Effects of aerobic exercise training on the protein kinase B (PKB)/mammalian target of rapamycin (mTOR) signaling pathway in aged skeletal muscle

Experimental Gerontology

Volumn 39, Issue 3, 2004, Pages 379-385

  Reynolds IV, Thomas H ^a,c   Reid, Pamela ^a   Larkin, Lisa M ^a   Dengel, Donald R ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c ITHACA COLLEGE   (United States)

Author keywords

Contractile activity; mRNA translation; Protein synthesis; Voluntary wheel running

Indexed keywords

PROTEIN KINASE B;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME PHOSPHORYLATION; EXERCISE; GASTROCNEMIUS MUSCLE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RUNNING; SIGNAL TRANSDUCTION; SITTING; SKELETAL MUSCLE; SOLEUS MUSCLE;

MAMMALIA;

EID: 1342265402     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2003.12.005     Document Type: Article

References (33)

1. Alessi D.R., Andjelkovic M., Caudwell F.B., Cron P., Morrice N., Cohen P., Hemmings B.A. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15:(23):1996;6541-6551.
2. S6k correlates with increased skeletal muscle mass following resistance training. Am. J. Physiol. 45:1999;C120-C127.
3. Balagopal P., Rooyackers O.E., Adey D.B., Ades P.A., Nair K.S. Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans. Am. J. Physiol. 273:(36):1997;E790-E800.
4. Balagopal P., Schimke J.C., Ades P., Adey D., Nair K.S. Age effect on transcript levels and synthesis rate of muscle MHC and response to resistance exercise. Am. J. Physiol. Endocrinol. Metab. 280:(2):2001;E203-E208.
5. Bodine S.C., Stitt T.N., Gonzalez M., Kline W.O., Stover G.L., Bauerlein R., Zlotchenko E., Scrimgeour A., Lawrence J.C., Glass D.J., Yancopoulos G.D. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat. Cell Biol. 3:2001;1014-1019.
6. Brooks S.V., Faulkner J.A. Contractile properties of skeletal muscles from young, adult and aged mice. J. Physiol. 404:1988;71-82.
7. Brooks S.V., Opiteck J.A., Faulkner J.A. Conditioning of skeletal muscles in adult and old mice for protection from contraction-induced injury. J. Gerontol. 56:(4):2001;B163-B171.
8. Brown M., Ross T.P., Holloszy J.O. Effects of aging and exercise on soleus and extensor digitorum longus muscles of female rates. Mech. Ageing Dev. 63:1992;69-77.
9. Brunn G.J., Fadden P., Haystead T.A.J., Lawrence J.C. The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. J. Biol. Chem. 272:1997;32547-32550.
10. Chibalin A.V., Yu M., Ryder J.W., Song X.M., Galuska D., Krook A., Wallberg-Henriksson H., Zierath J.R. Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor substrates 1 and 2. Proc. Natl Acad. Sci. USA. 97:(1):2000;38-43.
11. Fiatarone M.A., Marks E.C., Ryan N.D., Meredith C.N., Lipsitz L.A., Evans W.J. High-intensity strength training in nonagenarians. Effects on skeletal muscle. JAMA. 263:(22):1990;3029-3034.
12. Hasten D.L., Pak-Loduca J., Obert K.A., Yarasheski K.E. Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78-84 and 23-32 yr olds. Am. J. Physiol. Endocrinol. Metab. 278:(4):2000;E620- E626.
13. Holloszy J.O., Chen M., Cartee G.D., Young C. Skeletal muscle atrophy in old rats: differential changes in three fiber types. Mech. Ageing Dev. 60:1991;199-213.
14. Jessen N., Pold R., Buhl E.S., Jensen L.S., Schmitz O., Lund S. Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles. J. Appl. Physiol. 94:(4):2003;1373-1379.
15. 2 max and running performance in rats. J. Appl. Physiol. 68:1990;400-403.
16. Lexall J., Taylor C.C., Sjostrom M. What is the cause of the ageing atrophy? Total number, size, and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J. Neurol. Sci. 84:1988;275-294.
17. Luciano E., Carneiro E.M., Carvalho C.R., Carvalheira J.B., Peres S.B., Reis M.A., Saad M.J., Boschero A.C., Velloso L.A. Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. Eur. J. Endocrinol. 147:(1):2002;149-157.
18. Munoz K.A., Aannestad A., Tischler M.E., Henriksen E.J. Skeletal muscle protein content and synthesis after voluntary running and subsequent unweighting. Metabolism. 43:(8):1994;994-999.
19. Nave B.T., Ouwens D.M., Withers D.J., Alessi D.R., Shepherd P.R. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem. J. 344:1999;427-431.
20. Reynolds T.H., Bodine S.C., Lawrence J.C. Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. J. Biol. Chem. 277:(20):2002;17657-17662.
21. Rodnick K.J., Reaven G.M., Haskell W.L., Sims C.R., Mondon C.E. Variations in running activity and enzymatic adaptations in voluntary running rats. J. Appl. Physiol. 66:(3):1989;1250-1257.
22. Rooyackers O.E., Adey D.B., Ades P.A., Nair K.S. Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proc. Natl Acad. Sci. USA. 93:(26):1996;15364-15369.
23. Sabers C.J., Martin M.M., Brunn G.J., Williams J.M., Dumont F.J., Wiederrecht G., Abraham R.T. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J. Biol. Chem. 270:1995;815-822.
24. Scott P.H., Brunn G.J., Kohn A.D., Roth R.R., Lawrence J.C. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc. Natl Acad. Sci. USA. 95:1998;7772-7777.
25. Sekulic A., Hudson C.C., Homme J.L., Yin P., Otterness D.M., Karnitz L.M., Abraham R.T. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 60:(13):2000;3504-3513.
26. Shah O.J., Anthony J.C., Kimball S.R., Jefferson L.S. 4E- BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle. Am. J. Physiol. 279:2000;E715-E729.
27. Srere P.A. Citrate synthase. Meth. Enzymol. 13:1969;3-5.
28. Tanner C.J., Koves T.R., Cortright R.L., Pories W.J., Kim Y.B., Kahn B.B., Dohm G.L., Houmard J.A. Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men. Am. J. Physiol. Endocrinol. Metab. 282:(1):2002;E147-E153.
29. Tischler M.E. Estimation of protein synthesis and proteolysis in vitro. Nissen S. Modern methods in protein nutrition and Metabolism. 1992;Academic Press, New York. pp. 225-250.
30. Volpi E., Sheffield-Moore M., Rasmussen B.B., Wolfe R.R. Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA. 286:(10):2001;1206-1212.
31. Willis P.E., Chadan S., Baracos V., Parkhouse W.S. Restoration of insulin-like growth factor I action in skeletal muscle of old mice. Am. J. Physiol. 275:1998;E525-E530.
32. Yarasheski K.E., Zachwieja J.J., Bier D.M. Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. Am. J. Physiol. 265:(2):1993;E210-E214.
33. Yarasheski K.E., Pak-Loduca J., Hasten D.L., Obert K.A., Brown M.B., Sinacore D.R. Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men >76 yr old. Am. J. Physiol. 277:(1):1999;E118-E125.