Colonic graft-versus-host disease

Current Opinion in Gastroenterology

Volumn 21, Issue 1, 2005, Pages 64-69

  Ross, William A ^a   Couriel, Daniel ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Colon; Graft versus host disease; Hematopoietic stem cell transplantation

Indexed keywords

BUDESONIDE; CYTOKINE; INFLIXIMAB; STEROID;

ABDOMINAL PAIN; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; APOPTOSIS; BLEEDING; DIARRHEA; ENDOSCOPIC BIOPSY; GASTROINTESTINAL TRACT; GRAFT VERSUS HOST REACTION; HUMAN; INCIDENCE; INTESTINE GRAFT; LIVER; PATHOGENESIS; REVIEW; RISK ASSESSMENT; SKIN; T LYMPHOCYTE; THROMBOCYTOPENIA; VOMITING;

COLONIC DISEASES; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; TRANSPLANTATION, HOMOLOGOUS;

EID: 13244295701     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (70)

1. Billingham RE: The biology of graft-versus-host reactions. Harvard Led 1966, 62:21-78.
2. Vogelsang GB, Lee L, Bensen-Kennedy DM: Pathogenesis and treatment of graft-versus-host disease after bone marrow transplant. Annu Rev Med 2003, 54:29-52. This is a through, recent review of GVHD.
3. Tabbara IA, Zimerman K, Morgan C, et al.: Allogenic hematopoietic stem cell transplantation. Arch Intern Med 2002, 162:1558-1566.
4. Gulbahce HE, Brown CA, Wick M, et al.: Graft-versus-host disease after solid organ transplant. Am J Clin Pathol 2003, 119:568-573. This is a report of the University of Minnesota solid organ transplantation program's experience with GVHD. The complication is particularly frequent after small bowel transplantation.
5. Mielcarek M, Martin PJ, Leisenring W, et al.: Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation. Blood 2003, 102:756-762. Onset of acute GVHD is delayed after nonmyeloablative HSCT, further undermining the traditional arbitrary 100-day cutoff
6. Atkinson K: Chronic graft-versus-host disease. Bone Marrow Transplant 1990, 5:69-82.
7. Hill GR, Ferrara JLM: The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogenic bone marrow transplantation. Blood 2000, 95:2754-2759.
8. Ratanatharathorn V, Ayash L, Lazarus HM, et al.: Chronic graft-versus-host disease: clinical manifestations and therapy. Bone Marrow Transplant 2001, 28:121-129.
9. Nikolic B, Lee S, Bronson RT, et al.: Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest 2000, 105:1289-1298.
10. Gratwohl A, Hermans J, Apperley J, et al.: Acute graft-versus-host disease: grade and outcome in patients with chronic myelogenous leukemia. Blood 1995, 86:813-818.
11. Champlin RE, Schmitz N, Horowitz MM, et al.: Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogenic transplantation. Blood 2000, 95:3702-3709.
12. Remberger M, Persson U, Hausenberger D, et al.: An association between human leukocyte antigen alleles and acute and chronic graft-versus-host disease after allogenic haemopoietic stem cell transplantation. Br J Haematol 2002, 119:751-759.
13. Nash RA, Pepe MS, Storb R, et al.: Acute graft-versus-host disease: analysis of risk factors after allogenic marrow transplantation and prophylaxis with cyclosporine and methotrexate. Blood 1992, 80:1838-1845.
14. Martin PJ, McDonald GB, Sanders JE, et al.: Increasingly frequent diagnosis of acute gastrointestinal graft-versus-host disease after allogenic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2004, 10:320-327. The increase most likely reflects the more liberal use of endoscopy.
15. Przepiorka D, Weisdorf D, Martin P, et al.: Consensus conference on acute GVHD grading. Bone Marrow Transplant 1995, 15:825-828.
