Randomized, double-blind, placebo-controlled pilot study to assess the value of free radical scavengers in reducing inflammation induced by cryotherapy

Clinical and Experimental Dermatology

Volumn 30, Issue 1, 2005, Pages 14-16

  Gach, J E ^a   Humphreys, F ^b   Berth Jones, J ^a  

^a WALSGRAVE HOSPITAL   (United Kingdom)

^b WARWICK HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CORTICOSTEROID; LIQUID NITROGEN; PLACEBO; SCAVENGER;

ADULT; ARTICLE; BLISTER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYOTHERAPY; DOUBLE BLIND PROCEDURE; EDEMA; ERYTHEMA; HUMAN; INFLAMMATION; PAIN ASSESSMENT; PARALLEL DESIGN; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SYMPTOMATOLOGY; VERRUCA VULGARIS;

ADOLESCENT; ADULT; AGED; ASCORBIC ACID; BLISTER; CRYOTHERAPY; DERMATITIS; DOUBLE-BLIND METHOD; EDEMA; ERYTHEMA; FEMALE; HUMANS; MALE; MIDDLE AGED; PAIN, POSTOPERATIVE; PILOT PROJECTS; VITAMIN E; WARTS;

EID: 13244264776     PISSN: 03076938     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2230.2004.01694.x     Document Type: Article

References (7)

1. Hindson TC, Spiro J, Scott LV. Clobetasol propionate ointment reduces inflammation after cryotherapy. Br J Dermatol 1985; 112: 599-602.
2. Humphreys F, Spiro J. The effects of topical indomethacin and clobetasol propionate on post-cryotherapy inflammation. Br J Dermatol 1995; 132: 762-5.
3. Colver BG, Dawber RPR. Cryosurgery-the principles and simple practice. Clin Exp Dermatol 1989; 14: 1-6.
4. Eberlein-König B, Placzek M, Przybilla B. Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and D-α-tocopherol (vitamin E). J Am Acad Dermatol 1998; 38: 45-8.
5. Dreher F, Gabard B, Schwindt DA, Maibach HI. Topical melatonin in combination with vitamins E and C protects from ultraviolet-induced erythema: a human study in vivo. Br J Dermatol 1998; 139: 332-9.
6. Packer JE, Slater TF, Willson RL. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature 1979; 278: 737-8.
7. Ritter EF, Axelrod M, Minn KW et al. Modulation of ultraviolet light-induced epidermal damage: beneficial effects of tocopherol. Plast Reconstr Surg 1997; 100: 973-80.