Use and comparison of different internal ribosomal entry sites (IRES) in tricistronic retroviral vectors

BMC Biotechnology

Volumn 4, Issue , 2004, Pages

  Douin, Victorine ^a   Bornes, Stephanie ^a   Creancier, Laurent ^b   Rochaix, Philippe ^a   Favre, Gilles ^a   Prats, Anne Catherine ^b   Couderc, Bettina ^a  

^a INSTITUT CLAUDIUS REGAUD   (France)

^b CHU RANGUEIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIOMARKERS; DNA; MEDICAL IMAGING; VIRUSES;

GENE THERAPY PROTOCOLS; HUMAN CELLS; INTERNAL RIBOSOMAL ENTRY SITES (IRES); POYCISTRONIC RETROVIRAL VECTORS;

GENETIC ENGINEERING;

B7 ANTIGEN; CD70 ANTIGEN; COMPLEMENTARY DNA; FIBROBLAST GROWTH FACTOR 2; MESSENGER RNA; MYC PROTEIN; RETROVIRUS VECTOR; ANTIBIOTIC G 418; BLEOMYCIN; CD70 PROTEIN, HUMAN; GENTAMICIN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; PHLEOMYCIN; TNFSF7 PROTEIN, MOUSE; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CELL SPECIFICITY; CELL TYPE; CISTRON; CONTROLLED STUDY; GENE CONSTRUCT; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOHISTOCHEMISTRY; INTERNAL RIBOSOME ENTRY SITE; MELANOMA; NONHUMAN; ONCOGENE C MYC; TUMOR CELL; TUMOR IMMUNITY; ADENOCARCINOMA; ANIMAL; BIOSYNTHESIS; CELL STRAIN 3T3; CHEMISTRY; COMPARATIVE STUDY; DRUG RESISTANCE; EXPERIMENTAL MELANOMA; EXPERIMENTAL NEOPLASM; GENE EXPRESSION REGULATION; GENE TRANSFER; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; KIDNEY; METABOLISM; METHODOLOGY; MOUSE; PATHOLOGY; PRENATAL DEVELOPMENT; RETROVIRUS; RIBOSOME; SKIN TUMOR; TRANSGENE; TUMOR CELL LINE; VIROLOGY; VIRUS GENE;

ENCEPHALOMYOCARDITIS VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1; MURINAE;

ADENOCARCINOMA; ANIMALS; ANTIGENS, CD; ANTIGENS, CD70; ANTIGENS, CD80; BLEOMYCIN; CELL LINE, TUMOR; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENES, VIRAL; GENETIC VECTORS; GENTAMICINS; HUMANS; KIDNEY; MAMMARY NEOPLASMS, ANIMAL; MELANOMA; MELANOMA, EXPERIMENTAL; MEMBRANE PROTEINS; MICE; NIH 3T3 CELLS; RETROVIRIDAE; RIBOSOMES; RNA, MESSENGER; SKIN NEOPLASMS; TRANSDUCTION, GENETIC; TRANSGENES; VIRAL STRUCTURAL PROTEINS;

EID: 13244262697     PISSN: 14726750     EISSN: None     Source Type: Journal    
DOI: 10.1186/1472-6750-4-16     Document Type: Article

References (37)