16. Weisdorf DJ, Hurd D, Carter S, et al.: Prospective grading of graft-versus-host disease after unrelated donor marrow transplantation: a grading algorithm versus blind expert panel review. Biol Blood Marrow Transplant 2003, 9:512-518.
17. Margolis J, Borrello I, Finn IW: New approaches to treating malignancies with stem cell transplantation. Semin Oncol 2000, 27:524-530.
18. Goker H, Haznedaroglu IC, Chao NJ: Acute graft-versus-host disease: pathobiology and management. Exp Hematol 2001, 29:259-277.
19. Bombi JA, Nadal A, Carreras E, et al.: Assessment of histopathologic changes in the colonic biopsy in acute graft-versus-host disease. Am J Clin Pathol 1995, 103:690-695.
20. Shidham VB, Chang C-C, Shidham G, et al.: Colon biopsies for evaluation of acute graft-versus-host disease in allogenic bone marrow transplant patients. BMC Gastroenterol 2003, 3:5. This detailed review of GVHD histology in colon biopsies emphasizes intracyptal apoptosis.
21. Cox GJ, Matsui SM, Lo RS, et al.: Etiology and outcome of diarrhea after marrow transplantation: a prospective study, Gastroenterology 1994, 107:1398-1407.
22. Snover DC, Welsdorf SA, Vercellotti GM, et al.: A histopathologic study of gastric and small intestinal graft-versus-host disease following allogenic bone marrow transplantation. Hum Pathol 1985, 16:387-392.
23. Sviland L, Pearson ADJ, Eastham EJ, et al.: Histological features of skin and rectal biopsy specimens after autologous and allogenic bone marrow transplantation. J Clin Pathol 1988, 41:148-154.
24. Lee FD: Importance of apoptosis in the histopathology of drug related lesions in the large intestines. J Clin Pathol 1993, 46:118-122.
25. Snover DC: Mucosal damage simulating graft-versus-host disease in cytomegalovirus colitis. Transplantation 1985, 39:669-670.
26. Muller Cl, Zeiser R, Grullich C, et al.: Intestinal cryptosporidiosis mimicking acute graft-versus-host disease following matched unrelated hematopoietic stem cell transplantation. Transplantation 2004, 77:1478-1479.
27. Baron F, Gothot A, Salmon J-P, et al.: Clinical course and predictive factors for cyclosporin-induced autologous graft-versus-host disease after autologous hematopoietic stem cell transplantation. Br J Haematol 2000, 111:745-753.
28. Papadimitriou JC, Drachenberg LB, Beskow CO, et al.: Graft-versus-host disease-like features in mycophenolate mofetil-related colitis. Transplant Proc 2001, 33:2237-2238.
29. Berrebi D, Sautet A, Flejou J-F, et al.: Ticlopidine induced colitis: a histopathological study including apoptosis. J Clin Pathol 1998, 51:280-283.
30. Reinacher-Schick A, Seidensticker F, Petrasch S, et al.: Mesalazine changes apoptosis and proliferation in normal mucosa of patients with sporadic polyps of the large bowel. Endoscopy 2000, 32:245-254.
31. Lee EY, Clouse RE, Aliperti G, et al.: Small intestinal lesion resembling graft-versus-host disease. Arch Pathol Lab Med 1991, 115:529-532.
32. Sader C, Sharma S, Edwards MG: Graft-versus-host disease-type colitis: an unusual association of malignant thymoma. Ann Thorac Surg 2002, 73:1947-1948.
33. Schulenburg A, Turetschek K, Wrba F, et al.: Early and late gastrointestinal complications after myeloablative and non-myeloablative allogenic stem cell transplantation. Ann Hematol 2004, 83:101-106. This European study reports the evaluation of 42 patients with GI symptoms after HSCT.
34. Ponec RJ, Hackman RC, McDonald GB: Endoscopic and histologic diagnosis of intestinal graft-versus-host disease after marrow transplantation. Gastrointest Endosc 1999, 49:612-621.
