Activation of TRK genes in Ewing's sarcoma: Trk A receptor expression linked to neural differentiation

Diagnostic Molecular Pathology

Volumn 6, Issue 1, 1997, Pages 10-16

  Nogueira, Enrique ^a,b   Navarro, Samuel ^a   Pellín, Antonio ^a   Llombart Bosch, Antonio ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

Author keywords

Ewing's sarcoma; Immunohistochemistry; polymerase chain reaction; Reverse transcription; Trk A, B, and C receptors

Indexed keywords

ARTICLE; BREAST CANCER; CELL DIFFERENTIATION; COLON CANCER; EWING SARCOMA; GENE ACTIVATION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; KIDNEY CANCER; LYMPHOMA; NERVE CELL; NEUROBLASTOMA; OSTEOSARCOMA; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, NEOPLASTIC; MEMBRANE PROTEINS; MICE; NEUROECTODERMAL TUMORS, PRIMITIVE; NEURONS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; RECEPTOR, TRKA; RECEPTOR, TRKC; RECEPTORS, NERVE GROWTH FACTOR; SARCOMA, EWING'S;

EID: 0031057476     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-199702000-00003     Document Type: Article

References (24)

1. Ambros IM, Ambros PF, Strehl S, Kovar H, Gadner H, Salzer-Kuntschik M. MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Cancer 1991;67:1886-93.
2. Barbacid M. The Trk family of neurotrophic factors. J Neurobiol 1994;25:1386-403.
3. Dehner LP. Primitive neuroectodermal tumor and Ewing's sarcoma. Am J Surg Pathol 1993;17:1-13.
4. Donovan MJ, Hempstead BL, Horvath C, Chao MV, Schofield D. Immunohistochemical localization of Trk receptor protein in pediatric small round blue cell tumors. Am J Pathol 1993;143:1560-7.
5. MG62), neuron-specific enolase, and vimentin in the immunohistochemical analysis of Ewing's sarcoma of bone. Am J Surg Pathol 1992;16:746-55.
6. Fletcher JA. Cytogenetic observations in malignant soft tissue tumors. Adv Pathol Lab Med 1991;4:235-46.
7. Hoehner JC, Olsen L, Sandstedt B, Kaplan DR, Pahlman S. Association of neurotrophin receptor expression and differentiation in human neuroblastoma. Am J Pathol 1995;147: 102-13.
8. Klein R, Parada LF, Coulier F, Barbacid M. TrkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J 1989;8:3701-9.
9. Klein R, Silos-Santiago I, Smeyne RJ, et al. Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements. Nature 1994; 368:249-51.
10. Klein R, Smeyne RJ, Wurst W, et al. Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell 1993;75:113-22.
11. Lamballe F, Klein R, Barbacid M. TrkC, a new member of the trk family of tyrosine protein kinases is a receptor for neurotrophin-3. Cell 1991;66:1-20.
12. Lamballe F, Tapley P, Barbacid M. TrkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities. EMBO J 1993;12:3083-94.
13. Lamballe F, Smeyne RJ, Barbacid M. Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system. J Neurosci 1994;14:14-28.
14. Llombart-Bosch A, Carda C, Peydró-Olaya A, et al. Soft tissue Ewing's sarcoma: characterization in established cultures and xenografts with evidence of a neuroectodermic phenotype. Cancer 1990;66:2589-601.
15. Llombart-Bosch A, Lacombe MJ, Contesso G, Peydró-Olaya A. Small round blue cell sarcoma of bone mimicking atypical Ewing's sarcoma with neuroectodermal features: an analysis of five cases with immunohistochemical and electron microscopic support. Cancer 1987;60:1570-82.
16. Llombart-Bosch A, Terrier-Lacombe MJ, Peydró-Olaya A, Contesso G. Peripheral neuroectodermal sarcoma of soft tissue (peripheral neuroepithelioma): a pathologic study often cases with differential diagnosis regarding other small round cell sarcomas. Hum Pathol 1989;20:273-80.
17. trkB in primary hippocampal cell culture. J Neurosci 1993;13:4281-92.
18. Martín-Zanca D, Oscam R, Mitra G, Copeland T, Barbacid M. Molecular and biochemical characterization of the human trk proto-oncogene. Mol Cell Biol 1989;9:24-33.
19. Nakagawara A, Arima-Nakagawara M, Scavarda NJ, Azar C, Cantor A, Brodeur GM. Association between high levels of expression of the trk gene and favorable outcome in human neuroblastoma. N Engl J Med 1993;328:847-54.
20. Navarro S, Cavazzana AO, Llombart-Bosch A, Triche TJ. Comparison of Ewing's sarcoma of bone and peripheral neuroepithelioma: an immunocytochemical and ultrastructural analysis of two primitive neuroectodermal neoplasms. Arch Pathol Lab Med 1994;118:608-15.
21. Rettig WJ, Garin-Chesa P, Huvos AG. Ewing's sarcoma: new approaches to histogenesis and molecular plasticity. Lab Invest 1992;66:133-7.
22. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press, 1989.
23. Smeyne RJ, Klein R, Schnapp A, et al. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/ NGF receptor gene. Nature 1994;368:246-9.
24. Terrier PP, Henry-Amar M, Triche TJ, et al. Is neuroectodermal differentiation of Ewing's sarcoma of bone associated with an unfavourable prognosis? Eur J Cancer 1995; 31:307-14.