Increased invasive capacity of connexin43-overexpressing malignant glioma cells

Journal of Neurosurgery

Volumn 99, Issue 6, 2003, Pages 1039-1046

  Zhang, Wei ^b   Nwagwu, Chiedozie ^b   Le, Duc Minh ^b   Yong, V Wee ^b   Song, Hua ^b   Couldwell, William T ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Connexin; Glioma; Matrigel; Matrix metalloproteinase

Indexed keywords

CONNEXIN 43; MATRIGEL; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; CONNEXIN 32; GAP JUNCTION PROTEIN; GELATINASE A; GELATINASE B;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; CULTURE MEDIUM; GLIOBLASTOMA; GLIOMA CELL; NONHUMAN; PRIORITY JOURNAL; RAT; ZYMOGRAPHY; ANIMAL; CANCER INVASION; CELL COMMUNICATION; CELL CULTURE; CELL JUNCTION; CELL MOTION; COCULTURE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; GLIOMA; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ASTROCYTES; CELL COMMUNICATION; CELL MOVEMENT; COCULTURE TECHNIQUES; CONNEXIN 43; CONNEXINS; GAP JUNCTIONS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; RATS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 1342289507     PISSN: 00223085     EISSN: 00223085     Source Type: Journal    
DOI: 10.3171/jns.2003.99.6.1039     Document Type: Article

References (34)

1. Amberger VR, Hensel T, Ogata N, et al: Spreading and migration of human glioma and rat C6 cells on central nervous system myelin in vitro is correlated with tumor malignancy and involves a metalloproteolytic activity. Cancer Res 58:149-158, 1998
2. Bernstein JJ, Goldberg WJ, Laws ER Jr, et al: C6 glioma cell invasion and migration of rat brain after neural homografting: ultrastructure. Neurosurgery 26:622-628, 1990
3. Bernstein LR, Liotta LA: Molecular mediators of interactions with extracellular matrix components in metastasis and angiogenesis. Curr Opin Oncol 6:106-113, 1994
4. Burger PC, Vollmer RT: Histologic factors of prognostic significance in the glioblastoma multiforme. Cancer 46:1179-1186, 1980
5. Chicoine MR, Silbergeld DL: Assessment of brain tumor cell motility in vivo and in vitro. J Neurosurg 82:615-622, 1995
6. Chintala SK, Fueyo J, Gomez-Manzano C, et al: Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro. Oncogene 15:2049-2057, 1997
7. Chintala SK, Sawaya R, Aggarwal BB, et al: Induction of matrix metalloproteinase-9 requires a polymerized actin cytoskeleton in human malignant glioma cells. J Biol Chem 273:13545-13551, 1998
8. Cotrina ML, Lin JH, Nedergaard M: Cytoskeletal assembly and ATP release regulate astrocytic calcium signaling. J Neurosci 18: 8794-8804, 1998
9. Dermietzel R, Spray DC: Gap junctions in the brain: where, what type, how many and why? Trends Neurosci 16:186-192, 1993
10. Frosch BA, Sloane BF: The role of proteolytic enzymes in brain tumor infiltration, in Mikkelsen T, Bjerkvig R, Laerum OD, et al (eds): Brain Tumor Invasion: Biological, Clinical and Therapeutic Considerations. New York: Wiley-Liss, Inc: 1998, pp 275-300
11. Giese A, Westphal M: Glioma invasion in the central nervous system. Neurosurgery 39:235-252, 1996
12. Graeber SH, Hulser DF: Connexin transfection induces invasive properties in HeLa cells. Exp Cell Res 243:142-149, 1998
13. Grobben B, De Deyn PP, Siegers H: Rat C6 glioma as experimental model system for the study of glioblastoma growth and invasion. Cell Tissue Res 310:257-270, 2002
14. Horwitz AR, Parsons JT: Cell migration-movin' on. Science 286:1102-1103, 1999
15. Kaya M, Yoshida K, Higashino F, et al: A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells. Oncogene 12:221-227, 1996
16. Knott JC, Mahesparan R, Garcia-Cabrera I, et al: Stimulation of extracellular matrix components in the normal brain by invading glioma cells. Int J Cancer 75:864-872, 1998
17. Lauffenburger DA, Horwitz AF: Cell migration: a physically integrated molecular process. Cell 84:359-369, 1996
18. Lin JHC, Takano T, Cotrina ML, et al: Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells. J Neurosci 22:4302-4311, 2002
19. Liotta LA, Stetler-Stevenson WG: Metalloproteinases and cancer invasion. Semin Cancer Biol 1:99-106, 1990
20. Nagano N, Sasaki H, Aoyagi M, et al: Invasion of experimental rat brain tumor: early morphological changes following microinjection of C6 glioma cells. Acta Neuropathol 86:117-125, 1993
21. Naus CC, Zhu D, Todd SD, et al: Characteristics of C6 glioma cells overexpressing a gap junction protein. Cell Mol Neurobiol 12:163-175, 1992
22. Naus CCG, Bechberger JF, Bond SL: Effect of gap junctional communication on glioma cell function, in Spray DC, Dermietzel R (eds): Neuroscience Intelligence Unit: Gap Junctions in the Nervous System. Austin, TX: RG Landes, 1996, pp 193-202
23. Paulus W, Baur I, Schuppan D, et al: Characterization of integrin receptors in normal and neoplastic human brain. Am J Pathol 143:154-163, 1993
24. Pedersen PH, Marienhagen K, Mork S, et al: Migratory pattern of fetal rat brain cells and human glioma cells in the adult rat brain. Cancer Res 53:5158-5165, 1993
25. Rao JS, Steck PA, Mohanam S, et al: Elevated levels of M(r) 92,000 type IV collasenase in human brain tumors. Cancer Res 53 (Suppl 10):2208-2211, 1993
26. Salazar OM, Rubin P: The spread of glioblastoma multiforme as a determining factor in the radiation treated volume. Int J Radiat Oncol Biol Phys 1:627-637, 1976
27. Sawaya RE, Yamamoto M, Gokaslan ZL, et al: Expression and localization of 72 kDa type IV collagenase (MMP-2) in human malignant gliomas in vivo. Clin Exp Metastasis 14:35-42, 1996
28. Shinoura N, Chen L, Wani MA, et al: Protein and messenger RNA expression of connexin43 in astrocytomas: implications in brain tumor gene therapy. J Neurosurg 84:839-846, 1996
29. Uhm JH, Dooley NP, Villemure JG, et al: Glioma invasion in vitro: regulation by matrix metalloprotease-2 and protein kinase C. Clin Exp Metastasis 14:421-433, 1996
30. Yamane Y, Shiga H, Asou H, et al: Dynamics of astrocyte adhesion as analyzed by a combination of atomic force microscopy and immuno-cytochemistry: the involvement of actin filaments and connexin 43 in the early stage of adhesion. Arch Histol Cytol 62:355-361, 1999
31. Yong VW, Krekoski CA, Forsyth PA, et al: Matrix metalloproteinases and diseases of the CNS. Trends Neurosci 21:75-80, 1998
32. Zhang W, Couldwell WT, Simard MF, et al: Direct gap junction communication between malignant glioma cells and astrocytes. Cancer Res 59:1994-2003, 1999
33. Zhang W, Law RE, Hinton DR, et al: Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor. Cancer Lett 120:31-38, 1997
34. Zhu D, Kidder GM, Caveney S, et al: Growth retardation in glioma cells cocultured with cells overexpressing a gap junction protein. Proc Natl Acad Sci USA 89:10218-10221, 1992