35. Lipson SA, Perr HA, Koerper MA, et al.: Intramural duodenal hematoma after endoscopic biopsy in leukemic patients. Gastrointest Endosc 1996, 44:620-623.
36. Murakami CS, Chen GS, McDonald GB: Incidence and etiology of extrahepatic biliary obstruction in bone marrow transplant patients. Gastroenterology 1997, 112:A1340.
37. Terdiman JP, Linker CA, Ries CA, et al.: The role of endoscopic evaluation in patients with suspected intestinal graft-versus-host disease after allogenic bone marrow transplantation. Endoscopy 1996, 28:680-685.
38. Daneshpouy M, Socie G, Lemann M, et al.: Activated eosinophils in upper gastrointestinal tract of patients with graft-versus-host disease. Blood 2002, 99:3033-3040.
39. Roy J, Snover D, Weisdorf S, et al.: Simultaneous upper and lower endoscopic biopsy in the diagnosis of intestinal graft-versus-host disease. Transplantation 1991, 51:642-646.
40. Igbal N, Salzman D, Lazenby AJ, et al.: Diagnosis of gastrointestinal graft-versus-host disease. Am J Gastroenterol 2000, 95:3034-3038.
41. Wakui M, Okamoto S, Ishida A, et al.: Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. Bone Marrow Transplant 1999, 23:573-578.
42. Cruz-Correa M, Poonawala A, Abraham SC, et al.: Endoscopic findings predict the histologic diagnosis in gastrointestinal graft-versus-host disease. Endoscopy 2002, 34:808-813.
43. Fallows G, Rubinger M, Bernstein CN: Does gastroenterology consultation change management of patients receiving hematopoietic stem cell transplantation? Bone Marrow Transplant 2001, 28:289-294.
44. Bensinger WI, Martin PJ, Storer B, et al.: Transplantation of bone marrow as compared with peripheral blood cells from HLA-identical relatives in patients with hematologic cancers. N Engl J Med 2001, 344:175-181.
45. Kaur S, Cooper G, Fakult S, et al.: Incidence and outcome of overt gastrointestinal bleeding in patients undergoing bone marrow transplantation. Dig Dis Sci 1996, 41:598-603.
46. Schwartz JM, Wolford JL, Thornquist MD, et al.: Severe gastrointestinal bleeding after hemopoietic cell transplantation, 1987-97: incidence, causes, and outcome. Am J Gastroenterol 2001, 96:385-393.
47. Kaw M, Przepiorka D, Sekas G: Infectious complications of endoscopic procedures in bone marrow transplant recipients. Dig Dis Sci 1993, 38:71-74.
48. Bianco JA, Pepe MS, Higano C, et al.: Prevalence of clinically relevant bacteremia after upper gastrointestinal endoscopy in bone marrow transplant recipients. Am J Med 1990, 89:134-136.
49. Michalek J, Collins RH, Hill BJ, et al.: Identification and monitoring of graft-versus-host specific T-cell clone in stem cell transplantation. Lancet 2003, 361:1183-1185.
50. Kalantari BN, Mortele KJ, Cantisani V, et al.: CT features with pathologic correlation of acute gastrointestinal graft-versus-host disease after bone marrow transplantation in adults. AJR Am J Radiol 2003, 181:1621-1625. CT findings in a group of GVHD patients are described.
51. Klein SA, Martin H, Schreiber-Dietrich D, et al.: A new approach to evaluating intestinal acute graft-versus-host disease by transabdominal sonography and color Doppler imaging. Br J Haematol 2001, 115:929-934.
52. van Kraaij MGJ, Dekker AW, Verdonck LF, et al.: Infectious gastro-enteritis: an uncommon cause of diarrhea in adult allogenic and autologous stem cell recipients. Bone Marrow Transplant 2000, 26:299-303.
