini E, Agus V, Perrone F, et al. Lack of SYT-SSX fusion transcripts in malignant peripheral nerve sheath tumors on RT-PCR analysis of 34 archival cases. Lab Invest. 2002;82:609-618.
39. Skytting BT, Szymanska J, Aalto Y, et al. Clinical importance of genomic imbalances in synovial sarcoma evaluated by comparative genomic hybridization. Cancer Genet Cytogenet. 1999a;115:39-46.
40. Szymanska J, Serra M, Skytting B, et al. Genetic inbalances in 67 synovial sarcomas evaluated by comparative genomic hybridization. Genes Chrom Cancer. 1998;23:213-219.
41. Hattinger CM, Rumpler S, Strehl S, et al. Prognostic impact of deletions at 1p36 and numerical aberrations in Ewing tumors. Genes Chrom Cancer. 1999;24:243-254.
42. de Brujin DRH, Baats E, Zechncr U, et al. Isolation and characterization of the mouse homolog of SYT, a gene implicated in the development of human synovial sarcoma. Oncogene. 1996;13:643-648.
43. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in humans. Nature. 1998;396:643-649.
44. Nogueira E, Navarro S, Pellin A, et al. Activation of TRK genes in Ewing's sarcoma. Trk A receptor expression linked to neural differentiation. Diagn Mol Pathol 1997;6:10-16.
45. Sandberg AA, Bridge JA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma. Cancer Genet Cytogenet. 2002;133:1-23.