Beta-receptor blockade decreases elevated plasma levels of factor VIII: C in patients with deep vein thrombosis

Journal of Thrombosis and Haemostasis

Volumn 2, Issue 8, 2004, Pages 1316-1320

  Hoppener, M R ^a   Kraaijenhagen, R A ^a   Hutten, B A ^a   Buller H R ^a   Peters, R J G ^a   Levi, M ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Beta receptor blockade; Deep vein thrombosis; Elevated factor VIII; Propranolol; von Willebrand factor; VTE

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BLOOD CLOTTING FACTOR 8C; PROPRANOLOL; VASOPRESSIN; VON WILLEBRAND FACTOR;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ADULT; ARTICLE; ASIAN; CAUCASIAN; CLINICAL ARTICLE; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG WITHDRAWAL; EXERCISE; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECURRENT DISEASE; RISK FACTOR; THROMBOPHILIA; VENOUS THROMBOEMBOLISM; VOLUNTEER;

ADULT; COHORT STUDIES; FACTOR VIII; FEMALE; HUMANS; MALE; MIDDLE AGED; MODELS, STATISTICAL; PROPRANOLOL; RISK; RISK FACTORS; THROMBOEMBOLISM; THROMBOPHILIA; TIME FACTORS; VENOUS THROMBOSIS; VON WILLEBRAND FACTOR;

EID: 13244271969     PISSN: 15387933     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2004.00851.x     Document Type: Article

References (19)

1. Koster T, Blann AD, Briet E, Vandenbroucke JP, Rosendaal FR. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet 1995; 345: 152-5.
2. O'Donnell J, Tuddenham EG, Manning R, Kemball-Cook G, Johnson D, Laffan M. High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction. Thromb Haemost 1997; 77: 825-8.
3. Kraaijenhagen RA, in't Anker PS, Koopman MM, Reitsma PH, Prins MH, van den Ende A, Büller HR. High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism. Thromb Haemost 2000; 83: 5-9.
4. Kyrle PA, Minar E, Hirschl M, Bialonczyk C, Stain M, Schneider B, Weltermann A, Speiser W, Lechner K, Eichinger S. High plasma levels of factor VIII and the risk of recurrent venous thromboembolism. N Engl J Med 2000; 343: 457-62.
5. O'Donnell J, Mumford AD, Manning RA, Laffan M. Elevation of FVIII:C in venous thromboembolism is persistent and independent of the acute phase response. Thromb Haemost 2000; 83: 10-3.
6. Kamphuisen PW, Houwing-Duistermaat JJ, van Houwelingen HC, Eikenboom JC, Bertina RM, Rosendaal FR. Familial clustering of factor VIII and von Willebrand factor levels. Thromb Haemost 1998; 79 323-7.
7. Kamphuisen PW, Eikenboom JC, Rosendaal FR, Koster T, Blann AD, Vos HL, Bertina RM. High factor VIII antigen levels increase the risk of venous thrombosis but are not associated with polymorphisms in the von Willebrand factor and factor VIII gene. Br J Haematol 2001; 115 156-8.
8. Mansvelt EP, Laffan M, McVey JH, Tuddenham EG. Analysis of the F8 gene in individuals with high plasma factor VIIIC levels and associated venous thrombosis. Thromb Haemost 1998; 80: 561-5.
9. Kamphuisen PW, Eikenboom JC, Vos HL. High levels of factor VIII antigen are an important risk factor of deep-vein thrombosis. Blood 1997; 90: 1768-68.
10. Vosborgh CH, Richards AN. An experimental study of the sugar content and extra vascular coagulation of the blood after adrenalin injections. Am J Physiol 1903; ix: 35-51.
11. Ingram GI, Knights SF, Barrow EM, Dejanov II. The rise in factor-8 concentration after infusion of adrenaline. Br J Haematol 1968; 15: 326.
12. Ingram GI, Jones RV. The rise in clotting factor 8 induced in man by adrenaline. effect of alpha- and beta-blockers. J Physiol 1966; 187: 447-54.
13. Grant PJ. Hormonal regulation of the acute haemostatic response to stress. Blood Coag Fibrinol 1990; 1: 299-306.
14. Wall RT, Counts RB, Harker LA, Striker GE. Binding and release of factor VIII/von Willebrand's factor by human endothelial cells. Br J Haematol 1980; 46: 287-98.
15. Rosenberg JB, Haberichter SL, Jozwiak MA, Vokac EA, Kroner PA, Fahs SA, Kawai Y, Montgomery RR. The role of the D1 domain of the von Willebrand factor propeptide in multimerization of VWF. Blood 2002; 100: 1699-706.
16. Van Mourik JA, Broertjes R, Huisveld IA, Fijnvandraat K, Pajkrt D, van Genderen PJ, Fijnheer R. Von Willebrand factor propeptide in vacular disorders: a tool to distinguish between acute and chronic endothelial cell perturbation. Blood 1999; 94: 179-85.
17. Kraaijenhagen RA, Hoppener MR, Levi M, Büller HR. Beta-receptor blockade decreases elevated plasma levels of factor VIIIc in patients with deep vein thrombosis. The etiology of this important risk factor revealed? Blood 2000; 96: 450A-450A.
18. Schönauer V, Giannini S, Christ G, Quehenberger P, Bieglmayer C, Stain M, Kyrle PA, Weltermann A. The effect of beta-receptor blockade on factor VIII levels and thrombin generation in patients with venous thromboembolism. Thromb Haemost 2003; 89 837-41.
19. Fijnvandraat K, Peters M, ten Cate JW. Inter-individual variation in half-live of infused recombinant factor VIII is related to pre-infusion von Willebrand factor antigen levels. Br J Haematol 1995; 91: 1474-6.