1. Attal J, Theron MC, Houdebine LM: The optimal use of IRES (internal ribosome entry site) in expression vectors. Genet Anal 1999, 15:161-165.
2. de Felipe P: Polycistronic viral vectors. Curr Gene Ther 2002, 2:355-378.
3. De Felipe P, Izquierdo M: Tricistronic and tetracistronic retroviral vectors for gene transfer. Hum Gene Ther 2000, 11: 921-1931.
4. de Felipe P, Izquierdo M: Construction and characterization of pentacistronic retrovirus vectors. J Gen Virol 2003, 84:1281-1285.
5. Martinez-Salas E: Internal ribosome entry site biology and its use in expression vectors. Curr Opin Biotechnol 1999, 10: 58-464.
6. Pelletier J, Sonenberg N: Internal binding of eucaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts. J Virol 1989, 63:441-444.
7. Douin-Echinard V, Bornes S, Rochaix P, Tilkin AF, Peron JM, Bonnet J, Favre G, Couderc B: The expression of CD70 and CD80 by gene-modified tumor cells induces an antitumor response depending on the MHC status. Cancer Gene Ther 2000, 7:1543-1556.
8. Jang SK, Krausslich HG, Nicklin MJ, Duke GM, Palmenberg AC, Wimmer E: A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J Virol 1988, 62:2636-2643.
9. Borman AM, Bailly JL, Girard M, Kean KM: Picornavirus internal ribosome entry segments: comparison of translation efficiency and the requirements for optimal internal initiation of translation in vitro. Nucleic Acids Res 1995, 23:3656-3663.
10. Fan L, Owen JS, Dickson G: Construction and characterization of polycistronic retrovirus vectors for sustained and high-level co-expression of apolipoprotein A-I and lecithin-cholesterol acyltransferase. Atherosclerosis 1999, 147:139-145.
11. Fussenegger M, Mazur X, Bailey JE: pTRIDENT, a novel vector family for tricistronic gene expression in mammalian cells. Biotechnol Bioeng 1998, 57:1-10.
12. Borman AM, Le Mercier P, Girard M, Kean KM: Comparison of picornaviral IRES-driven internal initiation of translation in cultured cells of different origins. Nucleic Acids Res 1997, 25: 25-932.
13. De Pietri Tonelli D, Mihailovich M, Schnurbus R, Pesole G, Grohovaz F, Zacchetti D: Translational control of Scamper expression via a cell-specific internal ribosome entry site. Nucleic Acids Res 2003, 31:2508-2513.
14. Kozak M: New ways of initiating translation in eukaryotes? Mol Cell Biol 2001, 21:1899-1907.
15. Bonnal S, Boutonnet C, Prado-Lourenco L, Vagner S: IRESdb: the Internal Ribosome Entry Site database. Nucleic Acids Res 2003, 31:427-428.
16. Bonnal S, Schaeffer C, Creancier L, Clamens S, Moine H, Prats AC, Vagner S: A single internal ribosome entry site containing a G quartet RNA structure drives fibroblast growth factor 2 gene expression at four alternative translation initiation codons. J Biol Chem 2003, 278:39330-39336.
17. Creancier L, Morello D, Mercier P, Prats AC: Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent tissue-specific regulation. J Cell Biol 2000, 150:275-281.
18. Creancier L, Mercier P, Prats AC, Morello D: c-myc Internal ribosome entry site activity is developmentally controlled and subjected to a strong translational repression in adult transgenic mice. Mol Cell Biol 2001, 21:1833-1840.
19. Nanbru C, Lafon I, Audigier S, Gensac MC, Vagner S, Huez G, Prats AC: Alternative translation of the proto-oncogene c-myc by an internal ribosome entry site. J Biol Chem 1997, 272: 2061-32066.
20. Vagner S, Waysbort A, Marenda M, Gensac MC, Amalric F, Prats AC: Alternative translation initiation of the Moloney murine leukemia virus mRNA controlled by internal ribosome entry involving the p57/PTB splicing factor. J Biol Chem 1995, 270:20376-20383.
21. Vagner S, Touriol C, Galy B, Audigier S, Gensac MC, Amalric F, Bayard F, Prats H, Prats AC: Translation of CUG- but not AUG-initiated forms of human fibroblast growth factor 2 is activated in transformed and stressed cells. J Cell Biol 1996, 135: 391-1402.
22. Vagner S, Galy B, Pyronnet S: Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites. EMBO Rep 2001, 2:893-898.
23. Brasey A, Lopez-Lastra M, Ohlmann T, Beerens N, Berkhout B, Darlix JL, Sonenberg N: The leader of human immunodeficiency virus type 1 genomic RNA harbors an internal ribosome entry segment that is active during the G2/M phase of the cell cycle. J Virol 2003, 77:3939-3949.
24. Douin-Echinard V, Robbins PD, Lotze MT, Favre G, Couderc B: Enhancement of anti-tumor immunity by injection of fibroblasts genetically engineered to produce IL-12 and to express CD70. Adv Exp Med Biol 1998, 451:353-357.
25. Douin-Echinard V, Peron JM, Lauwers-Cances V, Favre G, Couderc B: Involvement of CD70 and CD80 intracytoplasmic domains in the co-stimulatory signal required to provide an antitumor immune response. Int Immunol 2003, 15:359-372.
26. Townsend SE, Allison JP: Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science 1993, 259:368-370.
27. Couderc B, Zitvogel L, Douin-Echinard V, Djennane L, Tahara H, Favre G, Lotze MT, Robbins PD: Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells. Cancer Gene Ther 1998, 5: 63-175.
28. Murakami M, Watanabe H, Niikura Y, Kameda T, Saitoh K, Yamamoto M, Yokouchi Y, Kuroiwa A, Mizumoto K, Iba H: High-level expression of exogenous genes by replication-competent retrovirus vectors with an internal ribosomal entry site. Gene 1997, 202: 3-29.
29. Martinez-Salas E, Ramos R, Lafuente E, Lopez de Quinto S: Functional interactions in internal translation initiation directed by viral and cellular IRES elements. J Gen Virol 2001, 82: 73-984.
30. West MJ, Sullivan NF, Willis AE: Translational upregulation of the c-myc oncogene in Bloom's syndrome cell lines. Oncogene 1995, 11:2515-2524.
31. Hellen CU, Witherell GW, Schmid M, Shin SH, Pestova TV, Gil A, Wimmer E: A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein. Proc Natl Acad Sci U S A 1993, 90:7642-7646.
32. Hellen CU, Sarnow P: Internal ribosome entry sites in eukaryotic mRNA molecules. Genes Dev 2001, 15:1593-1612.
33. Belsham GJ: Dual initiation sites of protein synthesis on foot-and-mouth disease virus RNA are selected following internal entry and scanning of ribosomes in vivo. Embo J 1992, 11: 105-1110.
34. Roberts LO, Seamons RA, Belsham GJ: Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins. Rna 1998, 4:520-529.
35. Anthony DD, Merrick WC: Eukaryotic initiation factor (eIF)-4F. Implications for a role in internal initiation of translation. J Biol Chem 1991, 266:10218-10226.
36. Mouriaux F, Martinot V, Pellerin P, Patenotre P, Rouland JF, Constantinides G: Survival after malignant tumors of the orbit and periorbit treated by exenteration. Acta Ophthalmol Scand 1999, 77:326-330.
37. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987, 162:156-159.