Criteria for the Interpretation of Cocaine Levels in Human Biological Samples and Their Relation to the Cause of Death

American Journal of Forensic Medicine and Pathology

Volumn 25, Issue 1, 2004, Pages 1-10

  Stephens, Boyd G ^a   Jentzen, Jeffrey M ^b   Karch, Steven ^a   Mash, Deborah C ^c   Wetli, Charles V ^d  

^a Office of the Chief Medical Examiner   (United States)

^b Milwaukee County Medical Examiner's Office   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d Suffolk County Medical Examiner's Office   (United States)

Author keywords

Cause of death; Cocaine; Forensic toxicology; Manner of death; Scene investigation

Indexed keywords

COCAINE; DRUG RESIDUE;

ADULT; ANAMNESIS; AUTOPSY; BLOOD ANALYSIS; BLOOD SAMPLING; CASE REPORT; CAUSE OF DEATH; COCAINE DEPENDENCE; CORE TEMPERATURE; DOCUMENTATION; DRUG BILE LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DETERMINATION; DRUG HAIR LEVEL; DRUG METABOLISM; DRUG URINE LEVEL; FEMALE; FORENSIC PATHOLOGY; HUMAN; MALE; MESOLIMBIC DOPAMINERGIC SYSTEM; NEUROCHEMISTRY; POLICE; REVIEW; VITREOUS BODY;

BILE; BRAIN CHEMISTRY; CEREBROSPINAL FLUID; COCAINE; DOPAMINE UPTAKE INHIBITORS; FORENSIC MEDICINE; HAIR; HUMANS; POISONING; VITREOUS BODY;

EID: 1342268050     PISSN: 01957910     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.paf.0000118960.58334.a9     Document Type: Review

References (14)

1. Karch SB. A Brief History of Cocaine. Boca Raton, FL: CRC Press; 1998.
2. U. S. Department of Justice, Drug Enforcement Administration, Drug Statistics, 1999. Available at: http://www.usdoj.gov/dea/stats/drugstats.htm. Accessed on Janurary 24, 2003.
3. Mittleman RE, Wetli CV. The Pathology of Cocaine Abuse. Advances in Pathology and Laboratory Medicine. Saint Louis, MO: Mosby-Year Book Inc.; 1991.
4. Staley JK, Hearn WL, Ruttenber AJ, et al. High affinity cocaine recognition sites on the dopamine transporter are elevated in fatal cocaine overdose victims. J Pharmacol Exp Ther. 1994;271:1678-1685.
5. Staley JK, Rothman RB, Rice KC, et al. Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims. J Neurosci. 1997;17:8225-8233.
6. Wetli CV, Mash D, Karch SB. Cocaine-associated agitated delirium and the neuroleptic malignant syndrome. J Emerg Med. 1996;14:425-428.
7. Karch SB. Introduction to the Forensic Pathology of Cocaine. Am J Forensic Med Pathol. 1991;12:126-131.
8. Karch SB. Interpretation of Blood Cocaine and Metabolite Concentrations. J Emerg Med. 2000;18:635-636.
9. Hearn WL, Flynn DD, Himes GW, et al. Cocaethylene: A unique cocaine metabolite displays high affinity for the dopamine transporter. J Neurochem. 1991;56:698-701.
10. Blaho K, Logan B, Winbery S, et al. Blood cocaine and metabolite concentrations, clinical findings, and outcome of patients presenting to an ED. J Emerg Med. 2000;18:593-598.
11. Bauman JL, Di Domenico RJ. Cocaine-induced channelopathies: emerging evidence on the multiple mechanisms of sudden death. J Cardiovasc Pharmacol Ther. 2002;7:195-202.
12. Mash DC, Pablo J, Ouyang Q, et al. Dopamine transport function is elevated in cocaine users. J Neurochem. 2002;81:292-300.
13. Williams RH, Erickson T, Broussard LA. Evaluating sympathomimetic intoxication in an emergency setting. Lab Med. 2000;31:497-507.
14. Cause of death tutorials. These two sources offer compliance suggestions for writing cause of death statements and determining manner of death in accordance with CDC guidelines. Available at: http://www.the-name.org/library_index.htm, and http://www.cap.org/html/publications/ deathpubs.html. Accessed on January 24, 2003.