Multilocus effects of the renin-angiotensin-aldosterone system genes on blood pressure response to a thiazide diuretic

Pharmacogenomics Journal

Volumn 4, Issue 1, 2004, Pages 17-23

  Frazier, L ^a   Turner, S T ^b   Schwartz, G L ^b   Chapman, A B ^c   Boerwinkle, Eric ^d,e  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON   (United States)

^b MAYO CLINIC   (United States)

^c EMORY UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

African americans; Diuretics; Gender; Genetics; Hypertension; Polymorphisms; RAA system

Indexed keywords

ADENINE; ALDOSTERONE; ALDOSTERONE SYNTHASE; ANGIOTENSIN; ANGIOTENSIN RECEPTOR; ANGIOTENSINOGEN; ANTIHYPERTENSIVE AGENT; CYTOSINE; DIPEPTIDYL CARBOXYPEPTIDASE; GUANINE; RENIN; THIAZIDE DIURETIC AGENT;

ADULT; AFRICAN AMERICAN; ARTICLE; BLOOD PRESSURE REGULATION; CAUCASIAN; CONTROLLED STUDY; DRUG RESPONSE; FEMALE; GENDER; GENE LOCUS; GENE MUTATION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HISPANIC; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RACE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STATISTICAL ANALYSIS;

ADULT; AFRICAN AMERICANS; ANGIOTENSINOGEN; BENZOTHIADIAZINES; BLOOD PRESSURE; DIURETICS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC MARKERS; HISPANIC AMERICANS; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTOR, ANGIOTENSIN, TYPE 1; RENIN-ANGIOTENSIN SYSTEM; SODIUM CHLORIDE SYMPORTER INHIBITORS; VARIATION (GENETICS);

PIERINAE;

EID: 1342289661     PISSN: 1470269X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.tpj.6500215     Document Type: Article

References (26)

1. Beevers GD, MacGregor GA Hypertension in Practice, , 3rd edn. Blackwell Science, Inc: Malden, MA 1999.
2. Elliott W Hypertension Therapy Annual. Blackwell Science Inc: Malden, MA 2000.
3. Kaplan MN Kaplna's Clinical Hypertension,, 8th edn. Lippincott Williams and Wilkins: New York 2002.
4. Materson BJ, Reda DJ, Cushman WC, Massie BM, Freis ED, Kochar MS et al. Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on antihypertensive Agents. N Engl J Med 1993; 328: 914-921.
5. Chapman AB, Schwartz GL, Boerwinkle E, Turner S. Predictors of antihypertensive response to a standard dose of hydrochlorothiazide for essential hypertension. Kidney Int 2002; 61: 1047-1055.
6. Pachori AS, Huentelman MJ, Francis SC, Gelband CH, Katovich MJ, Raizada MK. The future of hypertension therapy: sense, antisense or nonsense? Hypertension 2001; 37: 357-364.
7. Soldner A, Spahn-Langguth H, Mutschler E. The renin-angiotensin-aldosterone system: focus on its distinct role in arterial hypertension and its various inhibitors as a therapeutic strategy to effectively lower blood pressure. Pharmazie 1996; 51: 783-799.
8. Sidawy AN, Sumpio BE, DePalma RG The Basic Science of Vascular Biology. Futura Publishing Company Inc: Armonk, NY 1997.
9. Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A et al. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet 1999; 22: 239-247.
10. Fox ST Human Physiology. Wm.C.Brown Publishers: Dubuque, IA 1984.
11. Turner ST, Boerwinkle E, Sing CF. Context-dependent associations of the ACE I/D polymorphism with blood pressure. Hypertension 1999; 34(Part 2): 773-778.
12. Matsubara M, Kikuya M, Ohkubo T, Metoki H, Omori F, Fujiwara T et al. Aldosterone synthase gene (CYP11B2) C-334T polymorphism, ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population: the Ohasama Study. J Hypertens 2001; 19: 2179-2184.
13. Schwartz GL, Turner ST, Chapman AB, Boerwinkle E. Interacting effects of gender and genotype on blood pressure response to hydrochlorothiazide. Kidney Int 62: 1718-1723.
14. Duncan JA, Scholey JW, Miller JA. Angiotensin II type I receptor gene polymorphisms in humans: physiology and pathophysiology of the genotypes. Curr Opin Nephrol Hypertens 2001; 1: 111-116.
15. Inoue I, Nakajima T, Williams CS, Quackenbush J, Puryear R, Powers M et al. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest 1997; 99: 1786-1797.
16. Hunt SC, Geleijnse JM, Wu LL, Witteman JC, Williams RR, Grobbee DE. Enhanced blood pressure response to mild sodium reduction in subjects with the 235T variant of the angiotensinogen gene. Am J Hypertens 1999; 12: 460-466.
17. Miller JA, Thai K, Scholey JW. Angiotensin II type 1 receptor gene polymorphism predicts response to losartan and angiotensin II. Kidney Int 56: 2173-2180.
18. Jeunemaitre X, Gimenez-Roqueplo AP, Celerier J, Corvol P. Angiotensinogen variants and human hypertension. Curr Hypertens Rep 1999; 1: 31-41.
19. Schwartz GL, Turner ST, Chapman AB, Boerwinkle E. Interacting effects of gender and genotype on blood pressure response to hydrochlorothiazide. Kidney Int 2002; 62: 1718-1723.
20. Hingorani AD, Jia H, Stevens PA, Hopper R, Dickerson JE, Brown MJ. Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition. J Hypertens 1995; 13: 1602-1609.
21. Miller JA, Thai K, Scholey JW. Angiotensin II type 1 receptor gene polymorphism predicts response to losartan and angiotensin II. Kidney Int 1999; 56: 2173-2180.
22. Williams SM, Addy JH, Phillips III JA, Dai M, Kpodonu J, Afful J et al. Combinations of variations in multiple genes are associated with hypertension. Hypertension 2000; 36: 2-6.
23. Schwartz GL, Turner ST, Chapman AB, Boerwinkle E. Interacting effects of gender and genotype on blood pressure response to hydrochlorothiazide: interacting effects of gender and genotype on blood pressure response to hydrochlorothiazide. Kidney Int 62: 1718-1723.
24. Sethi AA, Nordestgaard BG, Agerholm-Larsen B, Frandsen E, Jensen G, Tybjaerg-Hansen A. Angiotensinogen polymorphisms and elevated blood pressure in the general population. Hypertension 2001; 37: 875-881.
25. Sethi AA, Nordestgaard BG, Agerholm-Larsen B, Frandsen E, Jensen G, Tybjaerg-Hansen A. Angiotensinogen polymorphisms and elevated blood pressure in the general population the Copenhagen City Heart Study. Hypertension 2001; 37: 875-881.
26. Jeunemaitre X, Inoue I, Williams C, Charru A, Tichet I, Powers M et al. Haplotypes of angiotensinogen in essential hypertension. Am J Hum Genet 1997; 60: 1448-1460.