Increased number of CD34+ cells in nasal mucosa of allergic rhinitis patients: Inhibition by a local corticosteroid

Clinical and Experimental Allergy

Volumn 35, Issue 1, 2005, Pages 34-38

  Sergejeva, S ^a   Malmhall C ^a   Lotvall J ^a   Pullerits, Teet ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Allergic rhinitis; CD34+ cells; Haematopoietic progenitor; Local corticosteroid

Indexed keywords

ALLERGEN; CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CORTICOSTEROID; FLUTICASONE PROPIONATE; PLACEBO;

ADULT; ALLERGIC RHINITIS; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DOUBLE BLIND PROCEDURE; EOSINOPHIL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NASAL BIOPSY; NOSE MUCOSA; POLLEN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEASON; SENSITIZATION;

ADOLESCENT; ADULT; ALLERGENS; ANDROSTADIENES; ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD34; CHEMOKINES, CXC; EOSINOPHILS; HUMANS; IMMUNOHISTOCHEMISTRY; NASAL MUCOSA; NASAL PROVOCATION TESTS; RECEPTORS, CXCR4; RHINITIS, ALLERGIC, SEASONAL; STATISTICS, NONPARAMETRIC; STEM CELLS; T-LYMPHOCYTES;

EID: 13244267057     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2004.02038.x     Document Type: Article

References (16)

1. Woolley MJ, Denburg JA, Ellis R, Dahlback M, O'Byrne PM. Allergen-induced changes in bone marrow progenitors and airway responsiveness in dogs and the effect of inhaled budesonide on these parameters. Am J Respir Cell Mol Biol 1994; 11:600-6.
2. Wood LJ, Inman MD, Denburg JA, O'Byrne PM. Allergen challenge increases cell traffic between bone marrow and lung. Am J Respir Cell Mol Biol 1998; 18:759-67.
3. Sehmi R, Howie K, Sutherland DR, Schragge W, O'Byrne PM, Denburg JA. Increased levels of CD34+ hemopoietic progenitor cells in atopic subjects. Am J Respir Cell Mol Biol 1996; 15:645-55.
4. Robinson DS, Damia R, Zeibecoglou K et al. CD34(+)/interleukin-5Ralpha messenger RNA+ cells in the bronchial mucosa in asthma: potential airway eosinophil progenitors. Am J Respir Cell Mol Biol 1999; 20:9-13.
5. Cameron L, Christodoulopoulos P, Lavigne F et al. Evidence for local eosinophil differentiation within allergic nasal mucosa: inhibition with soluble IL-5 receptor. J Immunol 2000; 164:1538-45.
6. Wood LJ, Sehmi R, Gauvreau GM et al. An inhaled corticosteroid, budesonide, reduces baseline but not allergen-induced increases in bone marrow inflammatory cell progenitors in asthmatic subjects. Am J Respir Crit Care Med 1999; 159:1457-63.
7. Gauvreau GM, Wood LJ, Sehmi R et al. The effects of inhaled budesonide on circulating eosinophil progenitors and their expression of cytokines after allergen challenge in subjects with atopic asthma. Am J Respir Crit Care Med 2000; 162:2139-44.
8. Kim YK, Uno M, Hamilos DL et al. Immunolocalization of CD34 in nasal polyposis. Effect of topical corticosteroids. Am J Respir Cell Mol Biol 1999; 20:388-97.
9. Wright DE, Bowman EP, Wagers AJ, Butcher EC, Weissman IL. Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med 2002; 195:1145-54.
10. Pullerits T, Praks L, Ristioja V, Lötvall J. Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and antihistamine in the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol 2002; 109:949-55.
11. Fina L, Molgaard HV, Robertson D et al. Expression of the CD34 gene in vascular endothelial cells. Blood 1990; 75:2417-26.
12. Aiuti A, Webb IJ, Bleul C, Springer T, Gutierrez-Ramos JC. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 1997; 185:111-20.
13. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 1998; 393:595-9.
14. Chelucci C, Casella I, Federico M et al. Lineage-specific expression of human immunodeficiency virus (HIV) receptor/coreceptors in differentiating hematopoietic precursors: correlation with susceptibility to T- and M-tropic HIV and chemokine-mediated HIV resistance. Blood 1999; 94:1590-600.
15. Nagase H, Kudo K, Izumi S et al. Chemokine receptor expression profile of eosinophils at inflamed tissue sites: decreased CCR3 and increased CXCR4 expression by lung eosinophils. J Allergy Clin Immunol 2001; 108:563-9.
16. Eddleston J, Christiansen SC, Zuraw BL. Functional expression of the C-X-C chemokine receptor CXCR4 by human bronchial epithelial cells: regulation by proinflammatory mediators. J Immunol 2002; 169:6445-51.