53. Akpek G, Valladares JL, Lee L, et al.: Pancreatic insufficiency in patients with chronic graft-versus-host disease. Bone Marrow Transplant 2001, 27:163-166.
54. Asplund S, Gramlich TL: Chronic mucosal changes in the colon in graft-versus-host disease. Mod Pathol 1998, 11:513-516.
55. Akpek G, Chinratanalab W, Lee LA, et al.: Gastrointestinal involvement in chronic graft-versus-host disease: a clinicopathologic study. Biol Blood Marrow Transplant 2003, 9:46-51. This is a report of 40 chronic GVHD patients with abdominal complaints that focuses on pathology.
56. Nevo S, Swam V, Enger C, et al.: Acute bleeding after bone marrow transplantation-incidence and effect on survival: a quantitative analysis in 1,402 patients. Blood 1998, 91:1469-1477.
57. Pihusch R, Salat C, Schmidt E, et al.: Hemostatic complications in bone marrow transplantation: a retrospective analysis of 447 patients. Transplantation 2002, 74:1303-1309.
58. Nevo S, Enger C, Borinsky ME, et al.: Acute bleeding and thrombocytopenia after bone marrow transplantation. Bone Marrow Transplant 2001, 27:65-72.
59. Nishida T, Hamaguchi M, Hirabayashi N, et al.: Intestinal thrombotic microangiopathy after allogenic bone marrow transplantation: a clinical imitator of acute enteric graft-versus-host disease. Bone Marrow Transplant 2004, 33:1143-1150. This is a reminder that not all abdominal symptoms in the acute post-HSCT period are secondary to GVHD.
60. Arora M, Burns LJ, Davies SM, et al.: Chronic graft-versus-host disease: a prospective cohort study. Biol Blood Marrow Transplant 2003, 9:38-45. A long-term follow-up on chronic GVHD is reported.
61. Lee SJ, Klein JP, Barrett AJ, et al.: Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse. Blood 2002, 100:406-414.
62. Socie G: Chronic graft-versus-host disease: clinical features and grading systems. Int J Hematol 2004, 79:216-220. This critical analysis of chronic GVHD grading systems finds no difference in utility.
63. Eagle DA, Gian V, Lauwers GY, et al.: Gastroparesis following bone marrow transplantation. Bone Marrow Transplant 2001, 28:59-62.
64. Weisdorf D, Haake R, Biazar B, et al.: Treatment of moderate/severe acute graft-versus-host disease after allogenic bone marrow transplantation: an analysis of clinical risk features and outcome. Blood 1990, 75:1024-1030.
65. McDonald GB, Bouvier M, Hockenberry DM, et al.: Oral beclomethasone dipropionate for treatment of intestinal graft-versus-host disease: a randomized, controlled trial. Gastroenterology 1998, 115:28-35.
66. Bertz H, Afting M, Kreisel W, et al.: Feasibility and response to budesonide as topical corticosteroids therapy for acute intestinal graft-versus-host disease. Bone Marrow Transplant 1999, 24:1185-1189.
67. Couriel D, Saliba R, Hicks K, et al.: Tumor necrosis factor-alpha blockade for the treatment of acute GVHD. Blood 2004, 104:649-654. This is a randomized study of the effectiveness of infliximab in steroid-refractory GVHD.
68. Lazarus HM, Vogelsang GB, Rowe JM: Prevention and treatment of acute graft-versus-host disease: the old and new-a report from the Eastern Cooperative Oncology Group (ECOG). Bone Marrow Transplant 1997, 19:577-600.
69. Ippoliti C, Champlin R, Bugazia N, et al.: Use of octreotide in the symptomatic management of diarrhea induced by graft-versus-host disease in patients with hematologic malignancies. J Clin Oncol 1997, 15:3350-3354.
70. Okada M, Okamoto T, Yamada S, et al.: Successful treatment of chronic graft-versus-host disease with sulfasalazine in allogenic bone marrow transplantation. Acta Haematol 1999, 102:107-109.