Genotype phenotype correlations in Israeli colorectal cancer patients

International Journal of Cancer

Volumn 114, Issue 1, 2005, Pages 58-73

  Starinsky, Sigal ^a   Figer, Arie ^c   Ben Asher, Edna ^d   Geva, Ravit ^c   Flex, Dov ^e,f   Fidder, Herma H ^b   Zidan, Jamal ^g,h   Lancet, Doron ^d   Friedman, Eitan ^a  

^a GERTNER INSTITUTE FOR EPIDEMIOLOGY AND HEALTH POLICY RESEARCH   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^d WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^e RABIN MEDICAL CENTER   (Israel)

^f TEL AVIV UNIVERSITY   (Israel)

^g Rebecca Sieff Government Hospital   (Israel)

^h TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Colorectal cancer; Genotype phenotype correlation; Hardy Weinberg equilibrium; SNP; Tumor phenotype

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); APC PROTEIN; APOLIPOPROTEIN E; BETA CATENIN; DNA; GENE PRODUCT; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN DCC; PROTEIN MSH2; PROTEIN P15; PROTEIN P16; PROTEIN P53; PROTEIN RB1; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

ADULT; AGED; APOE GENE; ARTICLE; BETA CATENIN GENE; CANCER GRADING; CANCER PATIENT; CELL ONCOGENE; COHORT ANALYSIS; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; ERCC2 GENE; ETHNIC GROUP; FAMILY HISTORY; FEMALE; FOLLOW UP; GENETIC POLYMORPHISM; GENOTYPE PHENOTYPE CORRELATION; HEREDITY; HMSH2 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; ISRAEL; JEW; MAJOR CLINICAL STUDY; MALE; MTHFR GENE; ONCOGENE; ONCOGENE K RAS; P15 GENE; PATHOGENESIS; PRIORITY JOURNAL; PTEN GENE; RB1 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR LOCALIZATION; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; ISRAEL; JEWS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 13244298231     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20645     Document Type: Article

References (34)

1. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics, 2001. CA Cancer J Clin 2001;51:15-36.
2. http://www.health.gov.il/pages/
3. Israel Cancer Registry, Ministry of Health. Trends in cancer Incidence and mortality in Israel 1970-1995, Publication number 207, 1998.
4. Harms BA, Grochow L, Niederhuber JE, Ritter MA. Chapter 62: Colon and Rectum. In: Abeloff. Clinical oncology, 2nd ed. London: Churchill Livingstone, Inc., 2000, 1611-60.
5. Park DJ, Stoehlmacher J, Zhang W, Tsao-Wei DD, Groshen S, Lenz HJ. A Xeroderma pigmentosum group D gene polymorphism predicts clinical outcome to platinum-based chemotherapy in patients with advanced colorectal cancer. Cancer Res 2001;61:8654-8.
6. Jurinke C, van den Boom D, Cantor CR, Koster H. The use of MassARRAY technology for high throughput genotyping. Adv Biochem Eng Biotechnol 2002;77:57-74.
7. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, Rozen RA candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-3.
8. Storey A, Thomas M, Kalita A, Harwood C, Gardiol D, Mantovani F, Breuer J, Leigh IM, Matlashewski G, Banks L. Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature 1998;393:229-34.
9. Lazar V, Hazard F, Bertin F, Janin N, Bellet D, Bressac B. Simple sequence repeat polymorphism within the p53 gene. Oncogene 1993;8:1703-5.
10. Chen-Shtoyerman R, Theodor L, Harmati E, Friedman E, Dacka S, Kopelman Y, Sternberg A, Zarivach R, Bar-Meir S, Fireman Z. Genetic analysis of familial colorectal cancer in Israeli Arabs. Hum Mutat 2003;21:446-7.
11. Crow JF. The beanbag lives on. Nature 2001;409:771.
12. Figer A, Irmin L, Geva R, Flex D, Sulkes A, Friedman E. Genetic analysis of the APC gene regions involved in attenuated APC phenotype in Israeli patients with early onset and familial colorectal cancer. Br J Cancer 2001;85:523-6.
13. Heinimann K, Mullhaupt B, Weber W, Attenhofer M, Scott RJ, Fried M, Martinoli S, Muller H, Dobbie Z. Phenotypic differences in familial adenomatous polyposis based on APC gene mutation status. Gut 1998;43:675-9.
14. Wallis YL, Morton DG, McKeown CM, Macdonald F. Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition. J Med Genet 1999;36:14-20.
15. Joyce JA, Froggatt NJ, Davies R, Evans DG, Trembath R, Barton DE, Maher ER. Molecular genetic analysis of exons 1 to 6 of the APC gene in non-polyposis familial colorectal cancer. Clin Genet 1995;48:299-303.
16. Boardman LA, Schmidt S, Lindor NM, Burgart LJ, Cunningham JM, Price-Troska T, Snow K, Ahlquist DA, Thibodeau SN. A search for germline APC mutations in early onset colorectal cancer or familial colorectal cancer with normal DNA mismatch repair. Genes Chromosomes Cancer 2001;30:181-6.
17. Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH, Rozen R. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 1997;57:1098-102.
18. Slattery ML, Potter JD, Samowitz W, Schaffer D, Leppert M. Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 1999;8:513-8.
19. Chen J, Giovannucci E, Hankinson SE, Ma J, Willett WC, Spiegelman D, Kelsey KT, Hunter DJ. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. Carcinogenesis 1998;19:2129-32.
20. Dybdahl M, Vogel U, Frentz G, Wallin H, Nexo BA. Polymorphisms in the DNA repair gene XPD: correlations with risk and age at onset of basal cell carcinoma. Cancer Epidemiol Biomarkers Prev 1999;8:77-81.
21. Yu JJ, Mu C, Lee KB, Okamoto A, Reed EL, Bostick-Bruton F, Mitchell KC, Reed E. A nucleotide polymorphism in ERCC1 in human ovarian cancer cell lines and tumor tissues. Mutat Res 1997;382:13-20.
22. Vogel T, Guo NH, Guy R, Drezlich N, Krutzsch HC, Blake DA, Panet A, Roberts DD. Apolipoprotein E: a potent inhibitor of endothelial and tumor cell proliferation. J Cell Biochem 1994;54:299-308.
23. Williams RR, Sorlie PD, Feinleib M, McNamara PM, Kannel WB, Dawber TR. Cancer incidence by levels of cholesterol. JAMA 1981;245:247-52.
24. Mannes GA, Maier A, Thieme C, Wiebecke B, Paumgartner G. Relation between the frequency of colorectal adenoma and the serum cholesterol level. N Engl J Med 1986;315:1634-8.
25. Kervinen K, Sodervik H, Makela J, Lehtola J, Niemi M, Kairaluoma MI, Kesaniemi YA. Is the development of adenoma and carcinoma in proximal colon related to apolipoprotein E phenotype? Gastroenterology 1996;110:1785-90.
26. Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler KW, Vogelstein B. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 1990;247:49-56.
27. Fahy B, Bold RJ. Epidemiology and molecular genetics of colorectal cancer. Surg Oncol 1998;7:115-23.
28. Jen J, Kim H, Piantadosi S, Liu ZF, Levitt RC, Sistonen P, Kinzler KW, Vogelstein B, Hamilton SR. Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 1994;331:213-21.
29. Huang XE, Hamajima N, Katsuda N, Matsuo K, Hirose K, Mizutani M, Iwata H, Miura S, Xiang J, Tokudome S, Tajima K. Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polymorphisms with the risk of Japanese breast cancer. Breast Cancer 2003;10:307-11.
30. Hiraki A, Matsuo K, Hamajima N, Ito H, Hatooka S, Suyama M, Mitsudomi T, Tajima K. Different risk relations with smoking for non-small-cell lung cancer: comparison of TP53 and TP73 genotypes. Asian Pac J Cancer Prev 2003;4:107-12.
31. Hamajima N, Matsuo K, Suzuki T, Nakamura T, Matsuura A, Hatooka S, Shinoda M, Kodera Y, Yamamura Y, Hirai T, Kato T, Tajima K. No associations of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro polymorphisms with the risk of digestive tract cancers in Japanese. Cancer Lett 2002;181:81-5.
32. Sayhan N, Yazici H, Budak M, Bitisik O, Dalay N. P53 codon 72 genotypes in colon cancer. Association with human papillomavirus infection. Res Commun Mol Pathol Pharmacol 2001;109:25-34.
33. Wang YC, Chen CY, Chen SK, Chang YY, Lin P. p53 codon 72 polymorphism in Taiwanese lung cancer patients: association with lung cancer susceptibility and prognosis. Clin Cancer Res 1999;5:129-34.
34. Marchetti P, Cannita K, Ricevuto E, De Galitiis F, Di Rocco ZC, Tessitore A, Bisegna R, Porzio G, De Rubeis GP, Ventura T, Martinotti S, Ficorella C. Prognostic value of p53 molecular status in high-risk primary breast cancer. Ann Oncol 2003;14:704-8.