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Volumn 13, Issue 1, 2005, Pages 2-8

New paradigm for the roles of fungi and eosinophils in chronic rhinosinusitis

Author keywords

Allergic fungal sinusitis; Chronic rhinosinusitis; Chronic sinusitis; Eosinophils; Fungi; Inflammation

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; CORTICOSTEROID; IMMUNOGLOBULIN E; INTERCELLULAR ADHESION MOLECULE 1; ITRACONAZOLE; MAJOR BASIC PROTEIN; MUCIN;

EID: 13244298250     PISSN: 10689508     EISSN: None     Source Type: Journal    
DOI: 10.1097/00020840-200502000-00003     Document Type: Review
Times cited : (67)

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    • 11344264163 scopus 로고    scopus 로고
    • Treatment of chronic rhinosinusitis with intranasal amphotericin B: A randomized, placebo-controlled, double-blinded pilot trial
    • in press
    • Ponikau JU, Sherris DA, Weaver A, et al. Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blinded pilot trial. J Allergy Clin Immunol 2005; in press. This is the first double-blind, placebo-controlled trial of consecutive and unselected patients with chronic rhinosinusitis using a bulb syringe as a delivery vehicle. This study demonstrates a reduced inflammatory mucosal thickening on CT scan and nasal endoscopy and decreased levels of intranasal cytokines and markers for eosinophilic inflammation in chronic rhinosinusitis patients compared with placebo after 6 months. These results suggest a beneficial effect of topical antifungal treatment of patients with chronic rhinosinusitis when appropriate delivery methods of the medication and a sufficient duration of the treatment are considered.
    • (2005) J Allergy Clin Immunol
    • Ponikau, J.U.1    Sherris, D.A.2    Weaver, A.3


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